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| 1 | 中国成年人代谢综合征的患病率显示文摘目的本研究旨在提供关于我国35~74岁一般成年人群代谢综合征(MS)及其主要组成成分患病率的最新资料。方法我们于2000~2001年在全国35~74岁的成年人群中代表性地选择了15540例个体进行横断面调查。根据国际糖尿病联盟2004年度推荐的有关中国人MS的标准诊断MS和进行组分分类。结果男女合计,年龄未标化的MS患病率为16.5%。年龄标化后的MS患病率,男女分别为10.0%和23.3%;年龄标化后的患病率,北方和南方地区分别为23.3%和11.5%,城市和农村地区分别为23.5%和14.7%。我国北方居民的MS患病率高于南方居民,城市居民高于农村居民。结论我国成年人中有相当比例的个体患有MS。这些结果提示我国亟需制定面向全国的预防、检测和治疗MS的卫生策略,以降低心血管疾病的社会负担。 | 顾东风 Reynolds K 杨文杰 陈恕凤 吴锡桂 段秀芳 蒲晓东 徐丽华 吴先萍 陈祥福 魏仁敏 陈娜萦 吴天一 王礼桂 姚才良 牟建军 马义峰 王晓飞 Whelton P 何江 | 2005 | 中华糖尿病杂志(1006-6187)2005，13，3： | 579 |
| 2 | 抗精神病药物致体重增加与5羟色胺2C受体基因启动子区多态性的关系显示文摘目的 探讨首发精神分裂症患者抗精神病药物 (APS)治疗过程中的体重增加与 5羟色胺 2C受体 (HTR2C)基因启动区 - 759C/T单核酸置换多态性有无相关。方法 采用PCR RFLP技术分析 1 1 7例首发精神分裂症患者 (男 58例 ,女 59例 )HTR2C基因 - 759C/T半合子 (男性 )或基因型 (女性 )分布频率 ,APS(利培酮或氯丙嗪 )单药治疗 1 0周 ,测定患者治疗前后的体重和体重指数 (BMI) ,并分析半合子或基因型与BMI变化值的相关性。结果 治疗后患者平均体重增加 (3 2± 3 5)kg或基础体重的 (5 7± 6 2 ) % ,体重变化范围为 - 7kg~ 1 2kg或 - 7 8%~ 32 %。 58例男性患者突变型半合子频率为 1 9% ,59例女性患者突变型纯合子频率为 0 % ,杂合子频率为 2 7 0 %。 - 759T半合子 (男性 )或杂合子 (女性 )在体重增加 >7%和体重增加 <7%的患者组分布差异有非常显著意义 (χ2 =2 2 35 ,P=0 0 0 0 1 ;χ2 =1 2 36 ,P =0 0 0 0 1 ) ;与携带 - 759T半合子或杂合子患者组相比 ,不携带者体重增加的危险度高 5~ 6倍 (OR =5 1 1 ,6 68)。结论 HTR2C基因启动区 - 759C/T单核酸置换多态性与APS治疗导致汉族精神分裂症患者体重增加相关联 ,而 - 759C→T单核酸置换是防止和限制体重增加的基因保护因素。 | 张志珺 张晓斌 姚志剑 孙静 姚辉 侯钢 张心保 陈建芳 Gavin P Reynolds | 2002 | 中华医学杂志2002，82，16： | 23 |
| 3 | 接受治疗的老年高血压患者的血压、抗高血压药物应用、衰弱指标与严重摔伤风险的关系显示文摘一些研究表明,降压药物、低收缩压和舒张压与跌倒风险增加相关。许多老年人表现出衰弱的指征,这可能会增加跌倒的风险。该研究纳入脑卒中地区和种族差异原因(the reasons for geographic and racial differences in stroke,REGARDS)研究中年龄≥65岁的受试者5236例,探索收缩压、舒张压、抗高血压药物类别数量以及衰弱指标与严重跌倒损伤风险的关系, | 刘莉 叶鹏 Bromfield SG Ngameni CA Colantonio LD Bowling CB Shimbo D Reynolds K Safford MM Banach M Toth PP Muntner P | 2017 | 中华高血压杂志2017，25，8： | 19 |
| 4 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 5 | Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis显示文摘 | V Arroyo P Gines AL Gerbes FJ Dudley P Gentilini G Laffi TB Reynolds H Ring-Larsen J Scholmerich | 1996 | Hepatology1996，，1： | 3 |
| 6 | Mammary gland growth and vascularity at parturition and during lactation in primiparous ewes fed differing levels of selenium and nutritional plane during gestation显示文摘Background: Objectives were to examine the effects of selenium(Se) supply and maternal nutritional plane during gestation on mammary gland growth, cellular proliferation, and vascularity at parturition and d 20 of lactation. Rambouillet primiparous ewes(n = 84) were allocated to treatments in a 2 x 3 factorial. Factors were dietary Se(adequate Se [ASe, 11.5 μg/kg BW] or high Se [HSe, 77.0 μg/kg BW]) and nutritional plane(60% [RES], 100% [CON], or 140% [EXC]). At parturition, lambs were removed and 42 ewes(7/treatment) were necropsied. Remaining ewes were fed a common diet meeting requirements for lactation and mechanically milked twice daily until necropsy on d 20. At both necropsy periods, mammary glands were dissected and tissues harvested. Samples were analyzed for RNA, DNA, and protein content, cell proliferation, and vascularity. Where interactions were present(P ≤ 0.05), least squares means from the highest-order interaction are presented. Results: Final body weight of ewes was least(P ≤ 0.002) in RES, intermediate for CON, and greatest for EXC, regardless of stage of the ewe at necropsy(parturition or d 20 of lactation). In ewes necropsied at parturition, mammary glands were heavier(P = 0.02) in EXC compared to RES, with CON intermediate. Concentration of RNA(mg/g) was decreased(P = 0.01) in EXC compared to CON at parturition. There was a tendency(P = 0.07) for a Se by nutrition interaction in percentage of cells proliferating where ASe-EXC ewes had greater(P ≤ 0.02) number of proliferating cells then all other treatments. Mammary vascular area tended(P = 0.08) to be affected by a Se by nutrition interaction where ASe-CON had less(P = 0.007) vascular area than HSe-CON ewes. In ewes necropsied at d 20 of lactation, the number of alveoli per area was decreased(P ≤ 0.05) in RES compared to CON and EXC-fed ewes. Conclusions: Results of this study indicate that proper maternal nutritional plane during gestation is important for mammary gland development, even out to d 20 of lactation. | Tammi L Neville Allison M Meyer Arshi Reyaz Pawel B Borowicz Dale A Redmer Lawrence P Reynolds Joel S Caton Kimberly A Vonnahme | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 3 |
| 7 | Trans-gender induction of hair follicles显示文摘 | Reynolds A J Lawronee C Cserhalmi-Friedman P B | 1999 | Nature1999，402，6757： | 2 |
| 8 | Phenotypic instability and rapid gene silencing in newly formed Arabidopsis alloteraploids显示文摘 | Comai L Tyagi A P Winter K Holmes-Davis R Reynolds S H Stevens Y Byers B | 2000 | Plant Cell2000，12，9： | 2 |
| 9 | Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis显示文摘 | V Arroyo P Gines AL Gerbes FJ Dudley P Gentilini G Laffi TB Reynolds H Ring-Larsen J Scholmerich | 1996 | Hepatology1996，，1： | 2 |
| 10 | (2004) Birth haracteristics and hepatoblastoma risk in young children显示文摘 | Umyama KY Von Behren J | 2004 | Cancer2004，，： | 1 |
| 11 | DC insulation analysis:a new and better method 显示文摘 | Reynolds P H Leszczynski S A | 1985 | IEEE Trans on PAS1985，104，7： | 1 |
| 12 | Geographic variations in the prevalence,awareness,treatment and control of hypertension in China显示文摘 | Reynolds K Gu D Muntner P | 2003 | JHypertens2003，21，7： | 1 |
| 13 | Placental angiogenesis in sheep models of compromised pregnancy 显示文摘 | Reynolds L P Borowicz P P Vonnahme K A | 2005 | The Journal of Physiology2005，，： | 1 |
| 14 | On the division of attention: A disproof of the single channel hypothesis显示文摘 | Allport D Antonis B Reynolds P | 1972 | Quarterly Journal of Experimental Psychology1972，24，： | 1 |
| 15 | The prevalence of nascent entrepreneurs in the United States: evidence from the panel study of entrepreneurial dynandler显示文摘 | Reynolds P D N M Carter W B Gartner P G Greene | 2004 | Small Business Economics2004，23，： | 1 |
| 16 | Gut barrier failure in experimental obstructive jaundice显示文摘 | Reynolds JV Murchan P Leonard N et a1 | 1996 | JSurgRes1996，62，1： | 1 |
| 17 | Visualization of the material flow in AA2195 friction-stir welds using a maker insert technology显示文摘 | SEIDEL T U REYNOLDS A P | 2001 | Metall Mater Trans A2001，32，： | 1 |
| 18 | Placental angiogensis in sheep sodels of compromised pregnancy显示文摘 | Reynolds L P Borowicz P P Vonnahme K A | 2005 | The Journal of Physology2005，565，1： | 1 |
| 19 | The availability of physician services: a geographic analysis显示文摘 | Wing P Reynolds C | 1988 | Health Services Research1988，，23： | 1 |
| 20 | Global entrepreneurship monitor: Data collection design and implementation 1998--2003 显示文摘 | Reynolds P D Basma N Autio E | 2005 | Small Business Economics2005，24，3： | 1 |
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