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| 1 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 2 | Hydrodynamics of trickle bed reactors:experiments and CFD modeling显示文摘 | Gunjal P R Kashid M N Ranade V V Chaudhuri R V | | 0，，16： | 1 |
| 3 | Reversal of phototaxis in the larvae of Polydora pulchra Carazzi (Polychaeta,Spionidae)显示文摘 | RANADE M R | 1957 | Nature1957，179，： | 1 |
| 4 | Evaluating EMMS model for simulating high solid flux risers显示文摘 | Naren P R Lali A M Ranade V V | | 0，，8： | 1 |
| 5 | Hy- drodynamics of bubble column reactors at high gas velocity: experiments and computational fluid dynamics (CFD) sim- ulations 显示文摘 | RAMPURE M R KULKARNI A A RANADE V V | 2007 | Industrial & Engineering Chemistry Research2007，46，25： | 1 |
| 6 | Hydrodynamics of bubble column reactors at high gas velocity:experiments and computational fluid dynamics(CFD)simulations显示文摘 | Rampure M R Kulkarni A A Ranade V V | | 0，，25： | 1 |
| 7 | Styrenic block copolymers for biomaterial and drug delivery application 显示文摘 | RANADE S V RICHARD R E HELMUS M N | 2005 | Acta Siomater2005，，1： | 1 |
| 8 | Energetics of Nanocrystalline TiO2显示文摘 | RANADE M R NAVROTSKY A ZHANG H Z | 2002 | Proceedings of the National Academy of Sciences of the United States of America2002，99，2： | 1 |
| 9 | Hydrody-namic of bubble column reactors at high gas velocity:experiments and computational fluid dynamics(CFD) simulations显示文摘 | RAMPURE M R KULKRNI A A Ranade V V | | 0，，25： | 1 |
| 10 | Hydrodynamics of bubble column reactors at high gas velocity: Experiments and computational fluid dynamics (CFD) simulations显示文摘 | Rampure M R Kulkarni A A Ranade V V | 2007 | Ind Eng Chem Res2007，46，25： | 1 |
| 11 | Hydrodynamics of bubble column reactors at high gas velocity: experiments and computational fluid dynamics (CFD) simulations显示文摘 | Rarnpure M R Kulkarni A A Ranade V V | 2007 | Industrial & Engineering Chemistry Research2007，46，25： | 1 |
| 12 | Hydrodynamics of bub- ble column reactors at high gas velocity:Experiments and computa- tional fluid dynamics (CFD) simulations显示文摘 | Rampure M R Kulkami A A Ranade V V | 2007 | Ind Eng Chem Res2007，46，25： | 1 |
| 13 | Glimpses of antimicrobial activity of fungi from world 显示文摘 | Ranadive K R Belsare M H Deokule S S | 2013 | Journal on New Biological Reports2013，2，2： | 1 |
| 14 | Energetics of Nanocrystalline TiO2 显示文摘 | Ranade M R Navrotsky A Zhang H Z | 2002 | Proceedings of the National Academy of Sciences2002，99，2： | 1 |
| 15 | Physical characterization of controlled release of paclitaxel from the TAXUS Express2 drugeluting stent显示文摘 | Ranade S V Miller K M Richard R E | 2004 | J Biomed Mater Res A2004，71，4： | 1 |
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