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| 1 | 未处理或上游法处理后精子的DNA碎片能否预测使用赠卵ICSI后的妊娠?显示文摘本研究比较了未处理的精子和上游法处理后精子中的DNA碎片值(SDF)预测使用赠卵ICSI后妊娠的可能性。总共81例不孕女性接受通过夫精和赠卵ICSI后的胚胎移植。这种方式排除了目前公认的影响精子DNA修复的女方因素。在ICSI受精时,同时使用DNA碎片率检测试剂盒(Halosperm)进行盲法检测未处理的和上游法处理后精液中的精子DNA碎片。经上游法处理后的精液样本中SDF值呈显著下降。有趣的是,未处理的或上游法处理后精液样本中的SDF值均能预测妊娠。通过ROC曲线和其衍生的约登指数计算得出未处理前和上游法处理后精子sDF的临界值分别是24.8%和17.5%。未处理精子SDF预测妊娠的敏感性和特异性分别为75%和69%,而上游法处理后的精子SDF预测妊娠的敏感性和特异性分别是78%和73%。虽然SDF值增高与生育呈负相关,但我们发现在精子筛选降低sDF值后再与赠卵进行ICSI并不能保证获得妊娠。这表明目前的技术手段对于一些DNA损伤仍无法探及,从而相对影响辅助生殖成功的机率。因此,我们认为对目前的“冰山模式”作一些修饰后可以用来解释SDF在生育中的作用。 | Jaime Gosálvez Pedro Caballero Carmen López-Fernández Leonor Ortega José Andrés Guijarro José Luís FernAndez Stephen D Johnston Rocio Nufiez-Calonge | 2013 | Asian Journal of Andrology2013，15，6： | 3 |
| 2 | 在经历 transcatheter 的病人的 atrial 纤维性颤动的临床、预示的含意大动脉的阀门培植显示文摘 AIM: To study a cohort of consecutive patients under-going transcatheter aortic valve implantation (TAVI) and compare the outcomes of atrial fibrillation (AF) patients vs patients in sinus rhythm (SR). METHODS: All consecutive patients undergoing TAVI in our hospital were included. The AF group comprised patients in AF at the time of TAVI or with history of AF, and were compared with the SR group. Procedural, echocardiographic and follow-up variables were compared. Likewise, the CHA 2 DS 2-VASC stroke risk score and HAS-BLED bleeding risk score and antithrombotic treatment at discharge in AF patients were compared with that in SR patients. RESULTS: From a total of 34 patients undergoing TAVI, 17 (50%) were allocated to the AF group, of whom 15 (88%) were under chronic oral anticoagulation. Patients in the AF group were similar to those in the SR group except for a trend (P = 0.07) for a higher logistic EuroSCORE (28% vs 19%), and a higher prevalence of hypertension (82% vs 53%) and chronic renal failure (17% vs 0%). Risk of both stroke and bleeding was high in the AF group (mean CHA 2 DS 2-VASC 4.3, mean HAS-BLED 2.9). In the AF group, treatment at discharge included chronic oral anticoagulation in all except one case, and in association with an antiplatelet drug in 57% of patients. During a mean follow-up of 11 mo (maximum 32), there were only two strokes, none of them during the peri-procedural period: one in the AF group at 30 mo and one in the SR group at 3 mo. There were no statistical differences in procedural success, and clinical outcome (survival at 1 year 81% vs 74% in AF and SR groups, respectively, P = NS). CONCLUSION: Patients in AF undergoing TAVI show a trend to a higher surgical risk. However, in our cohort, patients in AF did not have a higher stroke rate compared to the SR group, and the prognosis was similar in both groups. | Pablo Salinas Raúl Moreno Luis Calvo Santiago Jiménez-Valero Guillermo Galeote Angel Sánchez-Recalde Teresa López-Fernández Sergio Garcia-Blas Diego Iglesias Luis Riera Isidro Moreno-Gómez Jose María Mesa Ignacio Plaza Rocio Ayala Rosa Gonzalez José-Luis López-Sendón | 2012 | World Journal of Cardiology2012，4，1： | 2 |
| 3 | Cost-sensitive learning based on Bregman divergences 显示文摘 | RAUL S R ROCIO A R ALICIA G C | 2009 | Machine Learning Journal2009，76，： | 1 |
| 4 | Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from coloreetal cancer patients 显示文摘 | Mariaa A N S Rocio G V Tamara M S | 2014 | Mol Nutr Food Res2014，58，： | 1 |
| 5 | Association analysis of MICA gene polymorphism and MICA-129 dimorphism with inflammatory bowel disease susceptibility in a Spanish population显示文摘 | Ruth López-Hernández Mariano Valdés Daniel Lucas Jose Antonio Campillo Pedro Martínez-Garcia Hortensia Salama Manuela López Gema Salgado Carmen Botella Alfredo Minguela Manuel Miras Maria Rocio álvarez-López Fernando Carballo Manuel Muro | 2010 | Human Immunology2010，，5： | 1 |
| 6 | Marine microalgae culture:Chaetoceros grucilis with Zeolitic Product ZJBTEC-56 and a commercial fertilizer as a Nutrient显示文摘 | Jose L L Rocio G G Maria S | 1995 | Aquacttl urol Engitwering1995，14，4： | 1 |
| 7 | Incidence of childhood cancer among Mexican children registered under a public medical insurance program显示文摘 | Roberto Rivera‐Luna Cecilia Correa‐González Eduardo Altamirano‐Alvarez Fernando Sánchez‐Zubieta Rocio Cárdenas‐Cardós Gabriela Escamilla‐Asian Alberto Olaya‐Vargas Aurora Bautista‐Marquez Manuel Aguilar‐Romo | 2012 | Int. J. Cancer2012，，： | 1 |
| 8 | Blastoschizomyces capitatus infection in patients with leukemia: report of 26 cases 显示文摘 | Rodrigo M Miguel S Rocio P | 2004 | Clin Infect Dis2004，38，3： | 1 |
| 9 | Non-pungent capsicinods from sweet pepper synthesis and evaluation of the chemopreventive and anticancer potential显示文摘 | ANTONIO M CONCEPCION L ROCIO S | 2003 | European Journal of Nutrition2003，42，1： | 1 |
| 10 | Limited overlapping roles of P15INK4b and P18INK4c cell cycle inhibitors in proliferation and tumorigenesis显示文摘 | Esther L Marcos M Rocio S | 2000 | The EMBO Journal2000，19，： | 1 |
| 11 | Stochastic joint optimization of wind generation and pumped-storage units in an electricity market显示文摘 | Javier G G Rocio M R M Luz M S | 2008 | IEEE Trans on Power Systems2008，23，2： | 1 |
| 12 | Heterogeneous users and willingness to pay in an ongoing payment for watershed protection initiative in the C olombian Andes 显示文摘 | Rocio M Jorge M Wunder S | 2012 | Ecological Economic s2012，，75： | 1 |
| 13 | The Arabidopsis thaliana ABC protein superfamily,a complete inventory显示文摘 | Rocio Sánchez-Fernández Emyr Davies T G Julian O D | | 0，，276： | 1 |
| 14 | Chronic administration of genistein improves endothelial dysfunction in spontaneously hyper- tensive rats: involvement of eNOS, caveolin and calmodulin ex- pression and NADPH oxidase activity显示文摘 | Rocio V Manuel S Milagros G | 2007 | Clin Sci2007，112，3： | 1 |
| 15 | The Arabidopsis thaliana ABC protein superfamily, a complete inventory 显示文摘 | SánchezFernández Rocio Davies T G Coleman Julian O | 2001 | Journal of Bioliogical Chemistry2001，32，30： | 1 |
| 16 | Stochastic joint optimization of wind generation and pumped-storage units in an electricity market 显示文摘 | Javier G G Rocio M R M Luz M S | 2008 | IEEE Trans on Power Systems2008，23，2： | 1 |
| 17 | Using eigenstructure decomposi- tions of time-varying autoregressions in common spatialpattern-based EEG signal classification 显示文摘 | DAVID G ROCIO S V | 2012 | Biomedical Signal Processing and Control2012，7，6： | 1 |
| 18 | Mechanisms of resistance to endocrine therapy in breast cancer:Focus on signaling pathways,miRNAs and genetically based resistance显示文摘 | Rocio GB Nancy S Lorenza D | 2012 | Int J Mol Sci2012，14，1： | 1 |
| 19 | 雷依多电影院改建显示文摘我们的设计在大规模的改扩建雷依多电影院建筑竞赛中脱影而出,为了扩大舞台面积,我们移走了第一排的观众席,进而拆除了剧场内的楼梯,将其外置。从前楼梯的位置增加为观众席。楼梯的外置在原有建筑结构与新设计之间的张力。我们将这种张力继续,在保留原有建筑结构的基础上,星状的建筑平面构造了完整而曲折的建筑新立面,给来访者以期待和神秘感。 | Luis Pe■a Rocio Pe■a Mario S■ngalli | 2007 | 安家2007，0，11： | 0 |
| 20 | Magazzino意大利艺廊显示文摘Magazzino意大利艺廊位于纽约,是由展品主人Nancy Olnick和Giorgio Spanu构思出的一个私人项目,旨在收藏他们的战后意大利艺术品。设计团队受业主委托,要对已有的11000平方英尺的建筑进行全面翻修,并增建一个14000平方英尺的新建筑。现有的L形建筑结构于1946年建成,当时是奶制品的分销中心,并被装货码头和檐蓬包围。新的建筑需要一个更高的空间,用于收藏一些大件的艺术品,并易于引入自然光线。 | Miguel Quismondo Jesús Aparicio Alfaro Rocio Calzado López Miguel Bello Escribano Javier Callejas 范嘉苑 | 2018 | 现代装饰2018，0，7： | 0 |
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