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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | Insertion/deletion polymorphism in the promoter of NFKB1 as a potential molecular marker for the risk of recurrence in superficial bladder cancer显示文摘 | Riemann K Becker L Struwe H | 2007 | Int J Clin Pharmacol Ther2007，45，8： | 1 |
| 3 | Pancreatic cancer--EUS and early diagnosis显示文摘 | Helmstaedter L Riemann JF | 2008 | Langenbecks Arch Surg2008，393，6： | 1 |
| 4 | No association of the NFKB1 insertion/deletion promoter polymorphism with survival in color- ectal and renal cell carcinoma as well as disease progression in B -cell chronic lymphocytic leukemia 显示文摘 | Riemann K Becker L Struwe H | 2006 | Pharmacogenet Ge- nomics2006，16，11： | 1 |
| 5 | Variations in bacterial community structure during a dinoflagellate bloom analyzed by DGGE and 16S rDNA sequencing显示文摘 | Fandino L B Riemann L Steward G F | 2001 | Aquatic Microbial Ecology2001，23，2： | 1 |
| 6 | Pyrose- quencing reveals contrasting seasonal dynamics of taxa within Baltic Sea bacterioplankton communities 显示文摘 | ANDERSON A F RIEMANN L BERTILSSON S | 2009 | The ISME Jour- nal2009，4，2： | 1 |
| 7 | Community dynamics of free- living and particle-associated bacterial assemblages during a freshwater phytoplankton bloom显示文摘 | Riemann L Wingding A | 2001 | Microbial Ecology2001，42，3： | 1 |
| 8 | The genetics of insomnia-Evidence for epigenetic mechanisms?显示文摘 | Palagini L Biber K Riemann D | 2014 | Sleep Med Rev2014，18，： | 1 |
| 9 | Viral lysis of marine bacterioplankton : implications for organic matter cycling and bacterial clonal composition显示文摘 | Riemann L and Middelboe M | 2002 | Ophelia2002，56，： | 1 |
| 10 | The treatments of chronic insomnia: a review of benzodiazepine receptor agonists and psychological and behavioral therapies显示文摘 | Riemann D Perlis M L | 2009 | Sleep Med Rev2009，13，3： | 1 |
| 11 | Pancreatic cancer-EUS and early diagnosis显示文摘 | Helmstaedter L Riemann JF | 2008 | Langenbecks Arch Surg2008，393，6： | 1 |
| 12 | Viral lysis of marine bacterioplankton: implications for organic matter cycling and bacterial elonal composition 显示文摘 | Riemann L Middetboe M | 2002 | Ophelia2002，56，： | 1 |
| 13 | Bacteriophages drive strain diversification in a marine Flavobacterium: implications for phage resistance and physiological properties 显示文摘 | Middelboe M Holmfeldt K Riemann L | 2009 | Environ Microbiol2009，11，8： | 1 |
| 14 | Bacterial community composition during two consecutive NE Monsoon periods in the Arabian Sea studied by denaturing gradient gel electrophoresis(DGGE) of rRNA genes显示文摘 | Riemann L | 1999 | Deep Sea Research PartⅡ:Topical Studies in Oceanography1999，46，89： | 1 |
| 15 | Pyroseque-ncing reveals contrasting seasonal dynamics of taxa within Baltic Sea bacterioplankton communities显示文摘 | Andersson A F Riemann L Bertilsson S | | 0，，： | 1 |
| 16 | Sex comparison of extensibility,passive,and active stiffness of the knee flexors显示文摘 | BLACKBURN J T RIEMANN B L PADUA D A | | 0，，01： | 1 |
| 17 | Virus production and lysate recycling in different sub-basins of the Northern Baltic Sea 显示文摘 | Holmfeldt K Titelman J Riemann L | 2010 | Microbial Ecology2010，60，3： | 1 |
| 18 | Global patterns of diversity and community structure in marine bacterioplankton 显示文摘 | Pommier T Canback B Riemann L | 2007 | Molecular Ecology2007，16，4： | 1 |
| 19 | The sensorimotor system, part I: the physiologic basis of functional joint stability 显示文摘 | RIEMANN B L LEPHART S M | 2002 | Journal of athletic train- ing2002，37，1： | 1 |
| 20 | Pancreatic cancer-EUS and early diagnosis显示文摘 | Helmstaedter L Riemann JF | 2008 | Langenbecks Arch Surg2008，393，6： | 1 |
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