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| 1 | 饮食、营养及癌症风险:已知与前景显示文摘几十年来科学家们就认为,营养在癌症发展中起着重要的作用。早在20世纪60年代就有流行病学研究显示,不同人群的癌症发病率差别非常大,而且从癌症低发国家移民到高发国家后,移民们的癌症发病率可能上升到与移民国家原住民的癌症发病率相当,甚至更高1-2。这些观察结果提示环境是导致癌症发生的重要因素。 | Timothy J Key Kathryn E Bradbury Aurora Perez-Comago Rashmi Sinha Konstantinos K Tsilidis Shoichiro Tsugane 徐欣悦(译) 严雪敏(校) | 2020 | 英国医学杂志中文版2020，23，7： | 5 |
| 2 | Estrogen receptor expression in chronic hepatitis C and hepatocellular carcinoma pathogenesis显示文摘AIM To investigate gender-specific liver estrogen receptor(ER) expression in normal subjects and patients with hepatitis C virus(HCV)-related cirrhosis and hepatocellular carcinoma(HCC).METHODS Liver tissues from normal donors and patients diagnosed with HCV-related cirrhosis and HCV-related HCC were obtained from the NIH Liver Tissue and Cell Distribution System. The expression of ER subtypes, ERα and ERβ, were evaluated by Western blotting and real-time RT-PCR. The subcellular distribution of ERα and ERβ was further determined in nuclear and cytoplasmic tissue lysates along with the expression ofinflammatory [activated NF-κB and IκB-kinase(IKK)] and oncogenic(cyclin D1) markers by Western blotting and immunohistochemistry. The expression of ERα and ERβ was correlated with the expression of activated NF-κB, activated IKK and cyclin D1 by Spearman's correlation. RESULTS Both ER subtypes were expressed in normal livers but male livers showed significantly higher expression of ERα than females(P < 0.05). We observed significantly higher m RNA expression of ERα in HCV-related HCC liver tissues as compared to normals(P < 0.05) and ERβ in livers of HCV-related cirrhosis and HCV-related HCC subjects(P < 0.05). At the protein level, there was a significantly higher expression of nuclear ERα in livers of HCV-related HCC patients and nuclear ERβ in HCV-related cirrhosis patients as compared to normals(P < 0.05). Furthermore, we observed a significantly higher expression of phosphorylated NF-κB and cyclin D1 in diseased livers(P < 0.05). There was a positive correlation between the expression of nuclear ER subtypes and nuclear cyclin D1 and a negative correlation between cytoplasmic ER subtypes and cytoplasmic phosphorylated IKK in HCV-related HCC livers. These findings suggest that dysregulated expression of ER subtypes following chronic HCVinfection may contribute to the progression of HCVrelated cirrhosis to HCV-related HCC.CONCLUSION Gender differences were observed in ERα expression in normal livers. Alterations in ER subtype expression observed in diseased livers may influence genderrelated disparity in HCV-related pathogenesis. | Janaki K Iyer Mamta Kalra Anil Kaul Mark E Payton Rashmi Kaul | 2017 | World Journal of Gastroenterology2017，23，37： | 5 |
| 3 | Meat consumption,cooking practices,meat mutagens,and risk of prostate cancer显示文摘 | JOHN E M STERN M C RASHMI S | 2011 | Nutrition and Cancer2011，63，4： | 1 |
| 4 | Improving scheduling of tasks in a heterogeneous environment 显示文摘 | RASHMI E AGRAWAL D P | 2004 | IEEE Transactions on Parallel and Distributed Systems2004，15，2： | 1 |
| 5 | Partial purification and characterization of protease of Bacillus proteolyticus CFR3001 iso- lated from fish processing waste and its antibacterial activities显示文摘 | BHASKAR N SUDEEPA E S RASHMI H N | 2007 | Bioresource Technology2007，98，： | 1 |
| 6 | Sol-gel preparation of mesoporous sodium aluminosilicate glasses: mechanistic and structural investigations by solid state nuclear magnetic resonance 显示文摘 | Rashmi R Deshpande Hellmnt E | 2009 | Journal of Materials Chemistry2009，19，： | 1 |
| 7 | Evaluation of estrogenic activity of alcoholic extracts of rhizomes of Curculigo orchioides显示文摘 | Vijayanarayana K Rashmi S R Chandrashekhar K S Subrah manyam E V | 2007 | J Ethnopharma col2007，114，： | 1 |
| 8 | Partial purification and characterization of protease of Bacillus proteolyticus-CFR3001 isolated from fish processing waste and its antibacterial activities显示文摘 | Bhaskar N Sudeepa E S Rashmi H N | 2007 | Bioresource Technology2007，98，27： | 1 |
| 9 | Partial purification and characterization of protease of Bacillus proteolyticus CFR3001 isolated from fish processing waste and its antibacterial activities 显示文摘 | Bhaskar N Sudeepa E S Rashmi H N | 2007 | Bioresource Technology2007，98，14： | 1 |
| 10 | Sol-gel preparationof mesoporous sodium aluminosilicate glasses : mechanis-tic and structural investigations by solid state nuclearmagnetic resonance 显示文摘 | Rashmi R Deshpande Hellmut E | 2009 | J Mater Chem2009，19，： | 1 |
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