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| 1 | LA-ICPMS原位微区面扫描分析技术及其矿床学应用实例显示文摘LA-ICPMS原位微区面扫描技术的发展对解析具有包裹体、环带结构的矿物或受多期岩浆/热液活动影响形成的溶蚀再结晶的矿物具有重要的地质意义。黄铁矿作为最普遍的硫化物种类之一,可形成于各种类型矿床中,其微量元素组份记录了矿床形成过程的重要信息。通过LA-ICPMS原位微区面扫描技术获得的黄铁矿晶体内部结构组份信息可用来限定成矿流体的性质、厘定成矿流体的演化规律、示踪成矿物质来源、约束变形变质作用过程中元素的活化和迁移行为,以及约束矿床成因等。本次研究选取了内蒙古二连盆地中巴彦乌拉大型铀矿床、辽宁青城子地区榛子沟铅锌矿、加拿大Pardo砂金矿中的黄铁矿作为研究对象,运用原位微区LA-ICPMS元素面扫描技术揭示其内部组份及结构信息,探索该技术在不同类型矿床中的应用价值。巴彦乌拉大型砂岩型铀矿床中的黄铁矿的内部组构信息显示成矿体系的p H和Eh对硫酸盐还原细菌活动均有影响,并控制与之相关的铀矿化;且成矿体系的p H和Eh受到外界不断供给的地下水的影响,呈振荡性变化。辽宁榛子沟铅锌矿中的黄铁矿的内部组构信息显示矿化过程受到了至少两期流体活动的叠加影响,包括早期同沉积时期的流体以及晚期与燕山期岩浆活动有关的热液流体。加拿大Pardo金矿中黄铁矿的内部组构信息显示矿床中半自形-自形的黄铁矿实际包含碎屑成因的磨圆状核部及后期热液活动形成的增生边;金主要呈浸染状分布在碎屑成因的黄铁矿核部,后期热液活动对金矿化影响微弱。 | 周伶俐 曾庆栋 孙国涛 段晓侠 BONNETTI Christophe RIEGLER Thomas LONG Darrel GF KAMBER Balz | 2019 | 岩石学报2019，35，7： | 13 |
| 2 | Transcranial Doppler ultrasonography: From methodology to major clinical applications显示文摘Non-invasive Doppler ultrasonographic study of cerebral arteries [transcranial Doppler(TCD)] has been extensively applied on both outpatient and inpatient settings. It is performed placing a low-frequency(≤ 2 MHz) transducer on the scalp of the patient over specific acoustic windows, in order to visualize the intracranial arterial vessels and to evaluate the cerebral blood flow velocity and its alteration in many different conditions. Nowadays the most widespread indication for TCD in outpatient setting is the research of right to left shunting, responsable of so called 'paradoxical embolism', most often due to patency of foramen ovale which is responsable of the majority of cryptogenic strokes occuring in patients younger than 55 years old. TCD also allows to classify the grade of severity of such shunts using the so called 'microembolic signal grading score'. In addition TCD has found many useful applications in neurocritical care practice. It is useful on both adults and children for day-to-day bedside assessment of critical conditions including vasospasm in subarachnoidal haemorrhage(caused by aneurysm rupture or traumatic injury), traumatic brain injury, brain stem death. It is used also to evaluate cerebral hemodynamic changes after stroke. It also allows to investigate cerebral pressure autoregulation and for the clinical evaluation of cerebral autoregulatory reserve. | Antonello D'Andrea Marianna Conte Massimo Cavallaro Raffaella Scarafile Lucia Riegler Rosangela Cocchia Enrica Pezzullo Andreina Carbone Francesco Natale Giuseppe Santoro Pio Caso Maria Giovanna Russo Eduardo Bossone Raffaele Calabrò | 2016 | World Journal of Cardiology2016，8，7： | 10 |
| 3 | Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 min of hepatic ischemia in a rat model显示文摘AIM: To compare different preconditioning strategies to protect the liver from ischemia/reperfusion injury focusing on the expression of pro- and anti-apoptotic proteins. Interventions comprised different modes of ischemic preconditioning (IP) as well as pharmacologic pretreatment by α-lipoic acid (LA). METHODS: Several groups of rats were compared: sham operated animals, non-pretreated animals (nt), animals receiving IP (10 min of ischemia by clamping of the portal triad and 10 min of reperfusion) prior to sustained ischemia, animals receiving selective ischemic preconditioning (IPsel, 10 min of ischemia by selective clamping of the ischemic lobe and 10 min of reperfusion) prior to sustained ichemia, and animals receiving 500 μmol α-LA injected i.v. 15 min prior to the induction of 90 min of selective ischemia. RESULTS: Cellular damage was decreased only in the LA group. TUNEL-positive hepatocytes as well as necrotic hepatocyte injury were also decreased only by LA (19 ± 2 vs 10 ± 1, P < 0.05 and 29 ± 5 vs 12 ± 1, P < 0.05). Whereas caspase 3- activities in liver tissue were unchanged, caspase 9- activity in liver tissue was decreased only by LA pretreatment (3.1 ± 0.3 vs 1.8 ± 0.2, P < 0.05). Survival rate as the endpoint of liver function was increased after IP and LA pretreatment but not after IPsel. Levels of lipid peroxidation (LPO) in liver tissue were decreased in the IP as well as in the LA group compared to the nt group. Determination of pro- and anti-apoptotic proteins showed a shift towardsanti-apoptotic proteins by LA. In contrast, both our IP strategies failed to influence apototic cell death. CONCLUSION: IP, consisting of 10 min of ischemia and 10 min of reperfusion, protects only partly against ischemia/reperfusion injury of the liver prior to 90 min of selective ischemia. IPsel did not influence ischemic tolerance of the liver. LA improved tolerance to ischemia, possibly by downregulation of pro-apoptotic Bax. | Friedrich Duenschede Kirsten Erbes Nina Riegler Patrick Ewald Achim Kircher Stefanie Westermann Arno Schad Imke Miesmer Simon Albrecht-Schck Ines Gockel Alexandra K Kiemer Theodor Junginger | 2007 | World Journal of Gastroenterology2007，13，27： | 8 |
| 4 | Adipose tissue and vascular inflammation in coronary artery disease显示文摘Obesity has become an important public health issue in Western and developing countries,with well known metabolic and cardiovascular complications.In the last decades,evidence have been growing about the active role of adipose tissue as an endocrine organ in determining these pathological consequences.As a consequence of the expansion of fat depots,in obese subjects,adipose tissue cells develope a phenotypic modification,which turns into a change of the secretory output.Adipocytokines produced by both adipocytes and adipose stromal cells are involved in the modulation of glucose and lipid handling,vascular biology and,moreover,participate to the systemic inflammatory response,which characterizes obesity and metabolic syndrome.This might represent an important pathophysiological link with atherosclerotic complications and cardiovascular events.A great number of adipocytokines have been described recently,linking inflammatory mileu and vascular pathology.The understanding of these pathways is crucial not only from a pathophysiological point of view,but also to a better cardiovascular disease risk stratification and to the identification of possible therapeutic targets.The aim of this paper is to review the role of Adipocytokines as a possible link between obesity and vascular disease. | Enrica Golia Giuseppe Limongelli Francesco Natale Fabio Fimiani Valeria Maddaloni Pina Elvira Russo Lucia Riegler Renatomaria Bianchi Mario Crisci Gaetano Di Palma Paolo Golino Maria Giovanna Russo Raffaele Calabrò Paolo Calabrò | 2014 | World Journal of Cardiology2014，6，7： | 8 |
| 5 | Breath test for differential diagnosis between small intestinal bacterial overgrowth and irritable bowel disease:An observation on non-absorbable antibiotics显示文摘AIM: To estimate the prevalence of small intestine bacterial overgrowth (SIBO) among patients with an earlier diagnosis of irritable bowel disease (IBS) in our geographical area, and to collect information on the use of locally acting non-absorbable antibiotics in the management of SIBO. METHODS: A non-interventional study was conducted in 73 consecutive patients with a symptom-based diagnosis.. RESULTS: When the patients underwent a 'breath test', 33 (45.2%) showed the presence of a SIBO. After treatment with rifaximin 1200 mg/d for seven days in 32 patients, 19 (59.4%) showed a negative 'breath test' one week later as well as a significant reduction of symptoms, thus confirming the relationship between SIBO and many of the symptoms claimed by patients. In the other 13 patients, 'breath test' remained positive, and a further cycle of treatment with ciprofloxacin 500 mg/d was given for 7 additional days, resulting in a negative 'breath test' in one patient only. CONCLUSION: (1) about half of the patients with a symptomatic diagnosis of IBS have actually SIBO, which is responsible for most of the symptoms attributed to IBS; (2) only a 'breath test' with lactulose (or with glucose in subjects with an intolerance to lactose) can provide a differential diagnosis between IBS and SIBO, with almost identical symptoms; and (3) the use of non-absorbable antibiotics may be useful to reduce the degree of SIBO and related symptoms; it must be accompanied, however, by the correction of the wrong alimentary habits underlying SIBO. | I Esposito A de Leone G Di Gregorio S Giaquinto L de Magistris A Ferrieri G Riegler | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 6 | Methodology to develop machine learning algorithms to improve performance in gastrointestinal endoscopy显示文摘Assisted diagnosis using artificial intelligence has been a holy grail in medical research for many years, and recent developments in computer hardware have enabled the narrower area of machine learning to equip clinicians with potentially useful tools for computer assisted diagnosis(CAD) systems. However, training and assessing a computer's ability to diagnose like a human are complex tasks, and successful outcomes depend on various factors. We have focused our work on gastrointestinal(GI) endoscopy because it is a cornerstone for diagnosis and treatment of diseases of the GI tract. About 2.8 million luminal GI(esophageal, stomach, colorectal) cancers are detected globally every year, and although substantial technical improvements in endoscopes have been made over the last 10-15 years, a major limitation of endoscopic examinations remains operator variation. This translates into a substantial inter-observer variation in the detection and assessment of mucosal lesions, causing among other things an average polyp miss-rate of 20% in the colon and thus the subsequent development of a number of post-colonoscopy colorectal cancers. CAD systems might eliminate this variation and lead to more accurate diagnoses. In this editorial, we point out some of the current challenges in the development of efficient computer-based digital assistants. We give examples of proposed tools using various techniques, identify current challenges, and give suggestions for the development and assessment of future CAD systems. | Thomas de Lange Pal Halvorsen Michael Riegler | 2018 | World Journal of Gastroenterology2018，24，45： | 6 |
| 7 | Gastroesophageal reflux disease management according to contemporary international guidelines:A translational study显示文摘AIM:To test the Genval recommendations and the usefulness of a short trial of proton pump inhibitor(PPI) in the initial management and maintenance treatment of gastroesophageal reflux disease(GERD)patients. METHODS:Five hundred and seventy seven patients with heartburn were recruited.After completing a psychometric tool to assess quality of life(PGWBI)and a previously validated GERD symptom questionnaire (QUID),patients were grouped into those with esophagitis(EE,n=306)or without mucosal damage (NERD,n=271)according to endoscopy results. The study started with a 2-wk period of high dose omeprazole(omeprazole test);patients responding to this PPI test entered an acute phase(3 mo)of treatment with any PPI at the standard dose.Finally,those patients with a favorable response to the standard PPI dose were maintained on a half PPI dose for a further 3-mo period. RESULTS:The test was positive in 519(89.9%)patients,with a greater response in EE patients(96.4%) compared with NERD patients(82.6%)(P=0.011). Both the percentage of completely asymptomatic patients,at 3 and 6 mo,and the reduction in heartburn intensity were significantly higher in the EE compared with NERD patients(P<0.01).Finally,the mean PGWBI score was significantly decreased before and increased after therapy in both subgroups when compared with the mean value in a reference Italian population. CONCLUSION:Our study confirms the validity of the Genval guidelines in the management of GERD patients. In addition,we observed that the overall response to PPI therapy is lower in NERD compared to EE patients. | Fabio Pace Gabriele Riegler Annalisa de Leone Patrizia Dominici Enzo Grossi the EMERGE Study Group | 2011 | World Journal of Gastroenterology2011，17，9： | 5 |
| 8 | Bristol scale stool form. A still valid help in medical practice and clinical research显示文摘 | G. Riegler I. Esposito | 2001 | Techniques in Coloproctology2001，，3： | 3 |
| 9 | Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult-and pediatric-onset inflammatory bowel disease in Italy显示文摘AIM: To investigate gene variants in a large Italian inflammatory bowel disease (IBD) cohort, and to analyze the correlation of sub-phenotypes (including age at diagnosis) and epistatic interaction with other IBD genes. METHODS: Total of 763 patients with Crohn's disease (CD, 189 diagnosed at age < 19 years), 843 with ulcerative colitis (UC, 179 diagnosed <19 years), 749 healthy controls, and 546 healthy parents (273 trios) were included in the study. The rs2241880 [autophagy-related 16-like 1 (ATG16L1)], rs11209026 and rs7517847 [interleukin 23 receptor (IL23R)], rs2066844, rs2066845, rs2066847 (CARD15), rs1050152 (OCTN1), and rs2631367 (OCTN2) gene variants were genotyped. RESULTS: The frequency of G allele of ATG16L1 SNP (Ala197Thr) was increased in patients with CD compared with controls (59% vs 54% respectively) (OR = 1.25, CI = 1.08-1.45, P = 0.003), but not in UC (55%). The frequency of A and G (minor) alleles of Arg381Gln, rs11209026 and rs7517847 variants of IL23R were reduced significantly in CD (4%, OR = 0.62, CI = 0.45-0.87, P = 0.005; 28%, OR = 0.64, CI = 0.55-0.75, P < 0.01), compared with controls (6% and 38%, respectively). The A allele (but not G) was also reduced signifi cantly in UC (4%, OR = 0.69, CI = 0.5-0.94, P = 0.019). No association was demonstrated with sub-phenotypes and interaction with CARD15 , and OCTN1/2 genes, although both gene variants were associated with pediatric-onset disease. CONCLUSION: The present study confirms the association of IL23R polymorphisms with IBD, and ATG16L1 with CD, in both adult- and pediatric-onset subsets in our study population. | Anna Latiano Orazio Palmieri Maria Rosa Valvano Renata D'Incà Salvatore Cucchiara Gabriele Riegler Anna Maria Staiano Sandro Ardizzone Salvatore Accomando Gian Luigi de Angelis Giuseppe Corritore Fabrizio Bossa Vito Annese | 2008 | World Journal of Gastroenterology2008，14，29： | 3 |
| 10 | Cardiac damage in athlete's heart: When the “supernormal” heart fails!显示文摘Intense exercise may cause heart remodeling to compensate increases in blood pressure or volume by increasing muscle mass. Cardiac changes do not involve only the left ventricle, but all heart chambers. Physiological cardiac modeling in athletes is associated with normal or enhanced cardiac function, but recent studies have documented decrements in left ventricular function during intense exercise and the release of cardiac markers of necrosis in athlete's blood of uncertain significance. Furthermore, cardiac remodeling may predispose athletes to heart disease and result in electrical remodeling, responsible for arrhythmias. Athlete's heart is a physiological condition and does not require a specific treatment. In some conditions, it is important to differentiate the physiological adaptations from pathological conditions, such as hypertrophic cardiomyopathy, arrhythmogenic dysplasia of the right ventricle, and non-compaction myocardium, for the greater risk of sudden cardiac death of these conditions. Moreover, some drugs and performance-enhancing drugs can cause structural alterations and arrhythmias, therefore, their use should be excluded. | Andreina Carbone Antonello D’Andrea Lucia Riegler Raffaella Scarafile Enrica Pezzullo Francesca Martone Raffaella America Biagio Liccardo Maurizio Galderisi Eduardo Bossone Raffaele Calabrò | 2017 | World Journal of Cardiology2017，9，6： | 3 |
| 11 | The course of inflammatory bowel disease during pregnancy and postpartum: a prospective European ECCO‐EpiCom Study of 209 pregnant women显示文摘 | N. Pedersen A. Bortoli D. Duricova R. D′Inca M. R. Panelli J. P. Gisbert G. Zoli A. López‐Sanromán F. Castiglione G. Riegler V. Annese P. Gionchetti A. Prada E. D. Pont A. Timmer C. Felley M. Shuhaibar E. V. Tsianos C. Dejaco F. J. Baert T. Jess M. Lebech | 2013 | Aliment Pharmacol Ther2013，，5： | 2 |
| 12 | Enzymes in- volved in hepatic acylglycerol metabolism in the chicken显示文摘 | Riegler B Besenboeck C Bauer R | 2011 | Biochemical and Biophysical Research Communications2011，406，： | 1 |
| 13 | Effects and side-effects of 2% progesterone cream on the skin of peri-and postmenopausal women显示文摘 | Hoizer G Riegler E Honigsmann H | 2005 | Br J Dermatol2005，153，3： | 1 |
| 14 | Extended theorems for signal induction in particle detectors VCI 2004显示文摘 | Riegler W | 2004 | Nuclear Instruments and Methods in Physics Research A2004，535，： | 1 |
| 15 | Trends and highlights of VCI 2004显示文摘 | Fabian C W Riegler W | 2004 | Nuclear Instruments and Methods in Physics Research A2004，535，： | 1 |
| 16 | Picosecond absorption and fluorescence studies on large phytochrome from rye显示文摘 | Riegler H Aussenegg F R | 1988 | Biochem Physiol Pflanz1988，183，： | 1 |
| 17 | Clostr/dium difficile toxin B is more potent than toxin A in damaging human colonic epitheli- um in vitro显示文摘 | Riegler M Sedivy R Pothoulakis C | 1995 | J Clin Invest1995，95，5： | 1 |
| 18 | Epidermal growth factor promotes rapid response to epithelial injury in rabbit duodenum in vitro显示文摘 | Riegler M Sedivy R Sogukoglu T | 1996 | Gastroenterology1996，111，： | 1 |
| 19 | Clostridium difficile toxin B is more potent than toxin A in damaging human colonic epithelium in vitro显示文摘 | Riegler MR Sedivy R Pothoulakis C | 1995 | J Clin Invest1995，95，5： | 1 |
| 20 | In defense of the nerve stimulator 显示文摘 | Riegler FX | 1998 | Reg Anesth Pain Med1998，23，： | 1 |
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