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| 1 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 2 | Role of high definition colonoscopy in colorectal adenomatous polyp detection显示文摘AIM:To investigate the rates of polyp detection in a mixed risk population using standard definition (SDC) vs high definition colonoscopes (HDC).METHODS:This was a retrospective cohort comparative study of 3 colonoscopists who each consecutively performed 150 SDC (307,200 pixel) and 150 HDC (792,576 pixels) in a community teaching hospital.RESULTS:A total of 900 colonoscopies were evaluated (mean age 56,46.8% men),450 with each resolution.Polyps of any type were detected in 46.0% of patients using SDC and 43.3% with HDC (P=0.42).There was no significant difference between the overall number of polyps,HDC (397) and SDC (410),detected among all patients examined,(P=0.73).One or more adenomatous polyps were detected in 24.2% of patients with HDC and 24.9% of patients with SDC colonoscopy (P=0.82).There was no significant difference between HDC (M=0.41) and SDC (M=0.42) regarding adenomatous polyp (P=0.88) or advanced adenoma (P=0.56) detection rate among all patients examined.CONCLUSION:HDC did not improve yield of adenomatous polyp,advanced adenoma or overall polyp detection in a population of individuals with mixed risk for colorectal cancer. | Tolga Erim John M Rivas Evelio Velis Fernando Castro | 2011 | World Journal of Gastroenterology2011，17，35： | 2 |
| 3 | Brain tumoral epilepsy : a review 显示文摘 | Riva M | 2005 | Neurol Sci2005，26，5： | 1 |
| 4 | Carbon nanotubes for electrochemical biosensing显示文摘 | Rivas G A Rubianes M D Rodriguez M C | 2007 | Talanta2007，74，3： | 1 |
| 5 | Decreased transcription,expression and function of low-density lipoprotein receptor in leukocytes from patients with systemic lupus erythematosus显示文摘 | Rivas L Zabaleta M Toro F | 2009 | Autoimmunity2009，42，4： | 1 |
| 6 | Computation of the RCS of Complex Bodies Modeled Using NUBBUS Surfaces显示文摘 | Domingo M M Rivas F Perez J | 1995 | IEEE Antennas and Propagation Magazine1995，37，6： | 1 |
| 7 | 显示文摘 | RUBIANES M D RIVAS G A | 2001 | Anal Chim Acta2001，440，2： | 1 |
| 8 | Carbon nanotubes paste electrode 显示文摘 | Rubianes M D Rivas Gustavo A | 2003 | electrochemistry co- mmunications2003，5，： | 1 |
| 9 | Girdling effects on fruit set and quantum yield efficiency of PSII in two Citrus cultivars 显示文摘 | Rivas F Gravina A Agusti M | 2007 | Tree Physiology2007，27，4： | 1 |
| 10 | Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: a systematic review and meta-analysis of the literature显示文摘 | Dentali F Riva N Crowther M | 2012 | Circulation2012，126，： | 1 |
| 11 | Menisci in arrays of cylinders: Numerical simulation by finite elements显示文摘 | Orr F M Scriven L E Rivas A P | 1975 | Journal Of Colloid And Interface Science1975，52，3： | 1 |
| 12 | Emergence of BCR-ABL specific cytotoxic T cells in the bone marrow of patients with Ph+ acute lymphoblastic leukemia during long-term imatinib mesylate treatment显示文摘 | Riva G Luppi M Barozzi P | 2010 | Blood2010，115，8： | 1 |
| 13 | Plant parasiticnematodes associated with guava plantations in Zulia State,Venezuela显示文摘 | Crozzoli P R Casassa P M Rivas G D | 1991 | Fitopatologia Venezolana1991，4，1： | 1 |
| 14 | Kinetics of he-patitis B surface antigen decline during 3 years of telbivudine treatment in hepatitis B e antigen-positive patients显示文摘 | WURSTHORN K JUNG M RIVA A | 2010 | Hepatology2010，52，5： | 1 |
| 15 | Testing for an unusual distribution of rare variants 显示文摘 | Neale B M Rivas M A Voight B F | 2011 | PLoS Genet2011，7，10： | 1 |
| 16 | Kinetics of Hepatitis B Surface Antigen Decline During 3 Years of Telbivudine Treatment in Hepatitis B e Antigen-Positive Patients显示文摘 | Wursthorn K Jung M Riva A et at | 2010 | Hepatology2010，52，5： | 1 |
| 17 | Double sleeve uniportal video-assisted thoracoscopic lobectomy for non-small cell lung cancer 显示文摘 | GONZALEZ'-RIVAS D DELGADO M FIEIRA E | 2014 | Ann Car- diothorac Surg2014，3，2： | 1 |
| 18 | Genotoxieity study of water-soluble cationic polymers and their polymer-metal complexes with biocidal activity显示文摘 | Rivas B L Pereira E D Mondaca M A | 2003 | J Appl Polym Sci2003，87，3： | 1 |
| 19 | A fuzzy expert system application to the evaluation of ceramic-and paperquality kaolin 显示文摘 | Taboada J Rivas T Saavedra M A | 2006 | Applied Clay Science2006，，33： | 1 |
| 20 | Arobust method to obtain optimal and sub-optimal design and retrofit solutions of water utilization systems with multiple contaminants in process plants显示文摘 | Bagajewicz M J Rivas M Savelski M J | 2000 | Computers and Chemical Engineering2000，24，： | 1 |
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