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| 1 | Combined alkaline and ultrasonic pretreatment of sludge before aerobic digestion显示文摘Alkaline and ultrasonic sludge disintegration can be used as the pretreatment of waste activated sludge(WAS) to promote the subsequent anaerobic or aerobic digestion.In this study,different combinations of these two methods were investigated.The evaluation was based on the quantity of soluble chemical oxygen demand(SCOD) in the pretreated sludge as well as the degradation of organic matter in the subsequent aerobic digestion.For WAS samples with combined pretreatment,the released COD levels were higher than those with ultrasonic or alkaline pretreatment alone.When combined with the ultrasonic treatment,NaOH treatment was more effcient than Ca(OH)2 for WAS solubilization.The COD levels released in various sequential options of combined NaOH and ultrasonic treatments were in the the following descending order:simultaneous treatment > NaOH treatment followed by ultrasonic treatment > ultrasonic treatment followed by NaOH treatment.For simultaneous treatment,low NaOH dosage(100 g/kg dry solid),short duration(30 min) of NaOH treatment,and low ultrasonic specific energy(7500 kJ/kg dry solid) were suitable for sludge disintegration.Using combined NaOH and ultrasonic pretreatment with optimal parameters,the degradation effciency of organic matter was increased from 38.0% to 50.7%,which is much higher than that with ultrasonic(42.5%) or with NaOH pretreatment(43.5%) in the subsequent aerobic digestion at the same retention time. | MAHAR Rasool Bux | 2009 | Journal of Environmental Sciences2009，21，3： | 40 |
| 2 | Chemical composition and antioxidant activity of certain Morus species显示文摘In the present work,the fruits of four Morus species,namely Morus alba (white mulberry),Morus nigra (black mulberry),Morus laevigata (large white fruit),and Morus laevigata (large black fruit),were analyzed for proximate composition,essential minerals,and antioxidant potentials.For this purpose,the ripe fruits were collected from the northern regions of Pakistan.The major nutritional components moisture,ash,lipids,proteins,fibres,carbohydrates,and total sugar) were found to be in the suitable range along with good computed energy.Total dry weight,pH,and titratable acidity (percent citric acid) were (17.60±1.94)–(21.97±2.34) mg/100 g,(3.20±0.07)–(4.78±0.15),and (0.84±0.40)%–(2.00±0.08)%,respectively.Low riboflavin (vitamin B2) and niacin (vitamin B3) contents were recorded in all the fruits,while ascorbic acid (vitamin C) was in the range from (15.20±1.25) to (17.03±1.71) mg/100 g fresh weight (FW).The mulberry fruits were rich with regard to the total phenol and alkaloid contents,having values of (880±7.20)–(1650±12.25) mg/100 g FW and (390±3.22)–(660±5.25) mg/100 g FW,respectively.Sufficient quantities of essential macro-(K,Ca,Mg,and Na) and micro-(Fe,Zn,and Ni) elements were found in all the fruits.K was the predominant element with concentration ranging from (1270±9.36) to (1731±11.50) mg/100 g,while Ca,Na,and Mg contents were (440±3.21)–(576±7.37),(260±3.86)–(280±3.50),and (240±3.51)–(360±4.20) mg/100 g,respectivly.The decreasing order of micro-minerals was Fe>Zn>Ni.The radical scavenging activity of methanolic extract of fruits was concentration-dependent and showed a correlation with total phenolic constituents of the respective fruits.Based on the results obtained,mulberry fruits were found to serve as a potential source of food diet and natural antioxidants. | Mohammad IMRAN Hamayun KHAN Mohibullah SHAH Rasool KHAN Faridullah KHAN | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，12： | 14 |
| 3 | Kinematic Analysis and Design of a 3-DOF Translational Parallel Robot显示文摘Parallel mechanisms are widely used in various fields of engineering and industrial applications such as machine tools, flight simulators, earthquake simulators, medical equipment, etc. Parallel mechanisms are restricted to some limitations such as irregular workspace, existence of singular points and complexity of control systems which should be studied and analyzed for effective and efficient use. In this research, a new machine tool with parallel mechanism which has three translational degrees of freedom is studied and the workspace and singular points are determined by deriving analytical equations and then utilizing of Matlab software. To do so, forward and inverse kinematics of the mechanism are obtained and workspace and singular points are calculated using a search algorithm.Afterward, in order to validate the results, the proposed mechanism is simulated in automatic dynamics analysis of mechanical systems(ADAMS) software. Moreover, in order to investigate the quality of robot performance and dexterity of the mechanism in its workspace,global dexterity index(GDI) of the robot is calculated using Jacobean matrix at different positions of the mobile platform. | Mahmood Mazare Mostafa Taghizadeh M. Rasool Najafi | 2017 | International Journal of Automation and computing2017，14，4： | 13 |
| 4 | Piperine,an active ingredient of black pepper attenuates acetaminophen-induced hepatotoxicity in mice显示文摘Objective:To explore the hepatoprotective and antioxidant effects of piperine against acetaminophen-induced hepatotoxicity in mice.Methods:In mice,hepatotoxicity was induced by a single dose of acetaminophen(900 mg/kg b.w.i.p.).Piperine(25 mg/kg b.w.i.p.) and standard drug silymarin(25 mg/kg b.w.i.p.) were given to mice,30 min after the single injection of acetaminophen.After 4 h,the mice were decapitated.Activities of liver marker enzymes [(aspartate transaminase(AST),alanine transaminase(ALT),and alkaline phosphatase(ALP)]and inflammatory mediator tumour necrosis factor-alpha(TNF-α) were estimated in serum,while lipid peroxidation and antioxidant status(superoxide dismutase,catalase,glutathione peroxidase, glutathione reductase,glutathione-s-transferase and glutathione) were determined in liver homogenate of control and experimental mice.Results:Acetaminophen induction(900 mg/kg b.w.i.p.) significantly increased the levels of liver marker enzymes,TNF-α,and lipid peroxidation,and caused the depletion of antioxidant status.Piperine and silymarin treatment to acetaminophen challenged mice resulted in decreased liver marker enzymes activity,TNF-αand lipid peroxidation levels with increase in antioxidant status.Conclusions:The results clearly demonstrate that piperine shows promising hepatoprotective effect as comparable to standard drug silymarin. | Evan Prince Sabina Annie Deborah Harris Souriyan Deborah Jackline Mahaboob Khan Rasool | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，12： | 7 |
| 5 | Validity and cost comparison of ^(14)carbon urea breath test for diagnosis of H Pylori in dyspeptic patients显示文摘AIM: To validate and compare the cost of microdose 14C urea breath test (UBT) with histology and rapid urease test for the diagnosis of H Pylori. METHODS: Ninety-four consecutive patients with dyspeptic symptoms undergoing gastroscopy were enrolled. Gastric biopsies were taken for histology and rapid urease test. UBT was performed after gastroscopy by microdose 14C urea capsules. Sensitivity, specificity and accuracy of UBT were calculated and compared with histology and rapid urease test. Cost comparison of these tests was also performed. RESULTS: H pylori was diagnosed by histology and rapid urease test in 66 (70%) and 61 (65%) patients, while 14C UBT detected infection in 63 (67%). Accuracy of UBT was 93% in comparison with histology while its positive and negative predictive values were 97% and 84%, respectively. Comparison of 14C UBT with rapid urease test gives an accuracy of 96%, with positive and negative predictive values of 95% and 97%, respectively. These results were highly reproducible with a Kappa test (P value < 0.001). Cost of histology or rapid urease test with gastroscopy was 110 USD or 95 USD respectively while the cost of UBT was 15 USD. CONCLUSION: Microdose 14C UBT was comparable to histology and rapid urease test. 14C UBT is an economical, self sufficient and suitable test to diagnose active H pylori infection in less developed countries. | Shahid Rasool Shahab Abid Wasim Jafri | 2007 | World Journal of Gastroenterology2007，13，6： | 5 |
| 6 | Autoantibody profiles in autoimmune hepatitis and chronic hepatitis C identifies similarities in patients with severe disease显示文摘AIM To determine how the auto-antibodies(Abs) profiles overlap in chronic hepatitis C infection(CHC) and autoimmune hepatitis(AIH) and correlate to liver disease.METHODS Levels of antinuclear Ab, smooth muscle antibody(SMA) and liver/kidney microsomal-1(LKM-1) Ab and markers of liver damage were determined in the sera of 50 patients with CHC infection, 20 AIH patients and 20 healthy controls using enzyme linked immunosorbent assay and other immune assays. RESULTS We found that AIH patients had more severe liver disease as determined by elevation of total Ig G, alkaline phosphatase, total serum bilirubin and serum transaminases and significantly higher prevalence of the three non-organ-specific autoantibodies(auto-Abs) than CHC patients. Antinuclear Ab, SMA and LKM-1 Ab were also present in 36% of CHC patients and related to disease severity. CHC cases positive for auto-Abs were directly comparable to AIH in respect of most markers of liver damage and total Ig G. These cases had longer disease duration compared with auto-Ab negative cases, but there was no difference in gender, age or viral load. KLM-1+ Ab CHC cases showed best overlap with AIH. CONCLUSION Auto-Ab levels in CHC may be important markers of disease severity and positive cases have a disease similar to AIH. Auto-Abs might have a pathogenic role as indicated by elevated markers of liver damage. Future studies will unravel any novel associations between these two diseases, whether genetic or other. | Kawa Amin Aram H Rasool Ali Hattem Taha AM Al-Karboly Taher E Taher Jonas Bystrom | 2017 | World Journal of Gastroenterology2017，23，8： | 5 |
| 7 | 活性炭负载硫化锡纳米颗粒作为高效可重复使用Lewis酸催化剂催化三组分一锅法合成4H-吡喃[2,3-c]吡唑衍生物(英文)显示文摘Tin sulfide nanoparticles(SnS -NPs) were prepared in aqueous solution at room temperature on the surface of activated carbon(AC) and were investigated using field-emission scanning electron mi-croscopy(FE-SEM), transmission electron microscopy(TEM), X-ray diffraction, reflective ultravio-let-visible spectrophotometry, and spectrofluorimetry. Calculations based on the SEM and TEM images showed that the sizes of the SnS -NPs immobilized on the AC were 30–70 nm. The prepared nanocomposite was used as a heterogeneous Lewis acid catalyst for the three-components one-pot synthesis of 4H-pyrano[2,3-c]pyrazole derivatives in ethanol at 80 ℃. The reactions were efficiently performed in the presence of the prepared catalyst in short reaction times, and gave the desired products in high yields. This catalyst can be easily recovered by simple filtration and recycled up to eight consecutive times without significant loss of its efficiency. | Nasir Iravani Mosadegh Keshavarz Hossein Ali Shojaeian Kish Rasool Parandvar | 2015 | 催化学报2015，36，4： | 4 |
| 8 | STABILITY ANALYSIS OF A CAPACITIVE FGM MICRO-BEAM USING MODIFIED COUPLE STRESS THEORY显示文摘Based on the Modified Couple Stress Theory,a functionally graded micro-beam under electrostatic forces is studied.The FGM micro-beam is made of two materials and material properties vary continuously along the beam thickness according to a power-law.Dynamic and static pull-in voltages are obtained and it is shown that the static and dynamic pull-in voltages for some materials cannot be obtained using classic theories and components of couple stress must be taken into account.In addition,it is shown that the values of pull-in voltages depend on the variation through the thickness of the volume fractions of the two constituents. | Behrokh Abbasnejad Ghader Rezazadeh Rasool Shabani | 2013 | Acta Mechanica Solida Sinica2013，26，4： | 4 |
| 9 | 对香豆酸对佐剂性关节炎大鼠的抗过氧化作用(英文)显示文摘目的:研究对香豆酸,一种食物中含有的酚酸对佐剂性关节炎大鼠的抗过氧化治疗作用。方法:大鼠右后肢脚垫皮内注射0.1mL弗氏完全佐剂诱发关节炎。于佐剂注射后第11~18天连续给药8d,治疗组用药为对香豆酸(100mg/kg大鼠体质量,腹腔内给药),阳性对照组药物为吲哚美辛(3mg/kg大鼠体质量,腹腔内给药)。对佐剂性关节炎大鼠的肝脏、脾脏、血浆内脂质过氧化作用水平和抗氧化水平的变化进行测量,同时分析大鼠后肢的影像学改变以衡量对香豆酸的抗氧化作用。结果:佐剂性关节炎大鼠经对香豆酸治疗后,脂质过氧化作用和抗氧化水平恢复近正常值。影像学观察发现,治疗组大鼠的软组织肿胀、骨侵蚀及关节间隙狭窄情况得到缓解。结论:对香豆酸对佐剂性关节炎大鼠有明显的治疗作用,这种治疗作用可能与其抗氧化作用相关。 | Samuel Joshua Pragasam Vachana Murunikara Evan Prince Sabina Mahaboobkhan Rasool | 2012 | 中西医结合学报2012，10，8： | 4 |
| 10 | Gastric juice for the diagnosis of H pylori infection in patients on proton pump inhibitors显示文摘AIM: To determine the efficacy of gastric juice polymerase chain reaction (PCR) for the detection of H pylori infection in comparison with histology and gastric antral biopsy PCR in patients on a proton pump inhibitor (PPI). METHODS: Eighty-five consecutive patients with dyspeptic symptoms were enrolled. Gastric biopsies for histology, PCR and gastric juice were collected at endoscopy for PCR of the H pylori urease C gene (ure C). Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), accuracy, positive and negative likelihood ratio for PCR of gastric juice for the H pylori ure C gene was compared to histology and gastric antral biopsy H pylori ure C PCR in patients with and without PPI. RESULTS: Gastric juice PCR was positive in 66 (78%) patients. Histology showed H pylori associated gastritis in 57 (67%). Gastric biopsy PCR was positive in 72 (85%). In patients not taking PPI, the sensitivity, specificity, PPV, NPV, accuracy and positive and negative likelihood ratio for gastric juice PCR were 89%, 72%, 91%, 67%, 90%, 85%, 3.1 and 0.1 respectively. In patients on PPI these values were 86%, 100%%, 100%, 29%, 86%, 9.5 and 1.4, respectively. CONCLUSION: Gastric juice PCR for the diagnosis of H pylori infection has increased sensitivity compared to histology with PPI. The use of gastric juice PCR is recommended to confirm H pylori status in patients taking PPIs. | Javed Yakoob Shahid Rasool Zaigham Abbas Wasim Jafri Shahab Abid Muhammad Islam Zubair Ahmad | 2008 | World Journal of Gastroenterology2008，14，10： | 4 |
| 11 | Physicochemical characteristics of various milk samples available in Pakistan显示文摘We report physicochemical characteristics of various kinds of liquid milk commercially available in Pakistan in comparison with those of fresh natural milk from animals. Milk samples were collected from local markets at Peshawar, Pakistan, and analyzed for their physical features, including moisture, total solids, specific gravity, conductivity, viscosity and titratable acidity (lactic acid equivalent), and chemical components and macro-minerals, including total protein, casein, lactose, ash and minerals (Na, K and Mg). These items were compared with the physicochemical characteristics of the fresh natural milk samples from buffalo, cow and goat. The results were also compared with reported nutritional quality of milk from various countries and World Health Organization (WHO) standards. We found that all the physical features and chemical components of commercially available milk in Pakistan markets meet WHO's requirements, except for Na, K, Ca and Mg, which are below the standards. | Mohammad IMRAN Hamayun KHAN Syed Shah HASSAN Rasool KHAN | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，7： | 4 |
| 12 | Efficacy of boswellic acid on lysosomal acid hydrolases,lipid peroxidation and anti-oxidant status in gouty arthritic mice显示文摘Objective:To evaluate the efficacy of boswellic acid against monosodium urate crystal-induced inflammation in mice.Methods:The mice were divided into four experimental groups.GroupⅠserved as control;mice in groupⅡwere injected with monosodium urate crystal;groupⅢconsisted of monosodium urate crystal-induced mice who were treated with boswellic acid(30mg/kg/b.w.);groupⅣcomprised monosodium urate crystal-induced mice who were treated with indomethacin(3mg/kg/b.w.).Paw volume and levels/activities of lysosomal enzymes,lipid peroxidation,anti-oxidant status and inflammatory mediator TNF-αwere determined in control and monosodium urate crystal-induced mice.In addition,the levels ofβ-glucuronidase and lactate dehydrogenase were also measured in monosodium urate crystal-incubated polymorphonuclear leucocytes(PMNL)in vitro.Results:The activities of lysosomal enzymes,lipid peroxidation,and tumour necrosis factor-αlevels and paw volume were increased significantly in monosodium urate crystal-induced mice,whereas the activities of antioxidant status were in turn decreased.However,these changes were modulated to near normal levels upon boswellic acid administration.In vitro,boswellic acid reduced the level ofβ-glucuronidase and lactate dehydrogenase in monosodium urate crystal-incubated PMNL in concentration dependent manner when compared with control cells.Conclusions:The results obtained in this study further strengthen the anti-inflammatory/antiarthritic effect of boswellic acid,which was already well established by several investigators. | Evan Prince Sabina Haridas Indu Mahaboobkhan Rasool | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，2： | 4 |
| 13 | Traditional and modern aspects of hemorrhoid treatment in Iran:a review显示文摘Hemorrhoidal disease is a prevalent anorectal condition which is generally not managed well with current pharmacologic interventions. However, in Iranian traditional medicine(ITM) there are numerous plants with hemorrhoid-healing properties. The present research assembled plants with hemorrhoidhealing properties in ITM; their related pharmacological effects, phytochemical constituents and mechanisms of action in the modern medicine were also gathered. For this purpose, leading ITM textbooks were searched for plants with hemorrhoid-healing effects. Further, in vitro, in vivo and clinical studies on the most cited species were considered using scientific databases. Studying ITM textbooks revealed37 medicinal plants with hemorrhoid-healing effects. Among the mentioned herbal medicines, six species, including Allium ampeloprasum, Phyllanthus emblica, Aloe vera, Terminalia chebula, Vitis vinifera and Commiphora mukul, had the largest number of related pharmacological effects documented in scientific databases. These herbs from ITM should be considered as important resources for producing novel drugs for hemorrhoid treatment. | Sahar Dehdari Homa Hajimehdipoor Somayeh Esmaeili Rasool Choopani Seyed Alireza Mortazavi | 2018 | Journal of Integrative Medicine2018，16，2： | 3 |
| 14 | Effects of irrigation water regime, soil clay content and their combination on growth,yield,and water use efficiency of rice grown in South China显示文摘To investigate the effect of irrigation regime,soil clay content and their combination on growth,yield,and water productivity of rice,a shelter experiment was conduct using Randomized Complete Block Design(RCBD)with a factorial arrangement of treatments with four replications.Irrigation regime was the main treatment investigated,set in three levels as R(30 mm-100%)(100%of saturation and 30 mm flooded),R(30 mm-90%)(90%of saturation and 30 mm flooded)and R(30 mm-70%)(70%saturation and 30 mm flooded),respectively.The sub-treatment was soil type,set in three levels as 40%,50%and 60%clay content,respectively.Results showed that irrigation regime and soil clay content had significant effects on growth,yield and water productivity of rice.However,their combination showed no significant impact on panicles number,root biomass,harvest index and irrigation water productivity.Higher soil clay content results in increase in growth,yield,and water productivity of rice.The total water consumption during R(30 mm-100%)was higher than that during R(30 mm-90%)and R(30 mm-70%)because the latter two saturation levels led to the cracking of soil and decrease of total number of irrigations.Cracks were consistently getting more serious with the reduction in soil water content and the increase in soil clay content.Cracks in soil will preferentially become the major routes of water losses,thus water percolation during R(30 mm-70%)was higher than that during R(30 mm-90%)and R(30 mm-100%)after each irrigation event.The total water use under R(30 mm-70%)exceeded the water consumption under R(30 mm-90%)due to the great amount of soil cracking as well as the excessive volume of standing water depth.Considering water consumption and grain yield,the following conclusion can be reached:(i)The reduction in water consumption was greater than the reduction in grain yield in the case of drying soil 10%below saturation before reflooding.(ii)The reduction in water consumption was less than the reduction in grain yield in the case of drying soil 30%below saturation before reflooding;(iii)The increase in water use was greater than the increase in grain yield in the case of maintaining soil moisture at 100%of saturation before reflooding.Therefore,the water use efficiency was recorded in the order of R(30 mm-90%)>R(30 mm-100%)>R(30 mm-70%). | Yousef Alhaj Hamoud Xiangping Guo Zhenchang Wang Sheng Chen Ghulam Rasool | 2018 | International Journal of Agricultural and Biological Engineering2018，11，4： | 3 |
| 15 | 胶质气体泡沫基泡沫水泥体系显示文摘为了解决常规泡沫水泥存在的密度高、泡沫不稳定、抗压强度低、孔隙度高、有效期短等缺点,研发了一种新型的胶质气体泡沫(CGA)基泡沫水泥体系并进行性能评价。将CGA作为泡沫组分加入基浆,从优化粒度分布的角度考虑加入空心球和微硅石继续优化配方。通过孔隙度、渗透率、强度、脆性、弹性、自由水含量、泡沫稳定性和密度测试等评价CGA基泡沫水泥体系性能,实验结果表明:泡沫占比为10%时,水泥密度降到1040 kg/m3;水泥体系中形成了稳定的微泡网络结构且不受高温高压影响;最优CGA基泡沫水泥自由水含量为零,孔隙度为24%,渗透率为0.7×103μm^2,弹性模量低、泊松比高,抗压强度合理,表现出韧性特征,具有更强的弹性和柔性,可承受区域地应力。 | VELAYATI Arian ROOSTAEI Morteza RASOOLIMANESH Rasool SOLEYMANI Mohammad FATTAHPOUR Vahidoddin | 2019 | 石油勘探与开发2019，46，6： | 3 |
| 16 | 生姜提取物6-姜酚对对乙酰氨基酚致小鼠肝脏毒性的保护作用(英文)显示文摘目的:研究生姜提取物6-姜酚对对乙酰氨基酚致小鼠肝脏毒性的保护作用。方法:实验组小鼠在腹腔注射对乙酰氨基酚(900 mg/kg)30 min后,分别给予6-姜酚(30 mg/kg)或标准对照药水飞蓟素(25 mg/kg)。注射对乙酰氨基酚4 h后处死小鼠,检测血清中天冬氨酸氨基转移酶、丙氨酸氨基转移酶、碱性磷酸酶活性,总胆红素的含量及肝匀浆中脂质过氧化及抗氧化情况,如超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶、谷胱甘肽还原酶、谷胱甘肽转移酶活性及还原型谷胱甘肽含量。结果:与对照组相比,6-姜酚及水飞蓟素均能显著降低对乙酰氨基酚引起的小鼠血清天冬氨酸氨基转移酶、丙氨酸氨基转移酶、碱性磷酸酶活性及总胆红素含量的升高(P<0.05)。此外,6-姜酚及水飞蓟素有效控制了肝脏内丙二醛的形成及各种抗氧化酶的降低(P<0.05)。结论:本研究的结果证实了6-姜酚具有与水飞蓟素相当的保肝作用。 | Evan Prince Sabina Samuel Joshua Pragasam Suresh Kumar Mahaboobkhan Rasool | 2011 | 中西医结合学报2011，9，11： | 3 |
| 17 | A comparative overview of general risk factors associated with the incidence of colorectal cancer显示文摘 | Sabha Rasool Showkat Ahmad Kadla Vamiq Rasool Bashir Ahmad Ganai | 2013 | Tumor Biology2013，，： | 2 |
| 18 | Evaluation of biomarkers, genetic mutations, and epigenetic modifications in early diagnosis of pancreatic cancer显示文摘BACKGROUND Pancreatic cancer(PC)is one of the deadliest malignancies with an alarming mortality rate.Despite significant advancement in diagnostics and therapeutics,early diagnosis remains elusive causing poor prognosis,marred by mutations and epigenetic modifications in key genes which contribute to disease progression.AIM To evaluate the various biological tumor markers collectively for early diagnosis which could act as prognostic biomarkers and helps in future therapeutics of PC in Kashmir valley.METHODS A total of 50 confirmed PC cases were included in the study to evaluate the levels of carbohydrate antigen 19-9(CA 19-9),tissue polypeptide specific antigen(TPS),carcinoembryonic antigen(CEA),vascular endothelial growth factor-A(VEGF-A),and epidermal growth factor receptor(EGFR).Mutational analysis was performed to evaluate the mutations in Kirsten rat sarcoma(KRAS),Breast cancer type 2(BRCA-2),and deleted in pancreatic cancer-4(DPC-4)genes.However,epigenetic modifications(methylation of CpG islands)were performed in the promoter regions of cyclin-dependent kinase inhibitor 2A(p16;CDKN2A),MutL homolog 1(hMLH1),and Ras association domain-containing protein 1(RASSF1A)genes.RESULTS We found significantly elevated levels of biological markers CA 19-9(P≤0.05),TPS(P≤0.05),CEA(P≤0.001),and VEGF(P≤0.001).Molecular genetic analysis revealed that KRAS gene mutation is predominant in codon 12(16 subjects,P≤0.05),and 13(12 subjects,P≤0.05).However,we did not find a mutation in DPC-4(1203G>T)and BRCA-2(617delT)genes.Furthermore,epigenetic modification revealed that CpG methylation in 21(P≤0.05)and 4 subjects in the promoter regions of the p16 and hMLH1 gene,respectively.CONCLUSION In conclusion,CA 19-9,TPS,CEA,and VEGF levels were significantly elevated and collectively have potential as diagnostic and prognostic markers in PC.Global data of mutation in the KRAS gene commonly in codon 12 and rare in codon 13 could augment the predisposition towards PC.Additionally,methylation of the p16 gene could also modulate transcription of genes thereby increasing the predisposition and susceptibility towards PC. | Bilal Rah Manzoor Ahmad Banday Gh Rasool Bhat Omar J Shah Humira Jeelani Fizalah Kawoosa Tahira Yousuf Dil Afroze | 2021 | World Journal of Gastroenterology2021，27，36： | 2 |
| 19 | Morpho-Physiological,Biochemical and Molecular Adaptation of Millets to Abiotic Stresses:A Review显示文摘Abiotic stresses such as drought,heat,cold,nutrient deficiency,excess salt and hazardous metals can hamper plantgrowth and development.Intensive agriculture of only a few major staple food crops that are sensitive and intolerant to environmental stresses has led to an agrarian crisis.On the other hand,nutritionally rich,gluten free and stress tolerant plants like millets are neglected and underutilized.Millets sustain about one-third of the world’s population and show exceptional tolerance to various abiotic and biotic stresses.Millets are C4 plants that are adapted to marginal and dry lands of arid and semi-arid regions,and survive low rainfall and poor soils.Abiotic stresses significantly affect plant growth which ultimately results in reduced crop yields.However,various adaptation mechanisms have evolved in millets to withstand different stresses.This review aims at exploring various of these morphophysiological,biochemical and molecular aspects of mechanisms in millets.Morphological adaptations include short life span,smallplant height and leaf area,dense root system,adjusted flowering time,increased root and decreased shoot lengths,high tillering,and leaf folding.A high accumulation of various osmoprotectants(proline,soluble sugars,proteins)improves hyperosmolarity and enhances the activity of antioxidant enzymes(e.g.,Ascorbate peroxidase,Superoxide dismutase,Catalase,Peroxidase)providing defense against oxidative damage.Physiologically,plants show low photosynthetic and stomatal conductance rates,and root respiration which help them to escape from water stress.Molecular adaptations include the upregulation of stress-related transcriptional factors,signalling genes,ion transporters,secondary metabolite pathways,receptor kinases,phytohormone biosynthesis and antioxidative enzymes.Lack of genetic resources hampers improvement of millets.However,several identified and characterized genes for stress tolerance can be exploited for further development of millet resilience.This will provide them with an extra characteristic plant resistance to withstand environmental pressures,besides their excellent nutritional value over the conventional staple crops like rice,wheat and maize. | Seerat Saleem Naveed Ul Mushtaq Wasifa Hafiz Shah Aadil Rasool Khalid Rehman Hakeem Reiaz Ul Rehman | 2021 | Phyton-International Journal of Experimental Botany2021，90，5： | 2 |
| 20 | Evaluation of the Effects of Vaccinium arctostaphylos L. Fruit Extract on Serum Lipids and hs-CRP Levels and Oxidative Stress in Adult Patients with Hyperlipidemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial显示文摘 | Rasool Soltani Mustafa Hakimi Sedigheh Asgary Syed Mustafa Ghanadian Mahtab Keshvari Nizal Sarrafzadegan Kashmira Nanji | 2014 | Evidence-Based Complementary and Alternative Medicine2014，，： | 2 |
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