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| 1 | Metabolic syndrome as a risk factor for gallstone disease显示文摘AIM: To establish an association between the presence of metabolic syndrome and the development of gallstone disease.METHOIDS: We carried out a cross-sectional study in a check-up unit in a university hospital in Mexico City. We enrolled 245 subjects, comprising 65 subjects with gallstones (36 women, 29 men) and 180 controls (79women and 101 men without gallstones). Body mass index, waist circumference, blood pressure, plasma insulin, and serum lipids and lipoproteins levels were measured. Insulin resistance was calculated by homeostasis model assessment. Unconditional logistic regressionanalysis (univariate and multivariate) was used to calculate the risk of gallstone disease associated with the presence of at least three of the criteria (Adult Treatment Panel Ⅲ). Analyses were adjusted for age and sex.RESULTS: Among 245 subjects, metabolic syndrome was present in 40% of gallstone disease subjects, compared with 17.2% of the controls, adjusted by age and gender (odds ratio (OR) = 2.79; 95%CI, 1.46-5.33; P = 0.002),a dose-dependent effect was observed with each component of metabolic syndrome (OR = 2.36, 95%CI, 0.72-7.71;P = 0.16 with one component and OR = 5.54, 95%CI,1.35-22.74; P = 0.02 with four components of metabolic syndrome). Homeostasis model assessment was significantly associated with gallstone disease (adjusted OR = 2.25;95%CI, 1.08-4.69; P = 0.03).CONCLUSION: We conclude that as for cardiovascular disease and diabetes mellitus, gallstone disease appears to be strongly associated with metabolic syndrome. | Nahum Méndez-Sánchez Norberto C. Chavez-Tapia Daniel Motola-Kuba Karla Sanchez-Lara Guadalupe Ponciano-Rodríguez Héctor Baptista Martha H. Ramos Misael Uribe | 2005 | World Journal of Gastroenterology2005，11，11： | 32 |
| 2 | 国际胃袖状切除专家共识:基于>12000手术病例的最佳操作指南显示文摘腹腔镜胃袖状切除术(1aparoscopic sleeve gastrectomy,LSG)系相对较新的减重手术方式。因其操作相对简单、治疗肥胖合并疾病及减重效果明显,逐步得以广泛接受。目前美国代谢与减重手术协会将其推荐为肥胖症治疗的单独标准术式。2011年3月25~26日, | 苏远涛 徐安安 朱江帆 Diaz AA Arvidsson D Baker RS Basso N Bellanger D Boza C El Mourad H France M Gagner M Galvao-Neto M Higa KD Himpens J Hutchinson CM Jacobs M Jorgensen JO Jossart G Lakdawala M Nguyen NT Nocca D Prager G Pomp A Ramos AC Rosenthal RJ Shah S Vix M Wittgrove A Zundel N | 2013 | 中国微创外科杂志2013，13，9： | 12 |
| 3 | Serum leptin levels and insulin resistance are associated with gallstone disease in overweight subjects显示文摘AIM: To establish an association between the serum leptin levels and the development of gallstone disease (GD).METHODS: We carried out a non-matched case-controlled study in a university hospital in Mexico City. Two hundred and eighty-seven subjects were included: 97 cases with gallstones and 190 controls. Body mass index (BMI), fasting plasma leptin, insulin, serum lipid, and lipoprotein levels were measured. Insulin resistance was calculated by homeostasis model assessment (HOMA-IR). Unconditional logistic regression analysis (univariate and multivariate)stratified by BMI was used to calculate the risk of GD.RESULTS: The multivariate conditional regression analysis revealed a model for those patients with BMI <30. The selected variables in the model were HOMA-IR index with OR = 1.31, P= 0.02 and leptin higher than median with OR = 2.11, P= 0.05. In the stratum of BMI ≥30, we did not find a useful model.CONCLUSION: We concluded that insulin resistance and the development of GD appears to be associated with serum leptin levels in subjects with overweight, but not in obese subjects with similar metabolic profiles. | Nahum Méndez-Sánchez Luisa B Bermejo-Martínez Yolanda Vi(n|~)als Norberto C Chavez-Tapia Irina Vander Graff Guadalupe Ponciano-Rodríguez Martha H Ramos Misael Uribe | 2005 | World Journal of Gastroenterology2005，11，39： | 11 |
| 4 | Repression of the Auxin Response Pathway Increases Arabidopsis Susceptibility to Necrotrophic Fungi显示文摘在植物,到 necrotrophic 病原体的抵抗取决于在不同荷尔蒙系统之间的相互影响,例如水杨酸调整的那些酸(SA ) , jasmonic 酸(JA ) ,乙烯,和 abscisic 酸。由 SA 小径发信号的植物生长素的压抑最近被显示贡献抗菌剂抵抗。这里,我们表明表明在刺激植物生长素的 SCF (Skp1CullinF 盒子) ubiquitination 小径展览有缺点的异种 axr1, axr2,和 axr6 的那 Arabidopsis 植物生长素增加的危险性到 necrotrophic 真菌 Plectosphaerella cucumerina 和 Botrytis cinerea。另外,被 SCF-ubiquitin/proteasome 机械通常为移动指向的植物生长素 transcriptional 抑压者 AXR3 的稳定发生在 P 之上。cucumerina 感染。植物生长素运输或 proteasome 功能的药理学抑制各作为在非对待的植物生长素反应异种损害野类型的植物的 necrotroph 抵抗到类似的程度。这些结果建议植物生长素发信号为到 necrotrophic 真菌 P 的抵抗是重要的。cucumerina 和 B。cinerea。SGT1b (编码 HSP90/HSC70 合作女伴的二 Arabidopsis SGT1 基因之一) 在某些抵抗(R) 基因调节到 biotrophic 病原体的植物生长素和 JA 回答和抵抗支持 SCF E3-ubiquitin ligase 建筑群的功能。我们发现 sgt1b 异种对 P 同样抵抗。是的 cucumerina 野类型的植物。相反地, auxin/SCF 发信号异种在到 obligate biotrophic oomycete 的被触发 RPP4 的抵抗是不妥协的, Hyaloperonospora parasitica。因此,在到 oomycetes 的 R 调节基因的抵抗的 SGT1b 的占优势的行动看起来在除帮助 SCF E3-ubiquitin ligases 以外的一个地点。然而, sgt1b axr1 的基因添加在到 H 的危险性的两倍异种。一旦 plantpathogen 相容性被建立, parasitica 建议调停 SCF 的 ubiquitination 贡献限制 biotrophic 病原体殖民。 | Francisco Llorente Paul M usksktt Andrea Sanchez-Vallet Gemma Lopez Brisa Ramos Clara Sanchez-Rodriguez Lucia Jorda Jane Parker Antonio Molina | 2008 | Molecular Plant2008，1，3： | 8 |
| 5 | Understanding plant drought resistance in a Mediterranean coastal sand dune ecosystem:differences between native and exotic invasive species显示文摘Aims Mediterranean coastal dunes are habitats of great conservation interest,with a distinctive and rich flora.In the last century,Acacia spp.,native from Australia,have been introduced in Portugal,with the objective of stabilizing sand dunes,and since have become dominant in numerous sand dune habitats.This invasion process led to the reduction of native plant species richness,changed soil characteristics and modified habitat’s microclimatic char-acteristics.The aim of this research was to typify and compare,in Mediterranean sand dune ecosystems,the ecophysiological responses to drought of Helichrysum italicum and Corema album,two native species,and Acacia longifolia,an exotic invasive spe-cies.We addressed the following specific objectives:(i)to com-pare water relations and water use efficiencies,(ii)to evaluate water stress,(iii)to assess water use strategies and water sources used by plants and(iv)to evaluate the morphological adaptations at leaf and phyllode level.Methods In order to obtain an integrative view of ecophysiological patterns,water relations and performance measuring methods have been applied:predawn(ψPD)and midday(ψMD)water potential,chloro-phyll a fluorescence,oxygen isotopic composition of xylem,rain and groundwater(δ18O)and leaf carbon isotopic discrimination(Δ13C).The leaf characteristics of the three species,as well as the histochemistry of non-glandular trichome cell walls,were also studied to identify morpho-traits related to drought resistance.Important Findings The results support our initial hypothesis:although A.longifolia clearly possesses a degree of resistance to water stress,such ability is provided by a different water strategy,when compared to native species.Natives relied on morphological adaptations to restrict water loss,whereas the invasive species adjusted the water uptake as a way to balance their limited ability of restricting water loss.We corroborate that woody native species(i)have a conservative water-saving strategy and minor seasonal variations relative to invasive species,(ii)use enriched water sources during drought periods,indicating different water sources and root systems com-paring with invasive species and(iii)present drought leaf morpho-functional adaptations related with limiting water loss.Comparing the physiological performance of invasive and native species can offer causal explanations for the relative success of alien plant invasions on sand dunes ecosystems. | Cristina Antunes Ana Júlia Pereira Patrícia Fernandes Margarida Ramos Lia Ascensão Otília Correia Cristina Máguas | 2018 | Journal of Plant Ecology2018，11，1： | 4 |
| 6 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 7 | Sequential extraction of copper, lead, cadmium and zinc in sediments from Ebro River (Spain): relationship with levels detected in earthworms 显示文摘 | RAMOS L GONZALEZ M J HERN ~NDEZ L M | 1999 | Bulletin of Environment Contamination and Toxicology1999，62，： | 1 |
| 8 | Antihypertensive activity of milk fermented by Enterococcus faecalis strains isolated from raw milk显示文摘 | MUGUERZA B RAMOS M SANCHEZ E | 2006 | International Dairy Journal2006，16，： | 1 |
| 9 | Determination of the furaltadone metabolite 5-methylmorpholino-3-amino -9 oxazolidinone (AMOZ) using liquid chromatography coupled to electrospray tandem mass spectrometry during the nitrofuran crisis in Portugal显示文摘 | Barbosa J Ferreira M L Ramos F | 2007 | Accred Qual Assur2007，12，： | 1 |
| 10 | A study on the characteristics of various conductive contaminants accumulated on high voltage insulators显示文摘 | Ramos N G Campillo R M T Naito K | 1993 | IEEE Trans on Power Delivery1993，8，4： | 1 |
| 11 | Substance P up-regulates matrix metalloproteinase-1 and down-regulates collagen in human lung fibroblast显示文摘 | Ramos C Montano M Cisneros J | 2007 | Exp Lung Res2007，33，34： | 1 |
| 12 | A versatile rhodium catalyst for acetalization reactions under mild conditions显示文摘 | Ott G M Ramos T Grand D | 1989 | Tetrahedron Letters1989，30，45： | 1 |
| 13 | 显示文摘 | CALZDA M L MARTIN M J RAMOS P | 1997 | J Phys Chem Solids1997，58，7： | 1 |
| 14 | Optimization of millimeter-wave signal generation through FM-IM conversion in chirped fiber gratings 显示文摘 | Marti J Fuster J M Ramos F | 2000 | Microwave and Optical Technology Letters2000，27，6： | 1 |
| 15 | A study on the char- acteristics of various conductive contaminants accumulated on high voltage insulators显示文摘 | Ramos N G Campillo R M T Naito K | 1993 | IEEE Transactions on Power Deliv- ery1993，8，18： | 1 |
| 16 | Esterification of glycerol with acetic acid over dodecamolybdophosphoric acid encaged in USY zeolite 显示文摘 | Ferreira P Fonseca I M Ramos A M | 2009 | Catalysis Communica- tions2009，10，5： | 1 |
| 17 | Scientific and clinical challenges in sepsis 显示文摘 | Ulloa L Brunner M Ramos L | 2009 | Curr Pharm Des2009，15，16： | 1 |
| 18 | hnmobi- lization of candida rugosa lipase on bentonite modified with benzyhriethylammonium chloride 显示文摘 | RAMOS M D GOMEZ G I G GONZALEZ N S | 2014 | Journal of Molecular Catalysis B : Enzymatic2014，，99： | 1 |
| 19 | Software- defined networking: A comprehensive survey显示文摘 | KREUTZ D RAMOS F M V VERISSIMO P E | 2015 | Proceedings of the IEEE2015，103，1： | 1 |
| 20 | T cell cytokines:animal models显示文摘 | Suzuki M Ramos Barbon D | 2004 | Paediatr Respir Rev2004，5，： | 1 |
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