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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 3 | Inhalation of the phosphodiesterase-3 inhibitor milrinone attenuates pulmonary hypertension in a rat model of congestive heart failure 显示文摘 | HENTSCHEL T YIN N RIAD A | 2007 | Anesthesiology2007，106，1： | 1 |
| 4 | Cavitation corrosion behavoior of cast nickel-aluminum bronze in seawater显示文摘 | Hashem A Caceres P G Riad W T | 1995 | Corrosion1995，51，5： | 1 |
| 5 | Inhalation of the phosphodies-terase-3 inhibitor milrinone attenuates pulmonary hypertension ina rat model of congestive heart failure显示文摘 | Hentschel T Yin N Riad A | 2007 | Anesthesiology2007，106，1： | 1 |
| 6 | Awwad, Mucous Membrane Graft Versus Gunderson conjunctival flap for fitting a scleral shell ober a sensitive cornea 显示文摘 | RIAD N MA LUF MD SHADY T | 2005 | Ophthal Plast Reconstr Surg2005，21，5： | 1 |
| 7 | Cavitation corrosion behavior of cast Ni-AI bronze in seawater 显示文摘 | Hashem A Caceres P G Riad W T | 1995 | Corrosion1995，51，5： | 1 |
| 8 | New direct torque neuro-fuzzy control based SVM-three level inverter- fed induction motor 显示文摘 | RIAD T HOCINE B SALIMA M | 2010 | Control Automation and Systems2010，8，5： | 1 |
| 9 | Inhalation of the phosphodiesterase-3 inhibitor milrinone attenuates pulmonary hypertension in a rat model of congestive heart failure 显示文摘 | Hentsehel T Yin N Riad A | 2007 | Anesthesiology2007，106，1： | 1 |
| 10 | Cavitation corrosion behavior of cast nickel-aluminum bronze inseawater 显示文摘 | AL-HASHEM A CACERES P G RIAD W T SHALABY H M | 1995 | Corrosion1995，51，5： | 1 |
| 11 | Cavitation cor- rosion behavior of cast nickel-aluminum bronze in seawa- ter 显示文摘 | A1-Hashem A Caceres P G Riad W T | 1995 | Corrosion1995，51，5： | 1 |
| 12 | Cavitation corrosion behavoior of cast nickel-aluminum bronze in sea-water显示文摘 | Hashem A Caceres P G Riad W T | 1995 | Corrosion1995，51，5： | 1 |
| 13 | Inhalation of the phosphodiesterase- 3 inhibitor milrinone attenuates pulmonary hypertension in a rat model of congestive heart failure显示文摘 | HENTSCHEL T YIN N RIAD A | 2007 | Anesthesiology2007，106，1： | 1 |
| 14 | Cavitation corrosion behavior of cast nickel-aluminum bronze in seawater显示文摘 | HASHEM A CACERES P G RIAD W T | 1995 | Corrosion1995，51，5： | 1 |
| 15 | Cavitation corrosion behavior of cast nickel-aluminum Bronze in seawater 显示文摘 | Hashem A Caceres P G Riad W T | 1995 | Corrosion1995，51，5： | 1 |
| 16 | Impact of glacycosylation on effector functions of thepeutic IgG显示文摘 | Riad A Jean-Luc T | 2010 | Pharmaceuticals2010，3，： | 1 |
| 17 | The role of microstructure of nickel-aluminium-bronze alloy on its cavitation corrosion behavior in natural seawater 显示文摘 | Al-Hashem A Riad W T | 2002 | Materials Characterization2002，48，： | 1 |
| 18 | Inhalation of the phosphodiesterase - 3 inhibitor milrinone attenuates pulmonary hypertension in a rat model of congestive heart failure显示文摘 | Hentsehel T Yin N Riad A | 2007 | Anesthesiology2007，106，1： | 1 |
| 19 | Impact of glacycosylation on effector functions of thepeutic IgG显示文摘 | Riad A Jean-Luc T | 2010 | Pharmaceuticals2010，3，： | 1 |
| 20 | Cavitation corrosion behavior of cast nickel - aluminum bronze in seawater 显示文摘 | Caceres P G Riad W T | 1995 | Corrosion1995，51，5： | 1 |
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