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| 1 | 热处理对直链淀粉扩增、蜡性及正常玉米淀粉物理性质和酶解率的影响显示文摘对直链淀粉扩增(ae)、蜡性(wx)及正常玉米淀粉经热处理(autoclaving)后,其物理性质和酶解率的变化进行研究。淀粉经热处理后,除蜡性淀粉其峰值粘度增加外,所有淀粉的峰值粘度降低,且糊化温度提高。热处理增加扩增淀粉的热焓(ΔH),但降低蜡性淀粉的ΔH;同时对正常玉米淀粉的ΔH几乎无影响。热处理使蜡性和正常玉米淀粉的硬度和粘结力增加,但使扩增淀粉的硬度和粘结力降低;同时使所有淀粉的弹性降低。热处理后除蜡性淀粉其溶解率提高外,所有淀粉的膨胀率和溶解率降低。热处理降低所有淀粉的透光率和酶解率。 | 刘惠君 Lawrence Ramsden Harold Corke | 1998 | 中国粮油学报1998，13，4： | 17 |
| 2 | 芋头在加工食品中的应用显示文摘芋头是天南星科中最重要的可食品种,具有悠久的栽培历史。2,000多年来,亚洲、非洲和波利尼西亚等地区的人,一直把它当作一种农作物。芋头遍布于热带地区,现在栽培的品种可能有数千种,大致可归纳为一个种属两个亚种,即生长1个中央大块茎的“dasheen”型和生长成很多小球茎的“eddoe”型。 芋头是一种淀粉质块茎,叶子简单宽阔而叶柄长。尽管很多芋头品种的外表、风味和质地均不一致,但其某些特征仍是相似的,如外表多毛。 | 蒋高松 Lawrence Ramsden Harold Corke | 1998 | 中国食品工业1998，，12： | 10 |
| 3 | The interplay of aging,genetics and environmental factors in the pathogenesis of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is characterized by dopaminergic neuronal loss in the substantia nigra pars compacta and intracellular inclusions called Lewy bodies(LB).During the course of disease,misfoldedα-synuclein,the major constituent of LB,spreads to different regions of the brain in a prion-like fashion,giving rise to successive non-motor and motor symptoms.Etiology is likely multifactorial,and involves interplay among aging,genetic susceptibility and environmental factors.Main body:The prevalence of PD rises exponentially with age,and aging is associated with impairment of cellular pathways which increases susceptibility of dopaminergic neurons to cell death.However,the majority of those over the age of 80 do not have PD,thus other factors in addition to aging are needed to cause disease.Discovery of neurotoxins which can result in parkinsonism led to efforts in identifying environmental factors which may influence PD risk.Nevertheless,the causality of most environmental factors is not conclusively established,and alternative explanations such as reverse causality and recall bias cannot be excluded.The lack of geographic clusters and conjugal cases also go against environmental toxins as a major cause of PD.Rare mutations as well as common variants in genes such as SNCA,LRRK2 and GBA are associated with risk of PD,but Mendelian causes collectively only account for 5%of PD and common polymorphisms are associated with small increase in PD risk.Heritability of PD has been estimated to be around 30%.Thus,aging,genetics and environmental factors each alone is rarely sufficient to cause PD for most patients.Conclusion:PD is a multifactorial disorder involving interplay of aging,genetics and environmental factors.This has implications on the development of appropriate animal models of PD which take all these factors into account.Common converging pathways likely include mitochondrial dysfunction,impaired autophagy,oxidative stress and neuroinflammation,which are associated with the accumulation and spread of misfoldedα-synuclein and neurodegeneration.Understanding the mechanisms involved in the initiation and progression of PD may lead to potential therapeutic targets to prevent PD or modify its course. | Shirley Yin-Yu Pang Philip Wing-Lok Ho Hui-Fang Liu Chi-Ting Leung Lingfei Li Eunice Eun Seo Chang David Boyer Ramsden Shu-Leong Ho | 2019 | Translational Neurodegeneration2019，8，1： | 5 |
| 4 | Stigmatic exudate in the Annonaceae:Pollinator reward,pollen germination medium or extragynoecial compitum?显示文摘Although 'dry-type' stigmas are widely regarded as ancestral in angiosperms, the early-divergent family Annonaceae has copious stigmatic exudate. We evaluate three putative functions for this exudate: as a nutritive reward for pollinators; as a pollen germination medium; and as an extragynoecial compitum that enables pollen tube growth between carpels. Stigmatic exudate is fructose dominated(72.2%), but with high levels of glucose and sucrose; the dominance of hexose sugars and the diversity of amino acids observed, including many that are essential for insects, support a nutritive role for pollinators. Sugar concentration in pre-receptive flowers is high(28.2%), falling during the peak period of stigmatic receptivity(17.4%), and then rising again toward the end of the pistillate phase(32.9%). Pollen germination was highest in sugar concentrations <20%. Sugar concentrations during the peak pistillate phase therefore provide optimal osmolarity for pollen hydration and germination; subsequent changes in sugar concentration during anthesis reinforce protogyny(in which carpels mature before stamens), enabling the retention of concentrated exudate into the staminate phase as a pollinator food reward without the possibility of pollen germination. Intercarpellary growth of pollen tubes was confirmed: the exudate therefore also functions as a suprastylar extragynoecial compitum, overcoming the limitations of apocarpy. | Jenny Y.Y.Lau Chun-Chiu Pang Lawrence Ramsden Richard M.K.Saunders | 2017 | Journal of Integrative Plant Biology2017，59，12： | 3 |
| 5 | Mitochondrial neuronal uncoupling proteins:a target for potential disease-modification in Parkinson’s disease Philip显示文摘This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in the converging pathogenic processes involved in Parkinson’s disease(PD).Mitochondria provide cellular energy in the form of ATP via oxidative phosphorylation,but as an integral part of this process,superoxides and other reactive oxygen species are also produced.Excessive free radical production contributes to oxidative stress.Cells have evolved to handle such stress via various endogenous anti-oxidant proteins.One such family of proteins is the mitochondrial uncoupling proteins(UCPs),which are anion carriers located in the mitochondrial inner membrane.There are five known homologues(UCP1 to 5),of which UCP4 and 5 are predominantly expressed in neural cells.In a series of previous publications,we have shown how these neuronal UCPs respond to 1-methyl-4-phenylpyridinium(MPP+;toxic metabolite of MPTP)and dopamine-induced toxicity to alleviate neuronal cell death by preserving ATP levels and mitochondrial membrane potential,and reducing oxidative stress.We also showed how their expression can be influenced by nuclear factor kappa-B(NF-B)signaling pathway specifically in UCP4.Furthermore,we previously reported an interesting link between PD and metabolic processes through the protective effects of leptin(hormone produced by adipocytes)acting via UCP2 against MPP+-induced toxicity.There is increasing evidence that these endogenous neuronal UCPs can play a vital role to protect neurons against various pathogenic stresses including those associated with PD.Their expression,which can be induced,may well be a potential therapeutic target for various drugs to alleviate the harmful effects of pathogenic processes in PD and hence modify the progression of this disease. | WL Ho Jessica WM Ho Hui-Fang Liu Danny HF So Zero HM Tse Koon-Ho Chan David B Ramsden Shu-Leong Ho | 2012 | Translational Neurodegeneration2012，1，1： | 3 |
| 6 | LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson’s disease显示文摘Mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA) represent two most common genetic causes of Parkinson’s disease (PD). Both genes are important in the autophagic-lysosomal pathway (ALP), defects of which are associated with α-synuclein (α-syn) accumulation. LRRK2 regulates macroautophagy via activation of the mitogen activated protein kinase/extracellular signal regulated protein kinase (MAPK/ERK) kinase (MEK) and the calcium-dependent adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathways. Phosphorylation of Rab GTPases by LRRK2 regulates lysosomal homeostasis and endosomal trafficking. Mutant LRRK2 impairs chaperone-mediated autophagy, resulting in α-syn binding and oligomerization on lysosomal membranes. Mutations in GBA reduce glucocerebrosidase (GCase) activity, leading to glucosylceramide accumulation, α-syn aggregation and broad autophagic abnormalities. LRRK2 and GBA influence each other: GCase activity is reduced in LRRK2 mutant cells, and LRRK2 kinase inhibition can alter GCase activity in GBA mutant cells. Clinically, LRRK2 G2019S mutation seems to modify the effects of GBA mutation, resulting in milder symptoms than those resulting from GBA mutation alone. However, dual mutation carriers have an increased risk of PD and earlier age of onset compared with single mutation carriers, suggesting an additive deleterious effect on the initiation of PD pathogenic processes. Crosstalk between LRRK2 and GBA in PD exists, but its exact mechanism is unclear. Drugs that inhibit LRRK2 kinase or activate GCase are showing efficacy in pre-clinical models. Since LRRK2 kinase and GCase activities are also altered in idiopathic PD (iPD), it remains to be seen if these drugs will be useful in disease modification of iPD. | Shirley Yin-Yu Pang Rachel Cheuk Nam Lo Philip Wing-Lok Ho Hui-Fang Liu Eunice Eun Seo Chang Chi-Ting Leung Yasine Malki Zoe Yuen-Kiu Choi Wing Yan Wong Michelle Hiu-Wai Kung David Boyer Ramsden Shu-Leong Ho | 2022 | Translational Neurodegeneration2022，11，1： | 2 |
| 7 | 爪极永磁同步电动机脉动转矩的计算显示文摘脉动转矩的准确计算是爪极永磁同步电动机优化设计的基本前提之一 .在电机内磁场三维有限元数值分析的基础上 ,采用虚位移和麦克斯韦张量两种不同的方法计算了电机的脉动转矩 .计算数据和实验结果符合得较好 ,证实了磁场分析方法的正确性 . | 郭有光 朱建国 V.S. Ramsden 王雪帆 | 2000 | 华中理工大学学报2000，28，8： | 2 |
| 8 | Physical properties of cross-linked and acetylated normal and waxy rice starch显示文摘 | Liu H J Ramsden L Corke H | 1999 | Starch/Strke1999，51，7： | 1 |
| 9 | The nature of suicide:Science and the selfdest ructive animal显示文摘 | Ramsden E Wilson D | | 0，，01： | 1 |
| 10 | Physical properties of cross-linked and acetylated normal and waxy rice starch显示文摘 | LIU H J RAMSDEN L CORKE H | 1999 | Starch1999，51，7： | 1 |
| 11 | Modelling uncertainty ingreenhouse gas emissions from UK agriculture at the farmlevel显示文摘 | Gibbons J M Ramsden S J Blake A | 2006 | Agriculture Ecosystems and Environment2006，112，4： | 1 |
| 12 | A performance indicator of teaching quality in ihigher education: The course experience questionnaire 显示文摘 | Ramsden P | 1991 | Studies in Higher Education1991，2，： | 1 |
| 13 | Cochlear implantation in children with syndromic deafness显示文摘 | Stephen J. Broomfield Iain A. Bruce Lise Henderson Richard T. Ramsden Kevin M.J. Green | 2013 | International Journal of Pediatric Otorhinolaryngology2013，，8： | 1 |
| 14 | Soft tissue complications after small incision pediatric cochlear implantation显示文摘 | Davids T Ramsden J Gordon K | 2009 | Laryngoscope2009，119，： | 1 |
| 15 | Automated contour mapping using triangular element data structures and an interpolant over each irregular triangular domain显示文摘 | Gold C M Charters T D Ramsden J | 1977 | ACM SIGGRAPH Computer Graphics1977，11，2： | 1 |
| 16 | Generation an in vitro-in vivo correlation for metabolisn and liver enrichment of a hepatitis a virus drug, felden previr, using a rat hepatocyte model 显示文摘 | Ramsden D Twedie D J St George R | 2014 | Drug Metab Diapos2014，42，3： | 1 |
| 17 | Practice guidelines for the molecular analysis of Prader-Willi and Angelman syndromes显示文摘 | Ramsden SC Clayton-Smith J Birch R | 2010 | BMC Med Genet2010，11，： | 1 |
| 18 | Membrane dynamics and spatial distribution of Salmonella-containing vaeuoles显示文摘 | Ramsden AE Holden DW Mota LJ | 2007 | Trends Microbiol2007，15，11： | 1 |
| 19 | Physical properties and enzymat- ic digestibility of acetylated ae, wx and normal maize starch 显示文摘 | Liu H Ramsden L Corke H | 1997 | Carbohydrate Polymers1997，34，： | 1 |
| 20 | 查看详情显示文摘 | Ramsden W | | 0，，： | 1 |
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