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| 1 | Interplay between nitric oxide and VIP in CCK-8-induced phasic contractile activity in the rabbit sphincter of Oddi显示文摘AIM: The sphincter of Oddi (SO) plays an important role in delivery of bile into the duodenum. To establish whether vasoactive intestinal polypeptide (VIP) and nitric oxide (NO) were involved in phasic contractile activity of the rabbit SO stimulated by cholecystokinin-octapeptide (CCK-8).METHODS: Isolated SO muscle rings were cleaned of fat and mounted horizontally on two small L-shaped hooksone of which was connected to a force transducer for the measurement of isometric tension. The experiments were carried out in a thermostatically controlled (37±0.2℃)organ bath (5 mL) containing Krebs solution. The organ fluid was gassed with 95% O2 and 50 mL/L CO2 to keep the pH at 7.40±0.05. Contractile responses to CCK-8 (1μmol/L) were evaluated in the presence and absence of N^G-nitro-L-arginine (LNNA), an inhibitor of NO synthase (100μmol/L), and (p-chloro-D-Phe^6-Leu^17)-VIP (VIPa,30μmol/L), a VIP receptor antagonist.RESULTS: CCK-8 stimulated the phasic activity of the SO.NO synthase inhibition increased the frequency and amplitude of contractions with a slight increase in developed tension.Pre-incubation with VIPa also attenuated this CCK-8 effect.The combined application of LNNA and VIPa abolished the phasic activity of the muscle rings with a marked increase in tension in response to CCK-8.CONCLUSION: VIP and NO together contribute to an increase in phasic activity of SO. | Attila Pálv(o|¨)lgyi Réka Sári József Németh Annamária Szabolcs István Nagy Péter Hegyi János Lonovics Zoltán Szilvássy | 2005 | World Journal of Gastroenterology2005，11，21： | 11 |
| 2 | L-arginine-induced experimental pancreatitis显示文摘Despite medical treatment, the lethality of severe acute pancreatitis is still high (20-30%). Therefore, it is very important to find good animal models to characterise the events of this severe disease. In 1984, Mizunuma et. al. developed a new type of experimental necrotizing pancreatitis by intraperitoneal administration of a high dose of L-arginine in rats. This non-invasive model is highly reproducible and produces selective, dose-dependent acinar cell necrosis.Not only is this a good model to study the pathomechanisne of acute necrotizing pancreatitis, but it is also excellent to observe and influence the time course changes of the disease. By writing this review we iluminate some new aspects of cell physiology and pathology of acute necrotizing pancreatitis. Unfortunately, the reviews about acute experimental pancreatitis usually did not discuss this model.Therefore, the aim of this manuscript was to summarise the observations and address some challenges for the future in L-arginine-induced pancreatitis. | PéterHegyi ZoltánRakonczayJr RékaSári CsabaGóg JánosLonovics TamásTakács LászlóCzakó | 2004 | World Journal of Gastroenterology2004，10，14： | 7 |
| 3 | Compared efficacy of preservation solutions on the outcome of liver transplantation:Meta-analysis显示文摘AIM To compare the effects of the four most commonly used preservation solutions on the outcome of liver transplantations.METHODS A systematic literature search was performed using MEDLINE, Scopus, EMBASE and the Cochrane Library databases up to January 31^(st), 2017. The inclusion criteria were comparative, randomized controlled trials(RCTs) for deceased donor liver(DDL) allografts with adult and pediatric donors using the gold standard University of Wisconsin(UW) solution or histidinetryptophan-ketoglutarate(HTK), Celsior(CS) and Institut Georges Lopez(IGL-1) solutions. Fifteen RCTs(1830 livers) were included; the primary outcomes were primary non-function(PNF) and one-year posttransplant graft survival(OGS-1). RESULTS All trials were homogenous with respect to donor and recipient characteristics. There was no statistical difference in the incidence of PNF with the use of UW, HTK, CS and IGL-1(RR = 0.02, 95%CI: 0.01-0.03, P = 0.356). Comparing OGS-1 also failed to reveal any difference between UW, HTK, CS and IGL-1(RR = 0.80, 95%CI: 0.80-0.80, P = 0.369). Two trials demonstrated higher PNF levels for UW in comparison with the HTK group, and individual studies described higher rates of biliary complications where HTK and CS were used compared to the UW and IGL-1 solutions. However, the meta-analysis of the data did not prove a statistically significant difference: the UW, CS, HTK and IGL-1 solutions were associated with nearly equivalent outcomes.CONCLUSION Alternative solutions for UW yield the same degree of safety and effectiveness for the preservation of DDLs, but further well-designed clinical trials are warranted. | Agnes Lilla Szilágyi Péter Mátrai Péter Hegyi Eszter Tuboly Daniella Pécz András Garami Margit Solymár Erika Pétervári Márta Balaskó Gábor Veres László Czopf Bastian Wobbe Dorottya Szabó Juliane Wagner Petra Hartmann | 2018 | World Journal of Gastroenterology2018，24，16： | 5 |
| 4 | Relevance of α-defensins(HNP1-3) and defensin β-1 in diabetes显示文摘AIM: To investigate the genetic background of human defensin expression in type 1 and 2 diabetes.METHODS: Associations between DEFA1/DEFA3 gene copy number polymorphism and diabetes as well as between the promoter polymorphisms of DEFB1 and diabetes were studied. The copy number variation of the DEFA1/DEFA3 genes was determined in 257 diabetic patients(117 patients with type 1 and 140 with type 2 diabetes). The control group consisted of 221 age- and gender-matched healthy blood donors. The cumulative copy numbers of the DEFA1/DEFA3 genes were detected by using quantitative PCR analysis. To evaluate the HNP 1-3(human neutrophil peptide 1-3 or α-defensin) levels in the circulation, plasma HNP 1-3 concentrations were measured by ELISA. The expression of DEFA1/A3 in peripheral leukocytes of the diabetic patients was measured by quantitative RT PCR analysis. Three SNPs of the human DEFB1(human defensin β-1) gene: DEFB1 G-20A(rs11362), DEFB1 C-44G(rs1800972) and DEFB1 G-52A(rs1799946) were genotyped by Custom TaqMan? Real Time PCR assay.RESULTS: Significant differences were observed in HNP1-3 levels between the healthy subjects and both groups of diabetic patients. The mean ± SE was 28.78 ± 4.2 ng/mL in type 1 diabetes, and 29.82 ± 5.36 ng/mL in type 2 diabetes, vs 11.94 ± 2.96 ng/mL in controls; P < 0.01 respectively. There was no significant difference between patients with type 1 and type 2 diabetes in the high plasma concentrations of HNP1-3. The highest concentrations of α-defensin were found in diabetic patients with nephropathy(49.4 ± 4.8 ng/mL), neuropathy(38.7 ± 4.8 ng/mL) or cardiovascular complications(45.6 ± 1.45 ng/L). There was no significant difference in the cumulative copy numbers of DEFA1/DEFA3 genes between controls and patients, or between patients with the two types of diabetes. Comparisons of HNP 1-3 plasma level and DEFA1/A3 copy number of the same patient did not reveal significant relationship between defensin-α levels and the gene copy numbers(r2 = 0.01). Similarly, no positive correlation was observed between the copy numbers and the mRNA expression levels of DEFA1/A3. Regarding the C-44G polymorphism of DEFB1, the GG 'protective' genotype was much less frequent(1%-2%) among both groups of patients than among controls(9%).CONCLUSION: Elevated HNP1-3 levels in diabetes are independent of DEFA1/DEFA3 copy numbers, but GG genotype of C-44G SNP in DEFB1 gene may result in decreased defensin β-1 production. | Balázs Csaba Németh Tamás Várkonyi Ferenc Somogyvári Csaba Lengyel Katalin Fehértemplomi Szabolcs Nyiraty Péter Kempler Yvette Mándi | 2014 | World Journal of Gastroenterology2014，20，27： | 4 |
| 5 | Risks and Predictors of Blood Transfusion in Pediatric Patients Undergoing Open Heart Operations显示文摘 | Andrea Székely Zsuzsanna Cserép Erzsébet Sápi Tamás Breuer Csaba A. Nagy Péter Vargha István Hartyánszky András Szatmári András Treszl | 2009 | The Annals of Thoracic Surgery2009，，1： | 2 |
| 6 | Translational mini-review series on TH17 cells: induction of interleukin-17 production by regu- latory T cells显示文摘 | Afzali B Mitehell P Lechler RI | 2010 | Clin Exp Immunol2010，159，2： | 1 |
| 7 | A new mutation in the gene for lysosomal acid lipase leads to Wolman disease in an African kindred显示文摘 | Ries S Aslanidis C Fehringer P | | 0，，08： | 1 |
| 8 | The effect of repeated isoflurane anesthesia on spatial and psychomotor performance in young and aged mice显示文摘 | Butterfield NN Graf P Ries CR | | 0，，05： | 1 |
| 9 | Life cycle assessment of residential heating and cooling systems in four regions in the United States显示文摘 | Shah V P Debella D C Ries R J | 2008 | Energy and Buildings2008，40，4： | 1 |
| 10 | Chronic subdural hematoma:surgical treatment and outcome in 104 patients 显示文摘 | Ernestus RI Beldzinski P Lanfermann H | 1997 | Surg Neurol1997，48，3： | 1 |
| 11 | Chronic subdural hematoma:surgial treatment and outcome in 104 patients显示文摘 | Emestns RI Beldzinski P Lanfermann H | 1997 | Surg Neurol1997，48，3： | 1 |
| 12 | 显示文摘 | Clèries L Morenza J L | 1996 | Applied Surface Science1996，9698，： | 1 |
| 13 | Chronic subdural hematomasurgical treatment and outcome in 104 patient显示文摘 | Ernestus RI Beldzinski P Lanfermann H | 1997 | Surg Neurol1997，48，： | 1 |
| 14 | The Tdmx tran scription factor Brachyury promotes epithelial-mesenchymal transition in human tumor eells显示文摘 | Fernando RI Litzinger M Trono P | 2010 | J Clin Invest2010，120，2： | 1 |
| 15 | Sulfona- mide-1, 2, 4-triazole derivatives as antifungal and antibacterial agents: synthesis, biological evaluation, lipophilicity, and con-formational studies 显示文摘 | Ezabadi RI Camoutsis C Zoumpoulakis P | 2008 | Bioorg Med Chem2008，16，3： | 1 |
| 16 | Pathogenesis and treatment of idiopathic nephrotic syndrome in adults 显示文摘 | SAHALI D AUDARD V RI~MY P | 2012 | Nephrol Ther2012，8，3： | 1 |
| 17 | PeroxisomaI pro liferator-activated receptora-dependent inhibition of endo thelial cell proliferation and tumorigenesis显示文摘 | Ambra P Maria RI Arnaldo EG | 2007 | Bioehemis try2007，24，17： | 1 |
| 18 | Leaf senes-cence and lipid peroxidation:effect of some phytohormones andscavengers of free radicals and singlet oxygen显示文摘 | DHINDSA R S PLUMB-DHINDSA P L RIED D M | 1982 | Physiol Plant1982，56，： | 1 |
| 19 | The effect of repeatedisoflurane anesthesia on spatial and psychomotor performance inyoung and aged mice显示文摘 | Butterfield NN Graf P Ries C | 2004 | Anesth Analg2004，98，5： | 1 |
| 20 | An employer-based, pharmacist intervention model/or patients with type 2 diabetes 显示文摘 | Iyer RI Coderre P McKelvey T | 2010 | Am J Health Syst Pharm2010，67，4： | 1 |
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