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| 1 | Disagreement between symptom-reflux association analysis parameters in pediatric gastroesophageal reflux disease investigation显示文摘AIM: To assess the agreement within 3 commonly used symptom-reflux association analysis (SAA) parameters investigating gastroesophageal reflux disease (GERD) in infants. METHODS: Twenty three infants with suspected GERD were included in this study. Symptom index (SI), Symptom sensitivity index (SSI) and symptom association probability (SAP) related to cough and irritability were calculated after 24 h combined pH/multiple intraluminal impedance (MII) monitoring. Through defined cutoff values, SI, SSI and SAP values are differentiated in normal and abnormal, whereas abnormal values point towards gastroesophageal reflux (GER) as the origin of symptoms. We analyzed the correlation and the concordance of the diagnostic classification of these 3 SAA parameters.RESULTS: Evaluating the GER-irritability association, SI, SSI and SAP showed non-identical classification of normal and abnormal cases in 39.2% of the infants. When irritability was taken as a symptom, there was only a poor inter-parameter association between SI and SSI, and between SI and SAP (Kendall’s tau b = 0.37, P < 0.05; Kendall’s tau b = 0.36, P < 0.05, respectively). Evaluating the GER-cough association, SI, SSI and SAP showed non-identical classification of normal and abnormal cases in 52.2% of the patients. When cough was taken as a symptom, only SI and SSI showed a poor inter-parameter association (Kendall’s tau b = 0.33, P < 0.05). CONCLUSION: In infants investigated for suspected GERD with pH/MII-monitoring, SI, SSI and SAP showed a poor inter-parameter association and important dis-agreements in diagnostic classification. These limitations must be taken into consideration when interpreting the results of SAA in infants. | Samuel C Lüthold Mascha K Rochat Peter Bhler | 2010 | World Journal of Gastroenterology2010，16，19： | 3 |
| 2 | Effect of RasGAP N2 gragment-derived peptide on tumor growth in mice 显示文摘 | Michod D Annibaldi A Schaefer S Dapples C Rochat B Widmann C | 2009 | J Natl Cancer Inst2009，101，11： | 1 |
| 3 | Morphogenesis and renewal of hair follicles from adult multipotent stem cells显示文摘 | Oshima H Rochat A Kadzia C | 2001 | Cell2001，104，： | 1 |
| 4 | Morphogenesis and renewal of hair follicles from adult muhipotent stem cells显示文摘 | Oshima H Rochat A Kedzia C | 2001 | Cell2001，104，2： | 1 |
| 5 | Morphogenesis and renewal of hair follicles from adult multipotent stem cells 显示文摘 | OSHIMA H ROCHAT A KEDZIA C | 2001 | Cell2001，104，2： | 1 |
| 6 | Characterization of a tissue-specific and developmentally regulated beta-1,3 -glucanase gene in pea (Pisum sativum)显示文摘 | Buchner P Rochat C Wuilleme S | 2002 | Plant Mol Biol2002，49，： | 1 |
| 7 | Morphogenesis and renewal of hair follicles from adult multipotent stem cells显示文摘 | Oshima H Rochat A Kedzia C | 2001 | Cell2001，104，2： | 1 |
| 8 | Morphogenesis and renewal of hair follicle from adult multipotene stem cells 显示文摘 | Oshima H Rochat A Kedzia C | 2001 | Cell2001，104，2： | 1 |
| 9 | Morphogenesis and renewal of hair follicles from adult multipotent stem cells 显示文摘 | OSHIMA H ROCHAT A KEDZIA C | 2001 | Cell2001，，2： | 1 |
| 10 | Morphogenesis and renewal of hair follicle from adult multipotent stem cells显示文摘 | Oshima H Rochat A Kedzia C | 2001 | Cell2001，104，2： | 1 |
| 11 | Stem cell niches in mammals显示文摘 | Mitsiadis T A Barrandon O Rochat A Barrandon Y De Bari C | 2007 | Exp Cell Res2007，313，： | 1 |
| 12 | Morphogenesis and renewal of hair follicles from adult multipotent stem cells 显示文摘 | Oshima H Rochat A Kedzia C | 2001 | Cell2001，104，： | 1 |
| 13 | Morphogenesis and renewal of hair follicles from adult multipotent stem cells 显示文摘 | Oshima H Rochat A Kedzia C | 2001 | Cell2001，104，2： | 1 |
| 14 | Morphogenesis and renewal of hair follicles from adult multi-potent stem cells显示文摘 | Oshima H Rochat A Kedzia C | 2001 | Cell2001，104，： | 1 |
| 15 | Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome 显示文摘 | Chavanas S Bodemer C Rochat A | 2000 | Nat Genet2000，25，2： | 1 |
| 16 | Storage reserve accumulation in Arabidop- sis 显示文摘 | Baud S Dubreucq B Miquel M Rochat C Lepi- niec L | 2008 | Plant Cell2008，34，5： | 1 |
| 17 | Morphogenesis and renewal of hair follicle from adult multipotene stem cells显示文摘 | OSHIMA H ROCHAT A KEDZIA C | 2001 | Cell2001，104，2： | 1 |
| 18 | Structure and expression profile of the sucrose synthase multigene family in Arabidopsis 显示文摘 | BAUD S VAULTIER M N ROCHAT C | 2004 | Journal of Experimental Botany2004，396，： | 1 |
| 19 | Morphogenesis and renewal of hair follicles from adult multipotent stem cells 显示文摘 | OSHIMA H ROCHAT A KEDZIAET C | 2001 | Cell2001，104，2： | 1 |
| 20 | Morphogenesis and renewal of hair follicle from adult multipotene stem cells 显示文摘 | Oshima H Rochat A Kedzia C | 2001 | Cell2001，104，2： | 1 |
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