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| 1 | Cementomimetics——constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides显示文摘Cementum is the outer-,mineralized-tissue covering the tooth root and an essential part of the system of periodontal tissue that anchors the tooth to the bone. Periodontal disease results from the destructive behavior of the host elicited by an infectious biofilm adhering to the tooth root and left untreated,may lead to tooth loss. We describe a novel protocol for identifying peptide sequences from native proteins with the potential to repair damaged dental tissues by controlling hydroxyapatite biomineralization. Using amelogenin as a case study and a bioinformatics scoring matrix,we identified regions within amelogenin that are shared with a set of hydroxyapatite-binding peptides (HABPs) previously selected by phage display. One 22-amino acid long peptide regions referred to as amelogenin-derived peptide 5 (ADP5) was shown to facilitate cell-free formation of a cementum-like hydroxyapatite mineral layer on demineralized human root dentin that,in turn,supported attachment of periodontal ligament cells in vitro. Our findings have several implications in peptide-assisted mineral formation that mimic biomineralization. By further elaborating the mechanism for protein control over the biomineral formed,we afford new insights into the evolution of protein-mineral interactions. By exploiting small peptide domains of native proteins,our understanding of structure-function relationships of biomineralizing proteins can be extended and these peptides can be utilized to engineer mineral formation. Finally,the cementomimetic layer formed by ADP5 has the potential clinical application to repair diseased root surfaces so as to promote the regeneration of periodontal tissues and thereby reduce the morbidity associated with tooth loss. | Mustafa Gungormus Ersin E Oren Jeremy A Horst Hanson Fong Marketa Hnilova Martha J Somerman Malcolm L Snead Ram Samudrala Candan Tamerler Mehmet Sarikaya | 2012 | International Journal of Oral Science2012，4，2： | 5 |
| 2 | 外科减肥手术后高血压缓解和复发的预测因素显示文摘目前,只有很少量研究涉及外科减肥手术后高血压得到缓解和复发的影响因素,没有可用于预测高血压复发相关因素的信息。该研究的目的是评估在外科减肥手术后第1年和第3年里高血压的缓解情况和复发率,并寻找可能的预测因素。 | Benaiges D Sagué M Flores-Le Roux JA Pedro-Botet J Ramón JM Villatoro M Chillarón JJ Pera M Más A Grande L Goday A 陈云 | 2016 | 中华高血压杂志2016，24，9： | 2 |
| 3 | Developing seedless grapes by embryo rescue显示文摘 | Ramming DW Lu J Lamikanra O | 1995 | Proc-Vitis-SciSymp1995，18，： | 1 |
| 4 | Indirect enzyme-linked immunosorbent assay for the mycotoxin zearalenone显示文摘 | Liu M T Ram B P Hart L P and Pestka J J | 1985 | Appl Environ Microbiol1985，50，2： | 1 |
| 5 | Effect of highpressure treatments on mechanical and functional properties of restructured products from arrowtooth flounder(Atheresthes stomias)显示文摘 | Uresti M R Velazquez G Ramírez J | 2004 | Journal of the Science of Food Agriculture2004，84，： | 1 |
| 6 | The Mi-2/NuRD complex:a critical epigenetic regulator of hematopoietic development,differentiation and cancer显示文摘 | Ramírez J Hagman J | 2009 | Epigenetics2009，4，8： | 1 |
| 7 | Semantic Conflict Resolution Ontology(SCR-OL): An Ontology for Detecting and Resolving Data and Sche-ma-level Semantic Conflicts显示文摘 | Ram S Park J | 2004 | IEEE Transactions on Knowl-edge and Data Engineering2004，16，2： | 1 |
| 8 | Role of the cytokine-inducible SH2 protein ClS in desensitization of STAT5b signaling by eontin- uousgrowth hormone显示文摘 | Ram P A Waxman D J | 2000 | J Biol Chem2000，275，50： | 1 |
| 9 | Shear zone geom etry显示文摘 | Ram say J S | | 0，，： | 1 |
| 10 | Electroless nickel coated short carbon fibres in aluminium matrix composites 显示文摘 | Rams J Urena A Escalera M D Sanchez M | 2007 | Applied Science and Manufacturing2007，38，2： | 1 |
| 11 | Physical parameters reconstruction of a free-free mass-spring system from its spectra显示文摘 | CALDWELL J | 1992 | J SIAM Appl Math1992，152，1： | 1 |
| 12 | Assessment of a palatal approach-anteri-or superior alveolar(P-ASA)nerve block with the wand in pae-diatric dental patients显示文摘 | RAM D KASSIRER J | 2006 | Int J Paediatr Dent2006，16，5： | 1 |
| 13 | Dry sliding wear behaviour of ZE41A magnesium alloy 显示文摘 | LOPEZ A J RODRIGO P TORRES B RAMS J | 2011 | Wear2011，271，1112： | 1 |
| 14 | Transcritical CO2 heat pump systems-exergy analysis incluiding heat transfer and fluid flow effects显示文摘 | J Sarkar Souvik Bhattacharyya M Ram Gopal | | 0，，： | 1 |
| 15 | Race, ethnicity, and sexual orien- tation: still a void in sport and exercise psychology? 显示文摘 | Ram N Starek J Johnson J | 2004 | Jour- nal of Sport and Exercise Psychology2004，，2： | 1 |
| 16 | Blindness in the world 显示文摘 | APPLE DJ RAM J FOSTER A PENG Q | 2000 | Surv Ophthalmol2000，45，： | 1 |
| 17 | Antiotics in periodontaln therapy:advantages and disadvantages显示文摘 | Slots J Rams TE | 1990 | J C1in Periodontol1990，17，7： | 1 |
| 18 | Effect of boron addition on the activity and selectivity of hydrotreating CoMo/Al2O3 catalysts显示文摘 | RAM REZ J CASTILLO P CEDE O L | 1995 | Appl Catal: A1995，132，2： | 1 |
| 19 | Consumer resistance to innova- tions: the marketing problem and its solutions显示文摘 | Ram S Sheth J N | 1989 | Journal of Consumer Marketing1989，6，2： | 1 |
| 20 | Native colonizing species and degraded land restoration in La Gran Sabana显示文摘 | Rosales J Cuenca G Ramírez N | 1997 | Restoration Ecology1997，5，： | 1 |
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