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| 1 | 长春市儿童医院1998~2001年婴幼儿杯状病毒腹泻流行病学研究显示文摘人类杯状病毒(humancalicivirus,HuCV)是引起儿童和成人非菌性胃肠炎的主要病原之一。为了掌握HuCV在我国的流行情况,1998年7月至2001年6月,从长春市儿童医院2343例5岁以下腹泻患儿中共收集粪便标本1264份,其中1056份来自2135例住院患儿。对轮状病毒检测为阴性的588份标本,经多价酶免疫试验(EIA)和两组引物反转录-聚合酶链反应(RT-PCR)检测HuCV,202份为阳性,其中住院患儿标本178份,HuCV检出率为16 9%。HuCV腹泻以2岁以下儿童为主(占96%),流行高峰季节为11月至次年3月。选择17株HuCV进行分子鉴定,15株属GⅡ 4群,1株属GⅡ 3群,另1株属GⅠ 2群,表明GⅡ 4群HuCV是我国流行的优势株。根据HuCV住院患儿的监测资料初步估计,HuCV腹泻住院率约为0 5‰~2 4‰。讨论了长春地区HuCV的流行趋势和疾病负担。以上结果为我国HuCV腹泻的预防和控制提供了科学依据。 | 谢华萍 方肇寅 王光 孙利炜 吕红霞 Zhong WM Tai JH 林思恩 童志礼 章青 Glass RI Jiang X | 2002 | 病毒学报2002，18，4： | 75 |
| 2 | 考虑电力业务重要性的电力通信网关键节点识别显示文摘为了能够准确辨识出电力通信网的关键节点,给出了一种识别电力通信网关键节点的分析方法。首先,通过分析电力业务对电力通信网的要求和对电力网的影响,建立多层评估模型,采用量化赋值的方式对评价指标进行量化处理,提出针对非对称不完全层次结构的层次分析法和基于云模型原理的改进熵权法,建立电力业务综合重要度评估体系;其次,结合实际电力业务分布情况建立加权网络,通过改进的权值降低法识别网络关键节点;最后,通过对两个实际电力通信网络的仿真验证了该方法的正确性。 | 李昌超 康忠健 于洪国 郑世超 Ri Kihong | 2019 | 电工技术学报2019，34，11： | 37 |
| 3 | Ultrafast laser processing of materials: from science to industry显示文摘Processing of materials by ultrashort laser pulses has evolved significantly over the last decade and is starting to reveal its scientific,technological and industrial potential.In ultrafast laser manufacturing,optical energy of tightly focused femtosecond or picosecond laser pulses can be delivered to precisely defined positions in the bulk of materials via two-/multi-photon excitation on a timescale much faster than thermal energy exchange between photoexcited electrons and lattice ions.Control of photoionization and thermal processes with the highest precision,inducing local photomodification in sub-100-nm-sized regions has been achieved.State-of-the-art ultrashort laser processing techniques exploit high 0.1–1μm spatial resolution and almost unrestricted three-dimensional structuring capability.Adjustable pulse duration,spatiotemporal chirp,phase front tilt and polarization allow control of photomodification via uniquely wide parameter space.Mature opto-electrical/mechanical technologies have enabled laser processing speeds approaching meters-per-second,leading to a fast lab-to-fab transfer.The key aspects and latest achievements are reviewed with an emphasis on the fundamental relation between spatial resolution and total fabrication throughput.Emerging biomedical applications implementing micrometer feature precision over centimeter-scale scaffolds and photonic wire bonding in telecommunications are highlighted. | Mangirdas Malinauskas Albertas Žukauskas Satoshi Hasegawa Yoshio Hayasaki Vygantas Mizeikis Ričardas Buividas Saulius Juodkazis | 2016 | Light(Science & Applications)2016，5，1： | 37 |
| 4 | Petawatt and exawatt class lasers worldwide显示文摘In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has developed.We are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under construction.In addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR facilities.So apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development. | Colin N.Danson Constantin Haefner Jake Bromage Thomas Butcher Jean-Christophe FChanteloup Enam A.Chowdhury Almantas Galvanauskas Leonida A.Gizzi Joachim Hein David I.Hillier Nicholas W.Hopps Yoshiaki Kato Efim A.Khazanov Ryosuke Kodama Georg Korn Ruxin Li Yutong Li Jens Limpert Jingui Ma Chang Hee Nam David Neely Dimitrios Papadopoulos Rory R.Penman Liejia Qian Jorge J.Rocca andrey A.Shaykin Craig W.Siders Christopher Spindloe Sándor Szatmári Raoul M.G.M.Trines Jianqiang Zhu Ping Zhu Jonathan D.Zuegel | 2019 | High Power Laser Science and Engineering2019，7，3： | 33 |
| 5 | 北京友谊医院1998~2001年轮状病毒哨点监测分析显示文摘目的 了解 5岁以下儿童中以医院为基础的轮状病毒流行情况。方法 按WHO轮状病毒监测的通用方法 (CID 98)进行 ,轮状病毒检测采用聚丙烯酰胺凝胶电泳 /酶联免疫吸附试验(ELISA)。毒株分型用ELISA/逆转录聚合酶链反应。结果 从 1998年 4月至 2 0 0 1年 3月收集的4 84份腹泻患儿粪便标本中 ,检出阳性标本 12 3份 ,总的轮状病毒感染检出率为 2 5 .4 % ,住院和门诊患儿检出率分别是 31.6 %和 2 7.3% ,而在轮状病毒流行季节 ,则可以引起高达 4 6 .2 %急性腹泻住院率。腹泻患儿发病呈现两个明显的季节高峰 :一个由细菌性痢疾引起的夏季 (6~ 9月 )发病高峰 ,另一个是轮状病毒感染腹泻造成的秋冬季 (10~ 12月 )发病高峰。轮状病毒感染 96 .8%发生于 3岁以下幼儿 ,主要在 6~ 11月龄 (38.2 % )和 1~ 2岁 (2 8.5 % )年龄组 ,轮状病毒感染率在 6~ 35月龄年龄段最高。流行的轮状病毒G血清型依次为G1(5 5 .3% )、G2 (2 6 .8% )、G3(9.8% )和G4 (0 .8% ) ,没有发现G9型 ,10份 (8.1% )标本未能分型 ,混合感染 (0 .8% )罕见。结论 轮状病毒腹泻是北京市儿童的重要传染病 ,开发应用安全有效的轮状病毒疫苗将对减轻轮状病毒疾病负担有重要作用。 | 童志礼 马莉 章菁 侯安存 郑丽舒 金宗平 谢华萍 马兰 张丽杰 Ivanoff B Glass RI Bresee JS JIANG Xi Kilgore PE 方肇寅 | 2003 | 中华流行病学杂志2003，24，12： | 27 |
| 6 | Dynamics modeling and control of a transport aircraft for ultra-low altitude airdrop显示文摘The nonlinear aircraft model with heavy cargo moving inside is derived by using the separation body method, which can describe the influence of the moving cargo on the aircraft attitude and altitude accurately. Furthermore, the nonlinear system is decoupled and linearized through the input–output feedback linearization method. On this basis, an iterative quasi-sliding mode(SM)flight controller for speed and pitch angle control is proposed. At the first-level SM, a global dynamic switching function is introduced thus eliminating the reaching phase of the sliding motion.At the second-level SM, a nonlinear function with the property of ‘‘smaller errors correspond to bigger gains and bigger errors correspond to saturated gains' ' is designed to form an integral sliding manifold, and the overcompensation of the integral term to big errors is weakened. Lyapunovbased analysis shows that the controller with strong robustness can reject both constant and time-varying model uncertainties. The performance of the proposed control strategy is verified in a maximum load airdrop mission. | Liu Ri Sun Xiuxia Dong Wenhan | 2015 | Chinese Journal of Aeronautics2015，28，2： | 25 |
| 7 | 长春市儿童医院1998~2001年轮状病毒哨点监测分析显示文摘目的 为在中国开发和应用轮状病毒疫苗提供流行病学背景资料。方法 以医院为基础的哨点监测 ,在长春市儿童医院 5岁以下腹泻患儿中进行 ,收集患儿临床资料和粪便标本 ,轮状病毒检测用聚丙烯酰胺凝胶电泳 (PAGE)和 或酶联免疫吸附试验 (ELISA) ,毒株分型用ELISA和 或逆转录 聚合酶链反应 (RT PCR)。所有资料录入计算机进行数据分析。结果 3年监测中共调查 2 3 4 3例腹泻患儿 ,收集便样 12 11份 ,轮状病毒检出率门诊患儿和住院患儿分别为 3 1.0 %和 52 .9%。轮状病毒感染 95.0 %发生于 2岁以下儿童。每年寒冷季节流行 (11月到次年 3月 )。流行的轮状病毒G血清型依次为G1(82 .4% )、G2 (5.0 % )、G3 (3 .3 % )和G 4(0 .9% ) ,P基因型以P[8]和P[4]为常见。共检出 9种P~G结合的毒株 ,其中世界常见的 4种流行株占 75.6%。结论 轮状病毒流行毒株呈现超常多样性 。 | 孙利炜 童志礼 李丽红 章菁 陈琦 郑丽舒 刘静 谢华萍 王承训 张丽杰 Ivanoff B Glass RI Bresee JS Jiang XI Kilgore PE 方肇寅 | 2003 | 中华流行病学杂志2003，24，11： | 25 |
| 8 | Plasmonic nano-printing: large-area nanoscale energy deposition for efficient surface texturing显示文摘The lossy nature of plasmonic wave due to absorption is shown to become an advantage for scaling-up a large area surface nanotexturing of transparent dielectrics and semiconductors by a self-organized sub-wavelength energy deposition leading to an ablation pattern—ripples—using this plasmonic nano-printing.Irreversible nanoscale modifications are delivered by surface plasmon polariton(SPP)using:(i)fast scan and(ii)cylindrical focusing of femtosecond laser pulses for a high patterning throughput.The mechanism of ripple formation on ZnS dielectric is experimentally proven to occur via surface wave at the substrate–plasma interface.The line focusing increase the ordering quality of ripples and facilitates fabrication over wafer-sized areas within a practical time span.Nanoprinting using SPP is expected to open new applications in photo-catalysis,tribology,and solar light harvesting via localized energy deposition rather scattering used in photonic and sensing applications based on re-scattering of SPP modes into far-field modes. | Lei Wang Qi-Dai Chen Xiao-Wen Cao Ričardas Buividas Xuewen Wang Saulius Juodkazis Hong-Bo Sun | 2017 | Light(Science & Applications)2017，6，1： | 15 |
| 9 | Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: Clinico-pathogenic aspects显示文摘Toll-like receptors (TLRs) recognize specific motifs which are frequently present in bacteria, fungi, prokaryotes and viruses. Amongst TLRs, TLR9 can be activated by such bacterial or viral DNA fragments, immunoglobulin-DNA complexes or synthetic oligonucleotides, which all contain unmethylated cytosineguanine nucleotide sequences (CpGs). Emerging data indicate that TLR9 signaling has a role in, and may influence, colorectal carcinogenesis and colonic inflammation. CpGs are classified into three groups according to their influence on both the antigen-specific humoraland cellular immunity, and the production of type 1 interferons and proinflammatory cytokines. TLR9 activation via CpGs may serve as a new therapeutic target for several cancerous and various inflammatory conditions. Due to its probable anti-cancer effects, the application possibilities of TLR9-signaling modulation may be extremely diverse even in colorectal tumors. In this review we aimed to summarize the current knowledge about TLR-signaling in the pathogenesis and therapy of inflammatory bowel diseases and colorectal cancer. Due to the species-specific differences in TLR9 expression, however, one must be careful in translating the animal model data into the human system, because of the differences between CpG-oligodeoxynucleotide-responsive cells. TLR9 agonist DNA-based immunomodulatory sequences could also represent a promising therapeutic alternative in systemic inflammatory conditions and chronic colonic inflammations as their side effects are not significant. | István Fri Ferenc Sipos Tiana M Germann Alexandra Kalmár Zsolt Tulassay Béla Molnár Gyrgyi Mzes | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 10 | Molecular Typing of Brucella Suis Collected from 1960s to 2010s in China by MLVA and PFGE显示文摘Brucellosis is a bacterial anthropozoonosis usually caused by Brucella abortus, Brucella melitensis, Brucella suis and Brucella canis. Brucella suis, the causative agent of swine brucellosis, is classified into five biovars and preferentially infects different animal hosts [1] . | LI Zhen Jun CUI Bu Yun CHEN Hai CHEN Jing Diao ZHAO Hong Yan PIAO Dong Ri JIANG Hai ZHANG Li TANG Xu KE Chang Wen YAO zhen TIAN Guo Zhong | 2013 | Biomedical and Environmental Sciences2013，26，6： | 13 |
| 11 | 基于BP人工神经网络的生化处理水水质预测显示文摘神经网络具有强大的非线性映射能力和并行处理能力,近年来在水处理领域中被广泛地应用。利用神经网络算法对某污水处理厂的污水处理系统进行了出水水质预测。结果表明,基于BP神经网络的水质预测模型拟合效果较好,模拟出来的化学需氧量(COD)、pH、固体悬浮物(SS)及生物需氧量(BOD)的数值范围均较接近于实际值,其平均相对标准差分别为6.96%、1.31%、12.09%、15.18%。 | RI Son-il 侯德刚 张振家 周伟丽 迟莉娜 CHOE Won-il | 2009 | 现代化工2009，29，12： | 12 |
| 12 | Interplay between nitric oxide and VIP in CCK-8-induced phasic contractile activity in the rabbit sphincter of Oddi显示文摘AIM: The sphincter of Oddi (SO) plays an important role in delivery of bile into the duodenum. To establish whether vasoactive intestinal polypeptide (VIP) and nitric oxide (NO) were involved in phasic contractile activity of the rabbit SO stimulated by cholecystokinin-octapeptide (CCK-8).METHODS: Isolated SO muscle rings were cleaned of fat and mounted horizontally on two small L-shaped hooksone of which was connected to a force transducer for the measurement of isometric tension. The experiments were carried out in a thermostatically controlled (37±0.2℃)organ bath (5 mL) containing Krebs solution. The organ fluid was gassed with 95% O2 and 50 mL/L CO2 to keep the pH at 7.40±0.05. Contractile responses to CCK-8 (1μmol/L) were evaluated in the presence and absence of N^G-nitro-L-arginine (LNNA), an inhibitor of NO synthase (100μmol/L), and (p-chloro-D-Phe^6-Leu^17)-VIP (VIPa,30μmol/L), a VIP receptor antagonist.RESULTS: CCK-8 stimulated the phasic activity of the SO.NO synthase inhibition increased the frequency and amplitude of contractions with a slight increase in developed tension.Pre-incubation with VIPa also attenuated this CCK-8 effect.The combined application of LNNA and VIPa abolished the phasic activity of the muscle rings with a marked increase in tension in response to CCK-8.CONCLUSION: VIP and NO together contribute to an increase in phasic activity of SO. | Attila Pálv(o|¨)lgyi Réka Sári József Németh Annamária Szabolcs István Nagy Péter Hegyi János Lonovics Zoltán Szilvássy | 2005 | World Journal of Gastroenterology2005，11，21： | 11 |
| 13 | 一种识别电力系统关键输电线路的方法显示文摘电网关键输电线路的辨别有利于预防电网灾难事故,提高电力系统的安全稳定性。通过评估支路开断后系统潮流所受冲击的强弱,给出一种识别电力系统关键输电线路的方法。首先,基于等相角线理论,定义相角分割区,依据相角分割区和电气距离对系统输电线路进行分区,基于广义熵指数理论,定义潮流增长率广义熵指数指标,评估支路开断后潮流冲击分布的均衡度;然后,从网络拓扑结构的角度,定义边的Katz-Bonacich中心性指标评估输电线路位置的重要性,并定义评估系统对潮流冲击抵抗能力的余度指标;最后,基于云模型原理,对各评估指标进行云模型转换,以云图的形式展现评估结果。通过对IEEE 30节点系统和新英格兰10机39节点系统进行仿真,验证了所提方法的正确性。 | 康忠健 李昌超 于洪国 郑世超 Ri Kihong | 2020 | 电力自动化设备2020，40，4： | 10 |
| 14 | Generation of hircine-induced pluripotent stem cells by somatic cell reprogramming显示文摘 | Jiangtao Ren Yongjun Pak Lixiazi He Lei Qian Yijun Gu Hui Li Lingjun Rao Jing Liao Chun Cui Xun Xu Jinqiu Zhou Hakchol Ri Lei Xiao | 2011 | Cell Research2011，21，5： | 10 |
| 15 | Primary liver cancer: Worldwide incidence and trends显示文摘 | F.Xavier Bosch Josepa Ribes Mireia Díaz Ramon Cléries | 2004 | Gastroenterology2004，，5： | 10 |
| 16 | Contribution of TLR signaling to the pathogenesis of colitisassociated cancer in inflammatory bowel disease显示文摘In the intestine a balance between proinflammatory and repair signals of the immune system is essential for the maintenance of intestinal homeostasis. The innate immunity ensures a primary host response to microbial invasion, which induces an inflammatory process to localize the infection and prevent systemic dissemination of pathogens. The key elements of this process are the germline encoded pattern recognition receptors inclu-ding Toll-like receptors(TLRs). If pathogens cannot be eliminated, they may elicit chronic inflammation, which may be partly mediated via TLRs. Additionally, chronic inflammation has long been suggested to trigger tissue tumorous transformation. Inflammation, the seventh hallmark of cancer, may affect all phases of tumor development, and evade the immune system. Inflammation acts as a cellular stressor and may trigger DNA damage or genetic instability. Furthermore, chronic inflammation can provoke genetic mutations and epigenetic mechanisms that promote malignant cell transformation. Colorectal cancers in inflammatory bowel disease patients are considered typical examples of inflammation-related cancers. Although data regarding the role of TLRs in the pathomechanism of cancer-as-sociated colitis are rather conflicting, functionally these molecules can be classified as 'largely antitumorigenic' and 'largely pro-tumorigenic' with the caveat that the underlying signaling pathways are mainly context(i.e., organ-, tissue-, cell-) and ligand-dependent. | Ferenc Sipos István Fri Miklós Constantinovits Zsolt Tulassay Gyrgyi Mzes | 2014 | World Journal of Gastroenterology2014，20，36： | 9 |
| 17 | Error analysis of the semi-discrete local discontinuous Galerkin method for semiconductor device simulation models显示文摘In this paper we continue our effort in Liu-Shu (2004) and Liu-Shu (2007) for developing local discontinuous Galerkin (LDG) finite element methods to discretize moment models in semiconductor device simulations. We consider drift-diffusion (DD) and high-field (HF) models of one-dimensional devices, which involve not only first derivative convection terms but also second derivative diffusion terms, as well as a coupled Poisson potential equation. Error estimates are obtained for both models with smooth solutions. The main technical difficulties in the analysis include the treatment of the inter-element jump terms which arise from the discontinuous nature of the numerical method, the nonlinearity, and the coupling of the models. A simulation is also performed to validate the analysis. | LIU YunXian 1, & SHU Chi-Wang 2 1 School of Mathematics, Shandong University, Jinan 250100, China 2 Division of Applied Mathematics, Brown University, Providence, RI 02912, USA | 2010 | Science China Mathematics2010，53，12： | 8 |
| 18 | Facile and efficient synthesis of quinoline-4-carboxylic acids under microwave irradiation显示文摘A facile and efficient method for the preparation of 2-non-substituted quinoline-4-carboxylic acids is described via the Pfitzinger reaction of isatins with sodium pyruvate following consequent decarboxylation under microwave irradiation. | Zhu, Hui Yang, Ri Fang Yun, Liu Hong Li, Jin | 2010 | Chinese Chemical Letters2010，21，1： | 8 |
| 19 | 针对Terra/MODIS数据的改进分裂窗地表温度反演算法(英文)显示文摘针对Terra/MODIS数据提出改进的分裂窗地表温度反演算法。充分考虑了传感器观测角度(VZA)的影响,并对地表和有效大气辐射按照不同的亮度温度区间分别进行Planck函数简化。利用TIGR3大气廓线库中的875条晴空大气廓线,ASTER波谱库中的106条地物发射率波谱,结合MODTRAN4大气辐射传输模型模拟得到分裂窗算法系数。利用MODTRAN4模拟数据对算法精度进行验证,结果表明本文的改进算法和原算法的均方根误差RMSE分别为0.34K和0.65K。敏感性分析表明,在中等湿润的大气条件下,算法对大气水汽含量并不敏感。该算法降低了传感器观测角度带来的地表温度反演误差。利用2009年6月美国SURFRAD辐射观测网6个站点的实测数据对改进算法、原算法以及MOD11_L2地表温度产品进行了对比验证,RMSE分别是0.93K、1.49K和1.0K,表明本文算法可以提高反演精度。 | Ri Changin 柳钦火 历华 方莉 YU Yunyue SUN Donglian | 2013 | 遥感学报2013，17，4： | 8 |
| 20 | 医学模型分类及世界研发商显示文摘医学模型架起医学理论通往临床实践的桥梁。基础解剖示教模型、局部功能性模型、计算机互动模型、虚拟培训系统、生理驱动模拟系统,这五部分各自具有不同功能,在医学生培养中缺一不可。生理驱动模拟系统再造“真实临床环境”,帮助医学生最终实现临床梦想。 | Academy and marketing Department of Rizheng Huarui Enterprise LuSun Wyatt(Ri Zheng Hua Rui) China Co.,Ltd., No.9, Fangzhuang Nanlu, Fengtai District, Beijing, 100079, PRC | 2007 | 中国医院2007，11，4： | 7 |
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