|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | 多重结局的多元Meta分析和多重治疗的网状Meta分析:原理、概念及实例显示文摘英国国家健康与临床优选研究所(NICE)等组织需要对现有研究获得的证据进行整合来指导决策,需要确定关于多重疗效及安全性结局的最佳治疗。但是,相关的研究不一定对所有关注的治疗或结局都进行了直接比较,多元Meta分析及网状Meta分析为如何确定最佳治疗这一问题提供了思路,该方法不仅考虑了直接证据,还利用了关联或间接的证据。本文中,研究者描述了这些方法学的重要概念及假设,并阐述关联及间接证据如何产生,同时通过图表说明这些证据在涉及多重结局和多重治疗的真实临床案例中如何使用。 | Richard D Riley Dan Jackson Georgia Salanti Danielle L Burke Malcolm Price Jamie Kirkham Ian R White 孙至佳(译) 张岩(译) 刘雪晴(译) 杨智荣(校) 孙凤(校) | 2018 | 英国医学杂志中文版2018，21，12： | 2 |
| 3 | Frequency content of whole body gait kinematic data 显示文摘 | Angeloni C Riley P Krebs D | 1994 | IEEE Transactions on Rehabilitation Engineering1994，2，1： | 1 |
| 4 | 2-D multiple reflections显示文摘 | Riley D C Claerbout J F | 1976 | Geophysics1976，41，4： | 1 |
| 5 | Observation of the autumn migration of the rice leaf roller Cnahalocrocis medinalis (Lepidoptera: Pyralidae) and other moths in eastern china 显示文摘 | Riley J R Reynolds D R Smith A D | 1995 | Bull Ent Res1995，85，： | 1 |
| 6 | Assessment of single nuclcofide polymorphisms in genes residing on chromosomes 14 and 29 for associa- tion with carcass composition traits in Bos indicus cattle显示文摘 | Casas E White S N Riley D G | 2005 | Journal of Animal Science2005，83，： | 1 |
| 7 | In-situ neutron diffraction of titanium silicide TisSi3 during self-propagating high-temperature synthesis显示文摘 | Riley D P Oliver C P Kisi E H | 2006 | Intermetallic2006，，14： | 1 |
| 8 | A systematic review of molecular and biological tumor markers in neuroblastoma 显示文摘 | Riley RD Heney D Jones Dr | 2004 | Clin Cancer Res2004，10，11： | 1 |
| 9 | Salvinorin Aproduces cerebrovasodilation through activation of nitricsensitive potassium channel显示文摘 | SU D RILEY J KIESSLING W J | 2011 | Anesthesiology2011，114，2： | 1 |
| 10 | CIMO Ligand (CD154) triggers ashort-term CD4+ T cell aetivition response that results in secretion of immunomodulatory cytokines and apoptosis显示文摘 | Blair P J Riley J L Harlan D M | 2000 | J Exp Med2000，191，4： | 1 |
| 11 | Decreased thin filament density and length in human atrophic soleus muscle fibers after spaceflight显示文摘 | Riley D A Bain J L Thompson J L | 2000 | J Appl Physiol2000，88，2： | 1 |
| 12 | Decreased El2 and/or E47 transcription factor activity in the bone marrow as well as in the spleen of aged mice显示文摘 | Frasca D Nguyen D Riley RL | 2003 | J Immunol2003，170，2： | 1 |
| 13 | Replication of association between schizophrenia and ZNFS04A in the Irish case-control stud- y of schizophrenia sample显示文摘 | Riley B Thiselton D Mahcr BS | 2009 | Molecular Psychiatry2009，15，： | 1 |
| 14 | Salvinorin Apretreatment preserves cerebrovascular autoregulation afterbrain hypoxic/ischemic injury via extracellular signal-regulated kinase/mitogen-activated protein kinase in piglets显示文摘 | SU D RILEY J ARMSTEAD W M | 2012 | Anesth Analg2012，114，1： | 1 |
| 15 | Preparation and alcohol oxidation studies of the ferrate ( Ⅵ ) iron 显示文摘 | WILLIAS D H RILEY J T | 1974 | Inorg Chim Acta1974，，8： | 1 |
| 16 | A close look at the bacteriology of nitrification 显示文摘 | Hagopian D S Riley J G | | Water Res0，29，10： | 1 |
| 17 | An evaluation of an autothermal aerobic digestion system显示文摘 | Riley D W Forster C F | 2002 | Process Safety and Environmental Protection2002，80，2： | 1 |
| 18 | Intrathecal sufentanil for labor analgesia dose not cause a sympathectomy 显示文摘 | Riley ET Walker D Hamilton Ci | 1997 | Anesthesiology1997，87，： | 1 |
| 19 | New Project Procurement Process 显示文摘 | BROWN D C ASHLEIGH J M RILEY M J | 2001 | Journal of Management in Engineering2001，17，4： | 1 |
| 20 | The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes 显示文摘 | Floudas D Binder M Riley R | 2012 | Science2012，336，6089： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员