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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Pro- moters in Heterogeneous Catalysis : The Role of CI on Ethy- lene Epoxidation overAg 显示文摘 | Rocha T C R Haevecker M Knop-Gericke A | 2014 | J Catal2014，312，： | 1 |
| 3 | Molecular differenc- es between hydrocarbon and fluorocarbon surfaetants at the COJ water interface 显示文摘 | Stone M T Da Rocha S R P Rossky P J | 2003 | Journal of Physics Chemistry2003，107，10： | 1 |
| 4 | Anticancer, antichemotactic and antimicrobial activities of marine sponges collected off the coast of Santa Catarina, southern Brazil显示文摘 | Noel R Monks Clea Lerner Amélia T Henriques Fabiane M Farias Elfrides E.S Schapoval Edna S Suyenaga Adriana B da Rocha Gilberto Schwartsmann Beatriz Mothes | 2002 | Journal of Experimental Marine Biology and Ecology2002，，1： | 1 |
| 5 | Microstructural Evolution at the Initial Stages of Continuous Annealing of Cold Rolled Dual phase Steels 显示文摘 | Rocha R O Melo T M F Pereloma E V | 2005 | Materials Science and Engineering2005，391，12： | 1 |
| 6 | Hyperosmotic NaCl and severe hemorrhagic shock显示文摘 | VELASCO I T PONTIERI V ROCHAE SILVA M JR | 1980 | Am J Phsiol1980，239，5： | 1 |
| 7 | Microstructural evolution at the initial stages of continuous annealing of cold rolled dual-phase steel显示文摘 | Rocha R O Melo T M F Pereloma E V Santos D B | 2005 | Materials Science and Engineering A2005，391，： | 1 |
| 8 | Microstructure evolution at the initial stages of continuous annealing of cold rolled dual-phase steel显示文摘 | ROCHA R O MELO T M F PERELOMA E V | 2005 | Materials Science and Engineering A2005，391，12： | 1 |
| 9 | Microstructural evolution at the initial stages of continuous annealing of cold rolled dual-phase steel 显示文摘 | Rocha R O Melo T M F Pereloma E V Santos D B | 2005 | Materials Science and Engineering2005，391，： | 1 |
| 10 | Determination of sulfur dioxide in wine using a quartz crystal microbalance显示文摘 | Comes M T Rocha T A Duarte A C | | 0，，09： | 1 |
| 11 | Steviol effect, a glycoside of Stevia rebaudiana, on glucose clearances in rats 显示文摘 | Mehs M S Rocha S T Augusto A | 2009 | Brazilian Journal of Biology2009，69，2： | 1 |
| 12 | A proposal for teaching undergraduate chemistry students carbohydrate biochemistry by problem-based learning activities显示文摘 | Figueira A C M Rocha J B T | 2014 | Biochem Mol Biol Educ2014，42，1： | 1 |
| 13 | Biologicalactivities of sulfated polysaccharides from tropical seaweeds显示文摘 | Costa L S Fidelis G P Cordeiro S L R M Oliveira D A Sabry R B G CSmara L T D B Nobre MSS PCosta J Almeida-Lima E H C Farias E L Leite H A 0 Rocha | 2010 | Biomedicine & Pharmacotherapy2010，64，1： | 1 |
| 14 | Studies on the stripping voltammetric determination and speciation of chromium at a rotating-disc bismuth fiLm electrode显示文摘 | JORGE E O ROCHA M M FONSECA I T E | 2010 | Talanta2010，81，12： | 1 |
| 15 | Automatic control of the NMB level in general anaesthesia with a switching total system mass control strategy显示文摘 | Teixeira M Mendonca T Rocha P | 2014 | J Clin Monit Comput2014，28，： | 1 |
| 16 | Field tests for control of the mound--building termite Comitermes cumulans(Kollar, 1832)(Isoptera: Termiti dae)显示文摘 | Mariconi F A M Galan V B Rocha M T | 1994 | Scientia Agricola1994，51，3： | 1 |
| 17 | An augmented Lagrangian fish swarm based method for global op- timization显示文摘 | Rocha A M A C Martins T F M C Femandes E M G P | 2011 | Journal of Computational and Applied Mathe- matics2011，235，16： | 1 |
| 18 | Lightly Epoxidized Polybutadiene with Efficient Interaction to Precipitated Silica显示文摘 | Jacobi M M Braum M V Rocha T L | | 0，，09： | 1 |
| 19 | Genomic imprinting, growth control and the allocation of nutritional resources: conse- quences for postnatal life 显示文摘 | CHARALAMBOUS M DA ROCHA S T FERGU- SON-SMITH A C | 2007 | Current Opinion in En- docrinology Diabetes and Obesity2007，14，1： | 1 |
| 20 | Microstructural Evolution at the Initial Stages of Continuous Annealing of Cold Rolled Dual Phase Steel显示文摘 | Rocha R O Melo T M F Pereloma E V | 2005 | Materials Science and Engineering A2005，391，12： | 1 |
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