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| 1 | Erythropoietin modulates bone marrow stromal cell differentiation显示文摘Erythropoietin is essential for bone marrow erythropoiesis and erythropoietin receptor on non-erythroid cells including bone marrow stromal cells suggests systemic effects of erythropoietin. Tg6 mice with chronic erythropoietin overexpression have a high hematocrit, reduced trabecular and cortical bone and bone marrow adipocytes, and decreased bone morphogenic protein 2 driven ectopic bone and adipocyte formation. Erythropoietin treatment(1 200 IU·kg–1) for 10 days similarly exhibit increased hematocrit,reduced bone and bone marrow adipocytes without increased osteoclasts, and reduced bone morphogenic protein signaling in the bone marrow. Interestingly, endogenous erythropoietin is required for normal differentiation of bone marrow stromal cells to osteoblasts and bone marrow adipocytes.ΔEpoR_E mice with erythroid restricted erythropoietin receptor exhibit reduced trabecular bone, increased bone marrow adipocytes, and decreased bone morphogenic protein 2 ectopic bone formation. Erythropoietin treated ΔEpoR_E mice achieved hematocrit similar to wild-type mice without reduced bone, suggesting that bone reduction with erythropoietin treatment is associated with non-erythropoietic erythropoietin response. Bone marrow stromal cells from wild-type,Tg6, and ΔEpoR_E-mice were transplanted into immunodeficient mice to assess development into a bone/marrow organ. Like endogenous bone formation, Tg6 bone marrow cells exhibited reduced differentiation to bone and adipocytes indicating that high erythropoietin inhibits osteogenesis and adipogenesis, while ΔEpoR_E bone marrow cells formed ectopic bones with reduced trabecular regions and increased adipocytes, indicating that loss of erythropoietin signaling favors adipogenesis at the expense of osteogenesis. In summary, endogenous erythropoietin signaling regulates bone marrow stromal cell fate and aberrant erythropoietin levels result in their impaired differentiation. | Sukanya Suresh Luis Fernandez de Castro Soumyadeep Dey Pamela G. Robey Constance Tom Noguchi | 2019 | Bone Research2019，7，3： | 5 |
| 2 | Land-walking vs.water-walking interventions in older adults:Effects on aerobic fitness显示文摘Background:Low cardiorespiratory fitness is an independent predictor of all-cause and cardiovascular mortality,and interventions that increase fitness reduce risk.Water-walking decreases musculoskeletal impact and risk of falls in older individuals,but it is unclear whether water-walking improves aerobic fitness in the same way as weight-dependent land-walking.This randomized controlled trial involved 3 intervention groups—a no-exercise control group(CG),a land-walking(LW)group,and a water-walking(WW)group—to investigate the comparative impacts of LWandWWto CG on fitness.Methods:Both exercise groups attended individually tailored,center-based,intensity-matched 3×weekly sessions for 24 weeks,which progressed to 150 min of exercise per week.This was followed by a 24-week no-intervention period.Maximal graded exercise tests were performed on a treadmill at Weeks 0,24,and 48.Results:Maximal oxygen uptake increased from Week 0 to Week 24 in both exercise groups(0.57±0.62 mL/kg/min,0.03±0.04 L/min for LW;0.93±0.75 mL/kg/min,0.06±0.06 L/min for WW,mean±SE)compared to the CG(-1.75±0.78 mL/kg/min,-0.16±0.05 L/min)(group×time,p<0.05).Time to exhaustion increased significantly following LW only(123.4±25.5 s),which was significantly greater(p=0.001)than the CG(24.3±18.5 s).By Week 48,the training-induced adaptations in the exercise groups returned to near baseline levels.Conclusion:Our study supports current physical-activity recommendations that 150 min/week of moderate-intensity exercise produces improvements in fitness in previously sedentary older individuals.Also,LW andWW elicit similar improvements in fitness if conducted at the same relative intensities.Exercise-na?ve older individuals can benefit from the lower impact forces and decreased risk of falls associated withWWwithout compromising improvements in cardiorespiratory fitness. | Andrew Haynes Louise H.Naylor Howard H.Carter Angela L.Spence Elisa Robey Kay L.Cox Barbara A.Maslen Nicola T.Lautenschlager Nicola D.Ridgers Daniel J.Green | 2020 | Journal of Sport and Health Science2020，9，3： | 2 |
| 3 | Integrin-mediated interactions between human bone marrow stromal precursor cells and the extracellular matrix显示文摘 | S Gronthos P.J Simmons S.E Graves P G. Robey | 2001 | Bone2001，，2： | 2 |
| 4 | Reduced expression of DNA topoisomerase I in SF295 human glioblastoma cells selected for resistance to homocamptothecin and diflomotecan显示文摘 | Liao Z Robey R W Guirouilh-Barbat J | 2008 | Mol Pharmaco12008，73，2： | 1 |
| 5 | Accounting for the contradictory consequences of information technology:Theoretical directions and methodological implications显示文摘 | Robey D Boudreau M | 1999 | Information Systems Research1999，10，2： | 1 |
| 6 | Diseases of bone and the stromal cell lineage 显示文摘 | Bianco P Robey PG | 1999 | J Bone Miner Res1999，14，3： | 1 |
| 7 | ABCG2 : a perspective 显示文摘 | Robey RW To KK Polgar O | 2009 | Adv Drug Deliv Rev2009，61，1： | 1 |
| 8 | Bicarbonateincreases tumor pH and inhibits spontaneous metastases显示文摘 | Robey IF Baggett BK Kirkpatrick ND | 2009 | Cancer Res2009，69，： | 1 |
| 9 | Bicarbonate increases tumor pH and inhibits spontaneous metastases 显示文摘 | Robey IF Baggett BK Kirkpatrick ND | 2009 | Cancer Res2009，69，： | 1 |
| 10 | Marrow stromal stem cells显示文摘 | Bianco P Gehron Robey P | | 0，，12： | 1 |
| 11 | Facing up to the ongoing challenge of Kaposi's sarcoma显示文摘 | Robey RC Bower M | 2015 | Curr Opin Infect Dis2015，28，1： | 1 |
| 12 | Passive control of combustion dynamics in stationary gas turbines显示文摘 | Richards G A Straub D L Robey E H | 2003 | Journal of Propulsion and Power2003，19，5： | 1 |
| 13 | Mesenchymal stem cells:Revisiting history,concepts,and assaysl显示文摘 | BIANCO P ROBEY PG SIMMONS PJ | 2008 | Cell Stem Cell2008，2，： | 1 |
| 14 | A functional assay for detection of the mitoxantrone resistance protein, MXR ( ABCG2 ) 显示文摘 | Robey RW Honjo Y Miyake K | 2001 | Biochim Bionhys Acta2001，1512，2： | 1 |
| 15 | Marrow stromal stem cells 显示文摘 | Bianco P Robey PG | 2000 | J Clin Invest2000，105，12： | 1 |
| 16 | Accounting for the Contradictory Organizational Consequences of Information Technology:Theoretical Directions and Methodological Implications显示文摘 | ROBEY D M C BOUDREAU | 1999 | Information Systems Research1999，10，2： | 1 |
| 17 | A CFAR adaptive matched filter detector显示文摘 | Frank C Robey D R F | 1992 | IEEE Transactions on Aerospace and Electronic Systems1992，28，1： | 1 |
| 18 | The generation of internal waves by a towed sphere and its wake in a thermocline显示文摘 | ROBEY H F | 1997 | Phys Fluids1997，9，11： | 1 |
| 19 | Mesenchymal stem cells : revisiting history, concepts, and assays 显示文摘 | Bianco P Robey PG Simmons PJ | 2008 | Cell Stem Cell2008，2，4： | 1 |
| 20 | Causes and consequences of increased glucose metabolism of cancers显示文摘 | Gillies R J Robey I Gatenby R A | 2008 | J Nucl Med2008，49，2： | 1 |
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