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| 1 | Mixed epithelial endocrine neoplasms of the colon and rectum–An evolution over time:A systematic review显示文摘BACKGROUND Mixed tumors of the colon and rectum,composed of a combination of epithelial and endocrine elements of benign and malignant potential are rare neoplasms.These can occur anywhere in the gastrointestinal tract and are often diagnosed incidentally.Though they have been a well-documented entity in the pancreas,where the exocrine-endocrine mixed tumors have been known for a while,recognition and accurate diagnosis of these tumors in the colon and rectum,to date,remains a challenge.This is further compounded by the different terminologies that have been attributed to these lesions over the years adding to increased confusion and misclassification.Therefore,dedicated literature reviews of these lesions in the colon and rectum are inconsistent and are predominantly limited to case reports and case series of limited case numbers.Though,most of these tumors are high grade and of advanced stage,intermediate and low grade lesions of these mixed tumors are also increasingly been reported.There are no established independent consensus based guidelines for the therapeutic patient management of these unique lesions.AIM To provide a comprehensive targeted literature review of these complex mixed tumors in the colon and rectum that chronicles the evolution over time with summarization of historical perspectives of terminology and to further our understanding regarding their pathogenesis including genomic landscape,clinicoradiological features,pathology,treatment,prognosis,the current status of the management of the primary lesions,their recurrences and metastases.METHODS A comprehensive review of the published English literature was conducted using the search engines PubMed,MEDLINE and GOOGLE scholar.The following search terms[“mixed tumors colon”OR mixed endocrine/neuroendocrine tumor/neoplasm/lesion colon OR adenocarcinoma and endocrine/neuroendocrine tumor colon OR mixed adenocarcinoma and endocrine/neuroendocrine carcinoma colon OR Amphicrine tumors OR Collision tumors]were used.Eligibility criteria were defined and all potential relevant items,including full articles and/or abstracts were independently reviewed,assessed and agreed upon items were selected for in-depth analysis.RESULTS In total 237 full articles/abstracts documents were considered for eligibility of which 45 articles were illegible resulting in a total of 192 articles that were assessed for eligibility of which 139 have been selected for reference in this current review.This seminal manuscript is a one stop article that provides a detailed outlook on the evolution over time with summarization of historical perspectives,nomenclature,clinicoradiological features,pathology,treatment,prognosis and the current status of the management of both the primary lesions,their recurrences and metastases.Gaps in knowledge have also been identified and discussed.An important outcome of this manuscript is the justified proposal for a new,simple,clinically relevant,non-ambiguous terminology for these lesions to be referred to as mixed epithelial endocrine neoplasms(MEENs).CONCLUSION MEEN of the colon and rectum are poorly understood rare entities that encompass an extensive range of heterogeneous tumors with a wide variety of combinations leading to tumors of high,intermediate or low grade malignant potential.This proposed new revised terminology of MEEN will solve the biggest hurdle of confusion and misclassification that plagues these rare unique colorectal neoplasms thus facilitating the future design of multi institutional prospective randomized controlled clinical trials to develop and evaluate newer therapeutic strategies that are recommended for continued improved understanding and personal optimization of clinical management of these unique colorectal neoplasms. | Rani Kanthan Suresh Tharmaradinam Tehmina Asif Shahid Ahmed Selliah C Kanthan | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 2 | An empirical study of machine learning techniques for affect recognition in human-robot interaction显示文摘 | RANI P LIU C SARKAR N | 2006 | Pattern Anal Applic2006，9，1： | 1 |
| 3 | Improving the sensitivity of a quartz crystal microbalance for biosensing by using porous gold显示文摘 | Van Noort D Rani R Mandenius C F | 2001 | Mikrochim Acta2001，136，12： | 1 |
| 4 | Pregnancy in Robert's uterus显示文摘 | Rani SS Damyanti S Pooja C | 2009 | J Obstet Gynecol India2009，59，6： | 1 |
| 5 | High -throughput screen identifies small molecule inhibitors targeting acetyl- transferase activity of Mycobacterium tuberculosis GlmU 显示文摘 | Rani C Mehra R Sharma R | 2015 | Tuberculosis ( Edinb)2015，95，6： | 1 |
| 6 | L-ysophosphatidylcholine regulates human microvascular endothelial cell expression of chemokines显示文摘 | MURUGESAN G SANDHYA RANI M R GERBER C E | 2003 | J Mol Cell Cardiol2003，35，11： | 1 |
| 7 | A theory of economic development显示文摘 | Fei J C H Ranis G | 1961 | American Economic Review1961，，57： | 1 |
| 8 | Molecular imprinted nanoelectrodes for ultra sensitive detection of ovarian cancer marker显示文摘 | VISWANATHAN S RANI C RIBEIRO S DELERUE-MATOS C | 2012 | Biosensors and Bioelectronics2012，33，1： | 1 |
| 9 | Biofilm-control strategies based on enzymicdisruption of the extracellular polymeric substancematrix-a modelling study 显示文摘 | Xavier JB Picioreanu C Rani SA | 2005 | Microbiology2005，151，12： | 1 |
| 10 | A theory of economic development显示文摘 | Ranis Gustav Fei J C H | 1961 | American Economic Review1961，51，： | 1 |
| 11 | The Ranis-Fei Model of Economic Development: a Reply 显示文摘 | RANIS G FEI J C H | 1963 | American Economic Review1963，53，3： | 1 |
| 12 | A theory of economic development显示文摘 | Ranis G Fei J C H | 1961 | American Economic Review1961，，4： | 1 |
| 13 | Carnitine as a free radical scavenger in aging 显示文摘 | Juliet Arochia Rani P Panneerselvam C | 2001 | Exp Gerontol2001，36，10： | 1 |
| 14 | Capital-labor Ratios in Theory and in History: Reply 显示文摘 | FEI J C H RANIS G | 1964 | American Economic Review1964，54，6： | 1 |
| 15 | A Theory of Economic Development显示文摘 | Ranis G Fei J C | 1961 | American Economic Review1961，51，4： | 1 |
| 16 | Computationally Guided Identification of Novel Mycobacterium tuberculosis GlmU Inhibitory Leads, Their Optimization, and in Vitro Validation显示文摘 | Mehra R Rani C Mahajan P | 2016 | ACS Comb Sci2016，18，2： | 1 |
| 17 | A Theory of Economic Development 显示文摘 | Ranis G Fei J C H | 1961 | The American Economic Review1961，51，4： | 1 |
| 18 | 查看详情显示文摘 | Viswanathan S Rani C Ribeiro S Delerue-Matos C | | 0，，： | 1 |
| 19 | A lattice dynamical investigation of the raman and the infrared frequencies of the cubic A2Sn207 pyrochlores 显示文摘 | GUPTA H C BROWN S RANI N | 2001 | International Journal of Inorganic Materials2001，3，7： | 1 |
| 20 | A theory of economic development显示文摘 | Ranis G Fei J C H | 1961 | The American Economic Review1961，51，4： | 1 |
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