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1Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome显示文摘We report a case of virus-induced acute respiratory distress syndrome(ARDS) treated with parenteral vitamin C in a patient testing positive for enterovirus/rhinovirus on viral screening. This report outlines the first use of high dose intravenous vitamin C as an interventional therapy for ARDS, resulting from enterovirus/rhinovirus respiratory infection. From very significant preclinical research performed at Virginia Commonwealth Universitywith vitamin C and with the very positive results of a previously performed phase Ⅰ safety trial infusing high dose vitamin C intravenously into patients with severe sepsis, we reasoned that infusing identical dosing to a patient with ARDS from viral infection would be therapeutic. We report here the case of a 20-year-old, previously healthy, female who contracted respiratory enterovirus/rhinovirus infection that led to acute lung injury and rapidly to ARDS. She contracted the infection in central Italy while on an 8-d spring break from college. During a return flight to the United States, she developed increasing dyspnea and hypoxemia that rapidly developed into acute lung injury that led to ARDS. When support with mechanical ventilation failed, extracorporeal membrane oxygenation(ECMO) was initiated. Twelve hours following ECMO initiation, high dose intravenous vitamin C was begun. The patient's recovery was rapid. ECMO and mechanical ventilation were discontinued by day-7 and the patient recovered with no long-term ARDS sequelae. Infusing high dose intravenous vitamin C into this patient with virus-induced ARDS was associated with rapid resolution of lung injury with no evidence of post-ARDS fibroproliferative sequelae. Intravenous vitamin C as a treatment for ARDS may open a new era of therapy for ARDS from many causes.Alpha A Fowler Ⅲ Christin Kim Lawrence Lepler Rajiv Malhotra Orlando Debesa Ramesh Natarajan Bernard J Fisher Aamer Syed Christine DeWilde Anna Priday Vigneshwar Kasirajan 2017World Journal of Critical Care Medicine2017,6,1:9
2Inhibition of Apoptotic Signaling and Neointimal Hyperplasia by Tempol and Nitric Oxide Synthase following Vascular Injury显示文摘Jagadeesha Dammanahalli K Miller Jr Francis J Bhalla Ramesh C 2009Journal of Vascular Research2009,,2:2
3The High-Strain-Rate Response of Alpha-Titanium:Experiments Deformation Mechanisms and Modeling 显示文摘Chichili D R Ramesh K T Hemker K J 1998Acta Mater1998,46,3:1
4The high-strain-rate response of alpha-titanium: Experiments, deformation mechanisms and modeling显示文摘Chichili D R Ramesh K T Hemker K J 1998Acta Materialia1998,46,3:1
5An efficient approach to stochastic Job Shop scheduling: algorithms and empirical investigations显示文摘RAMESH R CARY J M 1990Computers and Industrial Engineering1990,18,2:1
6Properties and crystallization of rare-earth Si-Al-O-N glasses containing mixed trivalent modifiers显示文摘POMEROY M J NESTOR E RAMESH R HAMPSHIRE S 2005Journal of the American Ceramic Society2005,88,4:1
7Carbothermal reduction and nitridation reaction of SiOx and preoxidized SiOx:formation of α-Si3N4 fibers显示文摘RAMESH P D RAO K J 1994J Mater Res1994,9,9:1
8Laser surface engineering of a magnesium alloy with Al and Al2 O3 显示文摘Majumdar J Dutta Ramesh B 2004Suface and Technology2004,179,:1
9Urinary netrin-1 is an early predictive biomarker of acute kidney injury after cardiac surgery显示文摘Ramesh G Krawczeski C D Woo J G 0,,03:1
10Carbon isotopes in kerguelen plume-derived carbonatites: Evidence for recycled inorganic carbon显示文摘Ray J S Ramesh R Pande K 1999Earth and Planetary Science Letters1999,170,:1
11Developmentsin understanding the basis of cooked - rice texture显示文摘Ramesh M Bhattacharya K R Mitchell J R 2000Criti-cal Reviews in Food Science and Nutrition2000,40,6:1
12Synthesis and antibacterial evaluation of 7 coumarins 显示文摘J eyachandran M Ramesh P Muralisankar R 2007Indian J Heteroeyel Chem2007,16,4:1
13A structured framework for efficient problem solving in diagnostic expert systems显示文摘Ramesh T S Shume S K Davis J F 1988Computers and Chemical Engineering1988,910,12:1
14Association between Accounting Performance Measures and Stocks Prices显示文摘ANTHONY J RAMESH K 1992Journal of Accounting and Economics1992,,15:1
15Association between accounting performance measures and stock prices: A test of the life cycle hypothesis 显示文摘Anthony J H Ramesh K 1992Journal of Accounting and Econom- ics1992,15,2:1
16Asdrssment of metabolites and AhR and CYP1A1 mRNA expression subsequent to prenatal exposure to inhaled benzoapyrene显示文摘Wu J Ramesh A Nayyar T 2003Int J Dev Neurosci2003,21,6:1
17Assessment of metabolites and AhR and CYP1 A1 mRNA expression subsequent to prenatal exposure to inhaled benzo (a) pyrene 显示文摘Wu J Ramesh A Nayyar T 2003Int J Dev Neurosci2003,21,6:1
18Isolation of drug-resistant tubercle bacilli in cutaneous tuberculosis显示文摘Ramesh V Murlidhar S Kumar J 2001Pediatr Dermatol2001,18,5:1
19Evaluation of inoculums addition to stimulate in situ bioremediation of oily-sludge-contaminated soil显示文摘Sanjeet M J Jeevan C K Ramesh 2001Applied & Environmental Microbiology2001,67,4:1
20Epitaxial BiFe03 multiferroic thin film heterostructures 显示文摘WANG J NEATON J B ZHENG H NAGARAJAN V OGALE S B LID B VIEHLAND D VAITHYANAATHAN V SCHLOM D G WAGHMARE U V SPALDIN N A RABE K M WUTTIG M RAMESH R 2003Science2003,299,:1
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