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| 1 | Early treadmill exercise increases macrophage migration inhibitory factor expression after cerebral ischemia/reperfusion显示文摘The neuroprotective function of macrophage migration inhibitory factor(MIF) in ischemic stroke was rarely evaluated.This study aimed to investigate the effects of early treadmill exercise on recovery from ischemic stroke and to determine whether these effects are associated with the expression levels of MIF and brain-derived neurotrophic factor(BDNF) in the ischemic area.A total of 40 male Sprague-Dawley rats were randomly assigned to the ischemia and exercise group [middle cerebral artery occlusion(MCAO)-Ex,n = 10),ischemia and sedentary group(MCAO-St,n = 10),sham-surgery and exercise group(Sham-Ex,n= 10),or sham-surgery and sedentary group(Sham-St,n = 10).The MCAO-Ex and MCAO-St groups were subjected to MCAO for 60 minutes,whereas the Sham-Ex and Sham-St groups were subjected to an identical operation without MCAO.Rats in the MCAO-Ex and Sham-Ex groups then ran on a treadmill for 30 minutes once a day for 5 consecutive days.After reperfusion,the hanging time tested by the wire hang test was longer and the relative fractional anisotropy determined by MRI was higher in the peri-infarct region of the MCAO-Ex group compared with the MCAO-St group.The expression levels of MIF and BDNF in the peri-infarct region were upregulated in the MCAO-Ex group.Increased MIF and BDNF levels were positively correlated with relative fractional anisotropy changes in the peri-infarct region.There was no significant difference in the levels of MIF and BDNF in the peri-infarct region between the Sham-Ex and Sham-St groups.Our study demonstrated that early exercise(initiated 48 hours after the MCAO) could improve motor and neuronal recovery after ischemic stroke.Furthermore,the increased levels of MIF and BDNF in the peri-infarct region(penumbra) may be one of the mechanisms of enhanced neurological function recovery.All experiments were approved by the Institutional Animal Care and Use Committee in Asan Medical Center in South Korea(2016-12-126). | Min Cheol Chang Chae Ri Park Seung Hwa Rhie Woo Hyun Shim Dae Yul Kim | 2019 | Neural Regeneration Research2019，14，7： | 7 |
| 2 | Two flaps andZ-plasty technique for correction of longitudinal era lobe cleft显示文摘 | JU H S RHIE J W | 2005 | Br J Plast Surg2005，58，4： | 1 |
| 3 | Carmustine induces ERK-and JNK-dependent cell death of neuronally-differentiated PC12 cells via generation of reactive oxygen species 显示文摘 | An JM Kim SS Rhie JH | 2011 | Toxieol In Vitro2011，25，7： | 1 |
| 4 | Serum kisspeptin levels in Korean girls with central precocious puberty 显示文摘 | Rhie YJ Lee KH Eun SH | 2011 | Kore- an Sci2011，26，7： | 1 |
| 5 | Utilization of wood biomass char in a direct carbon fu el cell (DCFC) system显示文摘 | Seong Yool Ahn Seong Yong Eom Young Hoon Rhie | 2013 | Applied Energy2013，105，： | 1 |
| 6 | A numerical study of the turbulent flow past an isolated airfoil with trailing edge separation 显示文摘 | Rhie C M Chow W L | | AIAA82-09980，，： | 1 |
| 7 | Numerical study of the turbulent flow past an airfoil with trailing edge separation 显示文摘 | RHIE C M CHOW W L | 1983 | AIAA Journal1983，21，11： | 1 |
| 8 | Numerical study of the turbulent flow past an airfoil with trailing edge separation显示文摘 | RHIE C M CHOW W L | | 0，，11： | 1 |
| 9 | Association of ser- um retinol binding protein 4 with adiposity and pu- bertal development in korean children and adoles- cents显示文摘 | Rhie Y J Choi BM Eun SH | 2011 | J Korean Med Sci2011，26，6： | 1 |
| 10 | Numerical study of the turbu- lent flow past an isolated airfoil with trailing edge sep- aration显示文摘 | Rhie C M Chow W L | 1983 | AIAA1983，21，11： | 1 |
| 11 | Chilling requirement for breaking dormancy and flowering in Paeonia lactiflora ' Tae- baek'and 'Mulsurae' 显示文摘 | RHIE Y H JUNG H H KIM K S | 2012 | Horticulture Environment and Biotechnology2012，53，4： | 1 |
| 12 | C lin ica 1 lea tures and trea tm ent ofM a lassezia fo lliculitis with fluconazo le in orthotopic heart transplant rec ip ients 显示文摘 | Rhie S Ture ios R Buck ley H | 2010 | J Heart Lung T ransplant2010，19，： | 1 |
| 13 | Development application of a multistage Navier-Stokes solver: part I Multistage modeling using body forces and deterministic stresses 显示文摘 | Rhie C M Glexner A J Spear D A | 1998 | ASME Journal of Turbomachinery1998，120，2： | 1 |
| 14 | Development and Application of a Multi - Stage Navier - Stokes Solver: Part I - Multistage Modeling Using Body Forces and Deterministic Stresses显示文摘 | Rhie C M Gleixner A J Spear D | 1998 | ASME Journal of Turbomachinery1998，120，2： | 1 |
| 15 | Numerical study of the turbulent flow past an airfoil with trailing edge separation显示文摘 | Rhie C M Chow W L | 1983 | AIAA Journal1983，21，11： | 1 |
| 16 | Magnetic-field-controlled reconfigurable semiconductor logic 显示文摘 | JOO S KIM T SHIN S H LIM J Y HONG J SONG J D CHANG J LEE H W RHIE K HAN S H SHIN K H JOHNSON M | 2013 | Nature2013，494，： | 1 |
| 17 | Somatostatin potentiates voltage-dependent K+ and Ca2+ channel expression induced by nerve growth factor in PC12 cells显示文摘 | Rhie DJ Yi SY Hahn SJ | 1999 | Brain Res Dev Brain Res1999，112，： | 1 |
| 18 | A numerical study of the turbulent flow past an isolated airfoil with trailing edge separation显示文摘 | Rhie C M Chow W L | 1983 | AIAA J1983，21，： | 1 |
| 19 | A Numerical Study of the Turbulent Flow Past an Isolated Airfoil with Trailing Edge Separation显示文摘 | Rhie C M Chow W L | 1983 | Journal of AIAA1983，21，11： | 1 |
| 20 | A numerical study of the turbulent flow past an isolated airfoil with trailing edgeseparation显示文摘 | RHIE C M CHOW W L | 1983 | AIAA Journal1983，21，： | 1 |
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