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| 1 | Diabetic neuropathic pain:Physiopathology and treatment显示文摘Diabetic neuropathy is a common complication of both type 1 and type 2 diabetes,which affects over 90% of the diabetic patients.Although pain is one of the main symptoms of diabetic neuropathy,its pathophysiological mechanisms are not yet fully known.It is widely accepted that the toxic effects of hyperglycemia play an important role in the development of this complication,but several other hypotheses have been postulated.The management of diabetic neuropathic pain consists basically in excluding other causes of painful peripheral neuropathy,improving glycemic control as a prophylactic therapy and using medications to alleviate pain.First line drugs for pain relief include anticonvulsants,such as pregabalin and gabapentin and antidepressants,especial y those that act to inhibit the reuptake of serotonin and noradrenaline.In addition,there is experimental and clinical evidence that opioids can be helpful in pain control,mainly if associated with first line drugs.Other agents,including for topical application,such as capsaicin cream and lidocaine patches,have also been proposed to be useful as adjuvants in the control of diabetic neuropathic pain,but the clinical evidence is insufficient to support their use.In conclusion,a better understanding of the mechanisms underlying diabetic neuropathic pain will contribute to the search of new therapies,but also to the improvement of the guidelines to optimize pain control with the drugs currently available. | Anne K Schreiber Carina FM Nones Renata C Reis Juliana G Chichorro Joice M Cunha | 2015 | World Journal of Diabetes2015，6，3： | 34 |
| 2 | Innate antiviral responses by means of TLRT-mediated recognition of single-stranded RNA显示文摘 | Diebold S S Kaisho T Hemmi H Akira S Reis e Sousa C | 2004 | Science2004，303，： | 1 |
| 3 | A rare spontaneous osteosarcoma of the calvarium in a patient with long - standing fibrous dysplasia: CT and MR findings 显示文摘 | Reis C Genden EM Bederson JB | 2008 | Br J Radiol2008，9，62： | 1 |
| 4 | Spatial-temporal patterns in Mediterranean carnivore road casualties:Consequences for mitigation显示文摘 | Grilo C Bissonette JA Reis MS | | 0，，： | 1 |
| 5 | A structured proteomic approach identifies 14-3-3Sigma as a novel and reliable protein biomarker in panel based differential diagnostics of liver tumors 显示文摘 | Reis H Putter C Megger DA | 2015 | Biochim Biophys Acta2015，1854，6： | 1 |
| 6 | Experimental analy- sis of an all-optical packet router显示文摘 | Reis C Parca G Bougioukos M | 2014 | Journal of Optical Communications and Networking2014，6，7： | 1 |
| 7 | Photochemical behavior under UVA radiation of β-cyclodextrin included Parsol 1789 with a chemometric approach 显示文摘 | Biloti D N dos Reis M M Ferreira M M C | 1999 | Journal of Molecular Structure1999，，480481： | 1 |
| 8 | Activation of dendritic cells: translating in nate into adaptive immunity显示文摘 | Reis E Sousa C | 2004 | Curr Opin Immunol2004，16，： | 1 |
| 9 | Innate recognition of viruses 显示文摘 | Pichlmair A Reis e Sousa C | 2007 | Immunity2007，27，3： | 1 |
| 10 | Removal of inorganic charged micro-pollutants in an ion-exchange membrane bioreactor 显示文摘 | Velizarov S Matos C Reis M A M | 2005 | Desalination2005，178，13： | 1 |
| 11 | Prolonged ischemia is associated with more pronounced rejection in the lung allograft显示文摘 | Serrick C Giaid A Reis A | 1997 | Ann Thorac Surg1997，63，1： | 1 |
| 12 | Dexamethasone-loaded scaffolds prepared by supercritical-assisted phase inversion显示文摘 | Duarte A R C Mano J F Reis R L | 2009 | Acta Biomaterialia2009，5，6： | 1 |
| 13 | Chronic idiopathic constipation:a psychological enquiry显示文摘 | Dykes S Smigin2hump reys S Bass C | 2001 | Eur J Gastroenterol H epatol2001，13，： | 1 |
| 14 | Recovery of phenol from aqueous solutions using liquid membranes with cyanex 923显示文摘 | Reis M T A De freitas O M Ismael M R C | 2007 | J Membrane Sci2007，305，1： | 1 |
| 15 | Re -attachment of anterior fractured teeth : fracture strength using different techniques 显示文摘 | Reis A Francci C Loguercio AD | 2001 | Oper Dent2001，26，3： | 1 |
| 16 | Aroma ageing trends in GC/MS profiles of liqueur wines显示文摘 | Pereira A C Reis M S Saraiva P M | 2010 | Anal Chim Acta2010，659，： | 1 |
| 17 | Sympathetic neuronal surviral induced by retinal trophic factors 显示文摘 | Reis R A Cabral de Silra M C Loureiro dos Santos N E | 2002 | J Neurobiol2002，50，1： | 1 |
| 18 | The role of dendritic cells in the induction and regulation of immunity to microbial infection显示文摘 | Reis e Sousa C Sher A Kaye P | 1999 | Curr Opin Immunol1999，11，： | 1 |
| 19 | Association between the severity of angiographic coronary artery disease and paraoxonase gene polymorphisms in the national heart,lung,and blood显示文摘 | CHEN Q REIS S E KAMMERER C M | 2003 | Am J Hum Genet2003，72，： | 1 |
| 20 | Validation of a matrix solid phase dispersion (MSPD) technique for determination of pesticides in lyophilized eggs of the chicken Gallus gallus domesticus显示文摘 | dos Reis Souza M K Moreira C O de Lima T G | 2013 | Microchem J2013，110，： | 1 |
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