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| 1 | Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9显示文摘RBPjk-dependent Notch signaling regulates both the onset of chondrocyte hypertrophy and the progression to terminal chondrocyte maturation during endochondral ossification. It has been suggested that Notch signaling can regulate Sox9 transcription, although how this occurs at the molecular level in chondrocytes and whether this transcriptional regulation mediates Notch control of chondrocyte hypertrophy and cartilage development is unknown or controversial. Here we have provided conclusive genetic evidence linking RBPjk-dependent Notch signaling to the regulation of Sox9 expression and chondrocyte hypertrophy by examining tissuespecific Rbpjk mutant(Prx1Cre;Rbpjkf/f), Rbpjk mutant/Sox9 haploinsufficient(Prx1Cre;Rbpjkf/f;Sox9f/1),and control embryos for alterations in SOX9 expression and chondrocyte hypertrophy during cartilage development. These studies demonstrate that Notch signaling regulates the onset of chondrocyte maturation in a SOX9-dependent manner, while Notch-mediated regulation of terminal chondrocyte maturation likely functions independently of SOX9. Furthermore, our in vitro molecular analyses of the Sox9 promoter and Notch-mediated regulation of Sox9 gene expression in chondrogenic cells identified the ability of Notch to induce Sox9 expression directly in the acute setting, but suppresses Sox9 transcription with prolonged Notch signaling that requires protein synthesis of secondary effectors. | Anat Kohn Timothy P Rutkowski Zhaoyang Liu Anthony J Mirando Michael J Zuscik Regis J O'Keefe Matthew J Hilton | 2015 | Bone Research2015，3，3： | 8 |
| 2 | 细胞分离培养在实验室诊断眼部单纯疱疹病毒感染疾病的误诊和漏诊情况(英文)显示文摘目的:对比聚合酶链反应(PCR)和细胞分离培养在实验室诊断眼部单纯疱疹病毒(HSV)感染疾病的作用。方法:我们对连续患者的实验室结果(PCR实验,细胞分离培养及临床诊断)及病历进行回顾性研究在诊断眼部HSV感染疾病过程中,PCR检测结果、细胞分离培养及首诊结果进行了统计比较。结果:患者581例经过检查后,520例PCR检查阴性,细胞培养阴性(89.6%);0例PCR检查阴性,细胞培养阳性(0%);27例PCR检查阳性,细胞培养阴性(4.6%);34例PCR检查阳性,细胞培养阳性(5.8%)。PCR检测阳性率高于细胞分离培养(McNemars,P=0.0001)。47例PCR检查为HSV初诊感染阳性患者中,19例患者中有14例为细胞培养阴性结果(74%),5例HSV患者因缺PCR检测结果将被误诊;28例患者中有25例患者细胞培养阳性(占89%),3例HSV患者因缺PCR检测结果将被漏诊。结论:PCR诊断眼部HSV感染优于细胞分离培养。细胞分离培养对于眼部HSV感染的非典型表现不易诊断。 | Regis P Kowalski Paul P Thompson Tara H Cronin | 2010 | 国际眼科杂志2010，10，11： | 2 |
| 3 | valuation of fractionated radiotherapy and gamma knife radiosurgery in cavernous sinus meningiomas: treatment strategy显示文摘 | Metellus P Regis J Muraceiole X | 2005 | Neurosurgery2005，57，5： | 1 |
| 4 | Gamma knife radiosurgery in the management of cavernous sinus meningiomas显示文摘 | Roche P H Regis J Dufour H | 2000 | J Neurosurg2000，93，3： | 1 |
| 5 | Paraffin/porous graphite matrix composite as a high and constant power thermal storage material 显示文摘 | Xavier P Regis O Sylvain M | 2001 | International Journal of Heat and Mass Transfer2001，44，14： | 1 |
| 6 | Comparative Advertising: Disclosing Horizontal Match Information显示文摘 | Simon P Anderson Regis R | 2009 | The Rand Journal of Economics2009，40，3： | 1 |
| 7 | Pineal region tumors and the role of stereotactic biopsy:review of the mortality,morbidity and diagnostic rates in 370 cases显示文摘 | Regis J Bouillot P Rouby-Volot F | 1996 | Neurosurgery1996，39，： | 1 |
| 8 | Radiosurgery for t rigeminal neuralgia and epilepsy显示文摘 | REGIS J BARTOLOMEI F METELLUS P | 1999 | Neurosurg Clin Nor Am1999，10，2： | 1 |
| 9 | An analysis of the transient temperature distribution in pavement heating installations 显示文摘 | Leal M Regis L V Miller P L Jr | 1972 | ASHRAE Transactions1972，78，2： | 1 |
| 10 | Testing for PPP in australia : Evidence from unit root tests against nonlinear trend stationarity alematives 显示文摘 | Cuestas J C Regis P J | 2008 | Economics Bulletin2008，，3： | 1 |
| 11 | Supravalvular aortic stenosis with sud- den cardiac death显示文摘 | VAIDEESWAR P REGI P | 2015 | Ann Pediatr Cardiol2015，8，2： | 1 |
| 12 | Cell culture isolation can miss the laboratory diagnosis of HSV ocular infection显示文摘AIM:We compared polymerase chain reaction(PCR)to cell culture isolation for the laboratory diagnosis of ocular herpes simplex virus(HSV)disease. ? METHODS:Laboratory and medical records of consecutive patients were reviewed for results of 1)HSV PCR testing,2) HSV cell culture isolation,and 3)clinical diagnosis.PCR results were statistically compared to cell culture isolation and patients initially diagnosed for ocular HSV infection. RESULTS:Of 581 cases submitted for laboratory testing, 520 were PCR negative,cell culture negative(89.6%);0 were PCR negative,cell culture positive(0%);27 were PCR positive,cell culture negative(4.6%);and 34 were PCR positive,cell culture positive(5.8%).PCR tested more positive than cell culture isolation(McNemar’s,P=0.0001).Of 47 HSV PCR positive cases with complete medical records,19 were cell culture negative for HSV and 28 were cell culture positive for HSV.Fourteen of 19 cell culture negative cases (74%)(Without PCR,5 cases of HSV would be missed)and 25 of the 28 cell culture positive cases(89%)(Laboratory testing was necessary for diagnosing 3 cases)were clinically diagnosed with HSV at the initial examination. CONCLUSION:PCR was a more definitive test for diagnosing HSV ocular infection than cell culture isolation.Cell culture isolation alone can miss an atypical presentation of HSV ocular infection. | Regis P Kowalski Paul P Thompson Tara H Cronin | 2010 | International Journal of Ophthalmology(English edition)2010，3，2： | 1 |
| 13 | Long-term outcome after gamma knife surgery for secondary trigeminal neuralgia 显示文摘 | Metellus P Dufour H | 2001 | J Neurosurg2001，95，2： | 1 |
| 14 | SAR imagesegmentation based on level set approach and G model显示文摘 | REGIS C MARQUES P FATIMA N el al | 2012 | IEEE Transactions on Pattern Analysis and Machine Intelli- gence2012，34，10： | 1 |
| 15 | Management of brain stem abscess显示文摘 | Fuentes S Bouillot P Regis J | 2001 | Br-J-Neurosurg2001，15，1： | 1 |
| 16 | Effect of gamma knife on secondary trigeminal neuralgia 显示文摘 | Metellus P Lazorthes Y | 1998 | Stereotact Funct Neurosurg1998，70，： | 1 |
| 17 | Management of brain stem abscess 显示文摘 | Fuentes S Boui llot P Regis J | 2001 | Br J Neurosurg2001，15，1： | 1 |
| 18 | Paraffin/porous-graphite-matrix composite as a high and constant power thermal storage material显示文摘 | Xavier P Regis O Sylvain M | 2001 | International Journal of Heat and Mass Transfer2001，44，： | 1 |
| 19 | Prospective controlled trial of gamma knife surgery for essential trigeminal显示文摘 | Regis J Metellus P Hayashi M | 2006 | Neuralgia Neurosurgery2006，104，4： | 1 |
| 20 | Management of brain stem abscess显示文摘 | Fuentes S Bouillot P Regis J | 2001 | Br J Neurosurg2001，15，： | 1 |
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