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| 1 | 美国国立神经疾病和卒中研究所-加拿大卒中网血管性认知障碍统一标准显示文摘背景和目的:1/3的个体会罹患卒中和(或)痴呆,而且,除卒中或痴呆外,2倍于此数的人会出现认知障碍。常用的卒中量表并不能评价认知功能,而痴呆的诊断标准则集中在认知障碍的晚期阶段,且在很大程度上偏向Alzheimer病(AD)的诊断。尚缺乏普遍公认的标准用于识别和描述存在认知障碍的个体,尤其是在早期阶段,而且特别是与血管因素有关的认知障碍或血管性认知障碍。方法:美国国立神经疾病和卒中研究所(MINDS)与加拿大卒中网(CSN)召集临床诊断、流行病学、神经心理学、脑影像学、神经病理学、试验模型、生物标记物、遗传学和临床试验方面的研究人员,为血管性认知障碍的描述和研究推荐一些最低限度的常用的临床和研究标准。结果:将这些讨论的结果发表于此。结论:一个统一标准的制定代表着使用、确认和改进过程中的第一步。使用相同的标准将有助于在认知障碍的早期阶段识别患者,使不同的研究具有可比性,并且通过整合知识来加速研究进展的步伐。 | Vladimir Hachinski Costantino Iadecola Ron C.Petersen Monique M.Breteler David L.Nyenhuis Sandra E.Black William J.Powers Charles DeCarli Jose G.Merino Raj N.Kalaria Harry V.Vinters David M.Holtzman Gary A.Rosenberg Martin Dichgans John R.Marler Gabrielle G.Leblanc 李焰生(译) 俞羚(译) 高枚春(译) 张静芳(译) 熊昕丽(译) 邹静(译) 林岩(译) 潘元美(译) | 2007 | 国际脑血管病杂志2007，15，1： | 63 |
| 2 | Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways显示文摘Wogonin is a plant flavonoid compound extracted from Scutellaria baicalensis(Huang-Qin or Chinese skullcap) and has been studied thoroughly by many researchers till date for its anti-viral, anti-oxidant, anti-cancerous and neuro-protective properties. Numerous experiments conducted in vitro and in vivo have demonstrated wogonin's excellent tumor inhibitory properties. The anticancer mechanism of wogonin has been ascribed to modulation of various cell signaling pathways, including serine-threonine kinase Akt(also known as protein kinase B) and AMP-activated protein kinase(AMPK) pathways, p53-dependent/independent apoptosis, and inhibition of telomerase activity. Furthermore, wogonin also decreases DNA adduct formation with a carcinogenic compound 2-Aminofluorene and inhibits growth of drug resistant malignant cells and their migration and metastasis, without any side effects. Recently, newly synthesized wogonin derivatives have been developed with impressive anti-tumor activity. This review is the succinct appraisal of the pertinent articles on the mechanisms of anti-tumor properties of wogonin. We also summarize the potential of wogonin and its derivatives used alone or as an adjunct therapy for cancer treatment. Furthermore, pharmacokinetics and side effects of wogonin and its analogues have also been discussed. | Do Luong Huynh Neelesh Sharma Amit Kumar Singh Simrinder Singh Sodhi ZHANG Jiao-Jiao Raj Kumar Mongre Mrinmoy Ghosh Nameun Kim Yang Ho Park Dong Kee Jeong | 2017 | Chinese Journal of Natural Medicines2017，15，1： | 32 |
| 3 | Soil-Plant-Microbe Interactions in Stressed Agriculture Management:A Review显示文摘The expected rise in temperature and decreased precipitation owing to climate change and unabated anthropogenic activities add complexity and uncertainty to agro-industry. The impact of soil nutrient imbalance, mismanaged use of chemicals, high temperature,flood or drought, soil salinity, and heavy metal pollutions, with regard to food security, is increasingly being explored worldwide. This review describes the role of soil-plant-microbe interactions along with organic manure in solving stressed agriculture problems. Beneficial microbes associated with plants are known to stimulate plant growth and enhance plant resistance to biotic(diseases) and abiotic(salinity, drought, pollutions, etc.) stresses. The plant growth-promoting rhizobacteria(PGPR) and mycorrhizae, a key component of soil microbiota, could play vital roles in the maintenance of plant fitness and soil health under stressed environments. The application of organic manure as a soil conditioner to stressed soils along with suitable microbial strains could further enhance the plant-microbe associations and increase the crop yield. A combination of plant, stress-tolerant microbe, and organic amendment represents the tripartite association to offer a favourable environment to the proliferation of beneficial rhizosphere microbes that in turn enhance the plant growth performance in disturbed agro-ecosystem. Agriculture land use patterns with the proper exploitation of plant-microbe associations, with compatible beneficial microbial agents, could be one of the most effective strategies in the management of the concerned agriculture lands owing to climate change resilience. However, the association of such microbes with plants for stressed agriculture management still needs to be explored in greater depth. | Shobhit Raj VIMAL Jay Shankar SINGH Naveen Kumar ARORA Surendra SINGH | 2017 | Pedosphere2017，27，2： | 24 |
| 4 | 1971-2009年珠穆朗玛峰地区尼泊尔境内气候变化显示文摘利用珠穆朗玛峰南坡尼泊尔境内(科西河流域)的10个气象站1971-2009年月平均气温、月平均最高、最低气温和逐月降水资料,采用线性趋势、Sen斜率估计、Mann-Kendall等方法分析区域气候变化状况及其时空特征,并与珠穆朗玛峰北坡地区气候进行比较,分析了珠穆朗玛峰地区气候变化的特征与趋势。结果表明:(1)1971-2009年间,珠穆朗玛峰南坡年平均气温为20.0℃,线性升温率为0.25℃/10a,与北坡主要受年平均最低气温影响相反,增幅主要受年平均最高气温升高的影响,并且在1974年及1992年间出现两次显著增温,增温特别明显的月份为2月和9月;(2)该地区降水变化的局地性较强,近40年间年平均降水量为1729.01mm,年平均降水量以每年约4.27mm的线性增幅有所增加,但并不显著,且降水月变化和季变化特征均不明显;(3)由于珠穆朗玛峰南坡受到季风带来暖湿气流和喜马拉雅山阻挡的双重影响,珠峰南坡的年平均降水量远高于北坡;(4)珠穆朗玛峰南坡气温变暖的海拔依赖性并不明显,且南坡地区的变暖趋势并没有北坡变暖趋势明显。 | 祁威 张镱锂 高俊刚 杨续超 刘林山 Narendra Raj KHANAL | 2013 | 地理学报2013，68，1： | 21 |
| 5 | Congenital choledochal cysts in adults:twenty-five-year experience显示文摘背景 Choledochal 包囊在西方的国家是稀罕的。共存的 hepatobiliary 疾病的相对高的发生增加 choledochal 包囊的外科的管理的困难。这里,我们在有先天的 choledochal 包囊的 122 个病人的临床的数据从 1981 ~ 2006 承认了的 122 中国 adults.Methods 分析先天的胆汁管包囊的诊断和治疗,导致推迟的诊断是在大多数情况中的临床的症状是的 analyzed.Results nonspecific。61 个病人(50%) 有共存的 pancreatobiliary 疾病。在 122 个病人之中, 119 个病人经历了超声的检查; ERCP/MRCP 在 102 种情况中在 63 种情况和 CT 中被执行。反常 pancreatobiliary 管连接在 48 个病人被发现。十六个病人在胆汁管有恶意的损害,从经历了包括 cystenterostomy 或 cystojejunostomy 的各种各样的操作的不完全的 choledochal 包囊在他们中的 11 个产生。处于胆汁管的恶意率经历了不完全的包囊切除术和完全的包囊切除术的病人之间有重要差别(迟平方测试, P= 0.000;机会比率, 7.800;95 % 信心间隔, 2.450 ~ 24.836 ).Conclusions ERCP, CT 和 MRCP 在疾病的分类证明了他们的大价值。有 Roux-en-Y hepaticojejunostomy 的包囊切除与类型或类型包囊为病人被推荐为选择的治疗。为有周期性的胆管炎的类型包囊(Caroli 的疾病) ,肝移植应该被考虑。 | LIU Ying-bin WANG Jian-wei Khagendra Raj Devkota JI Zhen-ling LI Jiang-tao WANG Xu-an MA Xiao-ming CAI Wei-long KONG Ying CAO Li-ping PENG Shu-you | 2007 | Chinese Medical Journal2007，，16： | 19 |
| 6 | 同期化放疗在局部晚期鼻咽癌治疗中的作用:一项关于Ⅲ期随机对照试验的荟萃分析显示文摘目的本项荟萃分析的主要目的是通过比较鼻咽癌病人同期化放疗与单纯放疗的总生存、疾病的局部控制率及远处转移率的差异从而确定同期化放疗在局部晚期鼻咽癌中的作用。次要目的是比较鼻咽癌病人同期化放疗和同期化放疗联合辅助化疗与单纯放疗的生存差别。病人和方法按照预先设计荟萃分析的方案,选择已发表的Ⅲ期随机对照临床研究。临床研究的入选标准包括:①所有入组的鼻咽癌病人随机分为单纯放疗组或同期化放疗组;②临床研究中的病人必须是经组织学证实为鼻咽癌(WHO分型Ⅰ~Ⅲ型);③所有入组的病人都必须接受原发病灶至少为64Gy的足够剂量的常规分割放疗。结果本项荟萃分析共包括了7个临床研究中的1630名病人。与单纯放疗相比,同期化放疗组病人的2年、3年和5年总生存风险比值分别为0.54(95%置信区间0.41~0.70)、0.54(95%置信区间0.37~0.78)和0.49(95%置信区间0.28~0.84),而其相应的2年、3年和5年绝对生存获益分别为9%、10%和13%。同期化放疗组与单纯放疗组的局部复发率及远处转移率也是可比的,并且同期化放疗组可见到明显的生存获益,其5年局部复发率及远处转移率的风险比值分别为0.49(95%置信区间0.30~0.78)和0.59(95%置信区间0.46~0.76)。同期化放疗加辅助化疗与单纯放疗对比的生存获益(包括总生存、局部控制率和远处转移率)比单用同期化放疗与单纯放疗对比的生存获益有所改善,但这种改善差异没有统计学意义。结论本研究结果表明同期化放疗是改善鼻咽癌患者总生存最有效的方法。辅助化疗的确切作用尚不是非常明确,还需要进行更多的研究明确其作用。 | Bijesh Raj Ghimire 林立平 郭颖 张力 | 2007 | 循证医学2007，7，3： | 18 |
| 7 | 压水堆熔融物堆内滞留策略:历史回顾与研究展望显示文摘本文对广泛应用于第三代压水堆的严重事故缓解措施——熔融物堆内滞留(IVR)进行了历史回顾。IVR策略最早源自于第二代反应堆Lovissa VVER-440的改进设计,以应对堆芯熔化事故。随后,IVR策略被应用于许多新设计的反应堆,如西屋的AP1000、韩国的APR1400以及中国的先进压水堆CAP1400和华龙一号。对IVR策略有效性影响最大的因素分别为堆内堆芯熔化进程、熔融物加载于压力容器壁面的热流密度和压力容器外部冷却。对于堆芯熔化进程,过去人们一直仅关注压力容器下腔室内熔池的换热行为。但通过回顾与分析,本文认为堆内的其他现象,如堆芯的降级和迁移、碎片床的形成及其可冷却性以及熔池的动态形成过程等,可能也会对熔池的最终状态及其作用于下封头的热负荷产生影响。通过对相关研究的回顾,本文希望找出IVR策略的研究中有待完善的部分,并据目前发展水平提出未来IVR研究的需求。 | 马卫民 元一单 Bal Raj Sehgal | 2016 | Engineering2016，2，1： | 14 |
| 8 | Projected drought conditions in Northwest China with CMIP6 models under combined SSPs and RCPs for 2015—2099显示文摘Northwest China is one of the most arid regions in the world and has experienced intriguing climate warming and humidification.Nonetheless,future climate conditions in Northwest China still remain uncertain.In this study,we applied an ensemble of the 12 latest model simulations of the Coupled Model Intercomparison Project Phase 6(CMIP6)to assess future drought conditions until 2099 in Northwest China,as inferred from the Palmer Drought Severity Index(PDSI).Future drought conditions were projected under three climate change scenarios through the combination of shared socioeconomic pathways(SSPs)and representative concentration pathways(RCPs),namely,SSP126(SSP1+RCP2.6,a green development pathway),SSP245(SSP2+RCP4.5,an intermediate development pathway),and SSP585(SSP5+RCP8.5,a high development pathway).For 2015-2099,drought severity showed no trend under SSP126,in contrast,for the SSP245 and SSP585 scenarios,a rapid increase during 2015-2099 was observed,especially under SSP585.We also found that the drought frequency in Northwest China under SSP585 was generally lower than that under SSP126 and SSP245,although the drought duration under SSP585 tended to be longer.These findings suggest the green development pathway in drought mitigation and adaptation strategies in Northwest China,an arid and agricultural region along the Silk Road. | LI Su-Yuan MIAO Li-Juan JIANG Zhi-Hong WANG Guo-Jie GNYAWALI Kaushal Raj ZHANG Jing ZHANG Hui FANG Ke HE Yu LI Chun | 2020 | Advances in Climate Change Research2020，11，3： | 14 |
| 9 | Phytochemical and anti-bacterial activity of epidermal glands extract of Christella parasitica (L.) H. Lev.显示文摘Objective:To study the morphology,biochemistry and bioactivity of the epidermal glands of the glandular morphotype of Christella parasitica(C.parasitica)(L.) H.Lev.Methods: Morphological studies on epidermal glands were earned out by using light microscope and scanning electron microscope.To prepare the extract,the shade-dried fronds of glandular morphotype were soaked in acetone.For antibacterial studies paper disc method was followed by using various pathogenic bacteria.Results:Detailed micromorphological,phytochemical and bioactivity studies on a medicinal fern C.parasitica(L.) H.Lev.showed its inlraspecific variation in antibacterial activity.The presence or absence of the epidermal glands was the key factor for antibacterial activity in the morphovariants of this species.The epidermal glands were orange-coloured,stalked and elongated ones of about 84.2μm×45μm,and distributed on the undersurface of cosla,coslules and veins in croziers,young and mature leaves.Frequency of glands varied from 15/cm on costa in mature leaves to 140/cm on costules in croziers.The acetone extract of the glands showed antibacterial activities and also toxic effect against mosquito larvae and tadpoles of frog.Preliminary phytochemical analysis and HPLC studies of the gland extract showed the presence of various kinds of terpenoids,alkaloids,tannins,saponins and flavonoids in it.Conclusions:The present study shows that epidermal glands of the glandular morphotype of C. parasitica(L.) H.Lev.have several bioactive compounds and such rare moiphovariant should be conserved in nature.The next step is to isolate the pure compounds and to screen the bioactivity of individual compounds of the epidermal glands. | Paul Raj K Irudayaraj V Johnson M Patric Raja D | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，1： | 14 |
| 10 | 高PM2.5地区呼吸系统疾病发病率流行病学调查显示文摘目的探讨高PM2.5地区居民呼吸系统疾病发病率情况。方法采取随机抽样方法,廊坊市区、呼和浩特市区常住居民共3564例填写呼吸系统流行病学调查表,统计并比较两地市区居民2008年1月1日至2016年12月30日呼吸系统疾病发病率、症状发生率。在廊坊市区被调查者中随机抽取200例填写2012—2016年每年度呼吸系统流行病学调查表,并统计年均PM2.5浓度,探讨呼吸系统疾病和PM2.5浓度的相关性。结果廊坊市年均PM2.5浓度、空气质量指数明显高于呼和浩特市区(P值均〈0.05)。廊坊市区居民鼻炎、鼻敏感、慢性咽炎、上呼吸道感染、鼻窦炎、支气管炎、支气管哮喘、慢性阻塞性肺疾病(COPD)、肺炎、呼吸系统肿瘤、间质性肺病发病率均高于呼和浩特市区居民(P值均〈0.05);廊坊市区居民咳嗽、咳痰、喘息气促、咽部不适、鼻塞、喉咙痛、喘鸣、呼吸困难发生率高于呼和浩特市区居民(P值均〈0.05)。PM2.5浓度与鼻炎、慢性咽炎、上呼吸道感染、支气管炎、支气管哮喘呈正相关(P值均≤0.05)。结论高PM2.5地区鼻炎、鼻敏感、慢性咽炎、上呼吸道感染、鼻窦炎、支气管炎、支气管哮喘、COPD、肺炎、呼吸系统肿瘤、间质性肺病的发病率较高;高PM2.5地区居民更易发生咳嗽、咳痰、喘息气促、咽部不适、鼻塞、喉咙痛、喘鸣、呼吸困难。 | 高菲 边毓尧 郭文有 修明文 刘永纯 陈光远 Nishant Raj Pandey | 2018 | 国际呼吸杂志2018，38，18： | 13 |
| 11 | 慢性肾脏病中的炎症和动脉硬化:慢性肾功能不全队列研究中的发现显示文摘慢性肾脏病(chronic kidney disease,CKD)和动脉硬化程度与心血管病发病率和死亡率增加相关。目前认为炎症在动脉硬化发展中发挥作用,而CKD被认为是一种促炎症反应的状态。CKD患者的动脉僵硬度增加,横断面数据提示CKD中增多的炎症标志物与较高动脉僵硬度值相关。 | Peyster E Chen J Feldman HI Go AS Gupta J Mitra N Pan Q Porter A Rahman M Raj D Reilly M Wing MR Yang W Townsend RR 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，11： | 12 |
| 12 | Anti-diabetic effects of Caulerpa lentillifera:stimulation of insulin secretion in pancreatic β-cells and enhancement of glucose uptake in adipocytes显示文摘Objective:To evaluate anti-diabetic effect of Caulrpa kntillifera(C.lentillifera).Methods:The inhibitory effect of C.lentillifera extract on dipeptidyl peptidase-IV and a-glucosidase enzyme was measured in a cell free system.Then,interleukin-1βand interferon-γinduced cell death and insulin secretion were measured in rat insulinoma(RIN)cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and ELISA kit,respectively.Glucose uptake and glucose transporter expression were measured by fluorometry and western blotting,using 3T3-Ll adipocytes.Results:C.lentillifera extract significantly decreased dipeptidyl peptidase-IV and a-glucosidase enzyme activities,and effectively inhibited cell death and iNOS expression in interleukin-1βand interfcron-γinduced RIK cells.Furthermore,C.lntillifera extract significantly enhanced insulin secretion in RTN cells and glucose transporter expression and glucose uptake in 3T3-L1adipocytes.Conclusions:Thus,our results suggest that C.lentillifera could be used as a potential antidiabetic agenl. | Bhesh Raj Sharma Dong Young Rhyu | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，7： | 12 |
| 13 | Effect of preoperative biliary drainage on outcome of classical pancreaticoduodenectomy显示文摘AIM: To investigate the role of preoperative biliary drainage (PBD) in the outcome of classical pancreaticodu odenectomy. METHODS: A 10-year retrospective data analysis was performed on patients (n = 48) undergoing pancreaticoduodenectomy from March 1994 to March 2004 in department of surgery at SMS medical college, Jaipur, India. Demographic variables, details of preoperative stenting, operative procedure and post operative complications were noted. RESULTS: Preoperative biliary drainage was performed in 21 patients (43.5%). The incidence of septic complications was significantly higher in patients with biliary stent placement (P < 0.05, 0 vs 4). This group of patients also had a significantly higher minor biliary leak rate. Mortality and hospital stay in each group was comparable. CONCLUSION: Within this study population the use of PBD by endoscopic stenting was associated with a high incidence of infective complications. These findings do not support the routine use of biliary stenting in patients prior to pancreatico-duodenectomy. | Chandra Shekhar Bhati Chandrashekhar Kubal Pankaj Kumar Sihag Ankur Atal Gupta Raj Kamal Jenav Nicholas G Inston Jagdish M Mehta | 2007 | World Journal of Gastroenterology2007，13，8： | 12 |
| 14 | Significance of blood pressure variability in patients with sepsis显示文摘BACKGROUND: This study was undertaken to observe the characteristics of blood pressure variability(BPV) and sepsis and to investigate changes in blood pressure and its value on the severity of illness in patients with sepsis.METHODS: Blood parameters, APACHE II score, and 24-hour ambulatory BP were analyzed in 89 patients with sepsis.RESULTS: In patients with APACHE II score>19, the values of systolic blood pressure(SBPV), diasystolic blood pressure(DBPV), non-dipper percentage, cortisol(COR), lactate(LAC), platelet count(PLT) and glucose(GLU) were significantly higher than in those with APACHE II score ≤19(P<0.05), whereas the values of procalcitonin(PCT), white blood cell(WBC), creatinine(Cr), PaO2, C-reactive protein(CRP), adrenocorticotropic hormone(ACTH) and tumor necrosis factor α(TNF-α) were not statistically significant(P>0.05). Correlation analysis showed that APACHE II scores correlated significantly with SBPV and DBPV(P<0.01, r=0.732 and P<0.01, r=0.762). SBPV and DBPV were correlated with COR(P=0.018 and r=0.318; P=0.008 and r=0.353 respectively). However, SBPV and DBPV were not correlated with TNF-α, IL-10, and PCT(P>0.05). Logistic regression analysis of SBPV, DBPV, APACHE II score, and LAC was used to predict prognosis in terms of survival and non-survival rates. Receiver operating characteristics curve(ROC) showed that DBPV was a better predictor of survival rate with an AUC value of 0.890. However, AUC of SBPV, APACHE II score, and LAC was 0.746, 0.831 and 0.915, respectively.CONCLUSIONS: The values of SBPV, DBPV and non-dipper percentage are higher in patients with sepsis. DBPV and SBPV can be used to predict the survival rate of patients with sepsis. | Nishant Raj Paney Yu-yao Bian Song-tao Shou | 2014 | World Journal of Emergency Medicine2014，5，1： | 11 |
| 15 | Proposal and validation of a modified staging system to improve the prognosis predictive performance of the 8th AJCC/ UICC pTNM staging system for gastric adenocarcinoma: a multicenter study with external validation显示文摘Background:The 8th edition of the American Joint Committee on Cancer/Union for International Cancer Control(AJCC/UICC)pathological tumor-node-metastasis(pTNM)staging system may have increased accuracy in predicting prognosis of gastric cancer due to its important modifications from previous editions.However,the homogeneity in prognosis within each subgroup classified according to the 8th edition may still exist.This study aimed to compare and analyze the prognosis prediction abilities of the 8th and 7th editions of AJCC/UICC pTNM staging system for gastric cancer and propose a modified pTNM staging system with external validation.Methods:In total,clinical data of 7911 patients from three high-capacity institutions in China and 10,208 cases from the Surveillance,Epidemiology,and End Results(SEER)Program Registry were analyzed.The homogeneity,discrimina-tory ability,and monotonicity of the gradient assessments of the 8th and 7th editions of AJCC/UICC pTNM staging system were compared using log-rank χ^(2),linear-trend χ^(2),likelihood-ratioχ2 statistics and Akaike information criterion(AIC)calculations,on which a modified pTNM classification with external validation using the SEER database was proposed.Results:Considerable stage migration,mainly for stage III,between the 8th and 7th editions was observed in both cohorts.The survival rates of subgroups of patients within stage IIIA,IIIB,or IIIC classified according to both editions were significantly different,demonstrating poor homogeneity for patient stratification.A modified pTNM staging system using data from the Chinese cohort was then formulated and demonstrated an improved homogeneity in these abovementioned subgroups.This staging system was further validated using data from the SEER cohort,and similar promising results were obtained.Compared with the 8th and 7th editions,the modified pTNM staging system displayed the highest log-rank χ^(2),linear-trend χ^(2),likelihood-ratio χ^(2),and lowest AIC values,indicating its superior discriminatory ability,monotonicity,homogeneity and prognosis prediction ability in both populations.Conclusions:The 8th edition of AJCC/UICC pTNM staging system is superior to the 7th edition,but still results in homogeneity in prognosis prediction.Our modified pTNM staging system demonstrated the optimal stratification and prognosis prediction ability in two large cohorts of different gastric cancer populations. | Cheng Fang Wei Wang Jing-Yu Deng Zhe Sun Sharvesh Raj Seeruttun Zhen-Ning Wang Hui-Mian Xu Han Liang Zhi-Wei Zhou | 2018 | Cancer Communications2018，38，1： | 11 |
| 16 | A Rapid and Sensitive One Step-SYBR Green Based Semi Quantitative Real Time RT-PCR for the Detection of peste des petits ruminants Virus in the Clinical Samples显示文摘敏感、快速的单个步实时(rt ) RT-PCR 用一步舞被标准化出众的格林·西布尔工具包吗?为 peste des petitis ruminants 病毒(PPRV ) 的察觉和 semi-quantitation 使用病毒 RNA 和矩阵(M) 蛋白质基因特定的教材并且与确定的常规 RT-PCR 和 TaqMan RT-PCR 相比。试金与 78.28 ~ 78.50 的 Tm 放大 PPRV M 基因的 124 bp 碎片。试金在到有 0.5 fg 的察觉限制(敏感) 的 0.5 fg 总数病毒 RNA 的 50 ng 的一个范围以内是线性的。基于现场稀释的 PPR 疫苗的病毒的连续冲淡,察觉限制是 0.0001 房间文化传染剂量 50% 单位(TCID50 ) 。另外,与疫苗的病毒的已知的 titre 刺的拖把材料同等地好在试金检测了。标准化 rt RT-PCR 容易在这块地和试验性的临床的样品里直接为 PPRV nucleic 酸的察觉被采用。试金从试验性的样品在拖把材料象 3 天柱子感染(dpi ) 和多达 20 dpi 一样早检测了 PPRV nucleic 酸。试金比在从 PPR 的 PPRV nucleic 酸的察觉的 TaqMan 和常规 RT-PCR 怀疑临床的样品绵羊和山羊的快速、更敏感。因此,确定的、简化 SYBR 绿 rt RT-PCR 是一种选择测试各种各样的诊断试金到已经存在并且能为有在减少污染的风险的优点的快速的临床的诊断有用。 | Vinayagamurthy Balamurugan Arnab Sen Gnanavel Venkatesan Vinita Yadav Vandna Bhanot Veerakyathappa Bhanuprakash Raj Kumar Singh | 2012 | Virologica Sinica2012，27，1： | 10 |
| 17 | 一种新型的T形一维镉配位聚合物[Cd(C_5H_4NCOO)·(C_5H_5NCOO)·(NO_3)·(H_2O)]_n(英文)显示文摘Cd(NO3)2· 6H2O和 4-(4-羧基吡啶 )氨基苯甲醛通过温和条件下的水热反应制备了一种新型的中性 T形一维链状配位聚合物,聚合 [(异烟酸根)( 4-羧酸根基吡啶铵)水合硝酸镉 ]。该配合物显示了蓝色荧光性质。 | 曾锡瑞 熊仁根 游效曾 S.Shanmuga Sundar Raj Hoong-Kun Func | 2000 | 无机化学学报2000，16，4： | 10 |
| 18 | Role of bisphosphonates in the management of acute Charcot foot显示文摘Diabetes mellitus is the most common cause of Charcot neuropathy affecting foot and ankle. Acute Charcot foot(CF) presents with a red and swollen foot in co-ntrast to the painless deformed one of chronic CF. En-hanced osteoclastogenesis plays a central role in the pathogenesis of acute CF. Many studies have shown elevated levels of bone turnover markers in patients with acute CF confirming it. These findings have led cl-inicians to use anti-resorptive agents [bisphosphonates(BP), calcitonin, and denosumab] along with immobi-lization and offloading in acute CF patients. The ma-ximum evidence among all anti-resorptive agents is available for BPs, although its quality is low. Pamidronate has been shown to reduce the markers of activity of CF like raised skin temperature, pain, edema, and bone turnover markers in the majority of studies. Intravenous BPs are known to cause acute phase reactions leading to flu-like illness following their first infusion, which can be ameliorated by oral acetaminophen. Alendronate is the only oral BP used in these patients. It needs to be taken on an empty stomach with a full glass of water to avoid esophagitis. The side-effects and contraindications to BPs should be kept in mind while treating acute CF patients with them. | Harsh Durgia Jayaprakash Sahoo Sadishkumar Kam-alanathan Rajan Palui Kalyani Sridharan Henith Raj | 2018 | World Journal of Diabetes2018，9，7： | 9 |
| 19 | SGLT-2 inhibitors in non-alcoholic fatty liver disease patients with type 2 diabetes mellitus: A systematic review显示文摘BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is a common comorbidity with type 2 diabetes.The existing therapeutic options for NAFLD are not adequate.Hypocaloric diet and exercise is the cornerstone of therapy in NAFLD.Pioglitazone is the only drug recommended in diabetes patients with biopsy proven non-alcoholic steatohepatitis.The frequent coexistence of NAFLD and type 2 diabetes with their combined adverse health consequences and inadequate therapeutic options makes it necessary to search for newer alternatives.AIM To assess the effect of sodium glucose cotransporter-2(SGLT-2)inhibitors on liver enzymes in type 2 diabetes patients with NAFLD.METHODS We searched PubMed/MEDLINE,Cochrane library,Google scholar,and Clinicaltrials.gov for the relevant articles to be included in this systematic review.Human studies done in type 2 diabetes patients with NAFLD treated with SGLT-2 inhibitors for at least 12 wk were included.Data from eight studies(four randomised controlled trials and four observational studies)were extracted and a narrative synthesis was done.A total of 214 patients were treated with SGLT-2 inhibitors in these studies(94 in randomised controlled trials and 120 in observational studies).RESULTS The primary outcome measure was change in serum alanine aminotransferase level.Out of eight studies,seven studies showed a significant decrease in serum alanine aminotransferase level.Most of the studies revealed reduction in serum level of other liver enzymes like aspartate aminotransferase and gamma glutamyl transferase.Five studies that reported a change in hepatic fat exhibited a significant reduction in hepatic fat content in those treated with SGLT-2 inhibitors.Likewise,among the three studies that evaluated a change in indices of hepatic fibrosis,two studies revealed a significant improvement in liver fibrosis.Moreover,there was an improvement in obesity,insulin resistance,glycaemia,and lipid parameters in those subjects taking SGLT-2 inhibitors.The studies disclosed that about 17%(30/176)of the subjects taking SGLT-2 inhibitors developed adverse events and more than 40%(10/23)of them had genitourinary tract infections.CONCLUSION Based on low to moderate quality of evidence,SGLT-2 inhibitors improve the serum level of liver enzymes,decrease liver fat,and fibrosis with additional beneficial effects on various metabolic parameters in type 2 diabetes patients with NAFLD. | Henith Raj Harsh Durgia Rajan Palui Sadishkumar Kamalanathan Sandhiya Selvarajan Sitanshu Sekhar Kar Jayaprakash Sahoo | 2019 | World Journal of Diabetes2019，10，2： | 9 |
| 20 | 未来中国医疗模式发展趋势探讨显示文摘传统医学模式在推动人类健康发展的道路上曾经取得了巨大进步,但如今传统医学模式专业化加深,导致人体'碎片化'的弊端日益显著,而国际上新兴的整合医学也存在专业知识粗糙、相关研究局限于学术层面等明显的缺点。就这两种医疗模式的优劣进行讨论并分析目前医疗模式的困境,提出未来中国医疗模式发展趋势是个体医疗和团队化医疗小组结合,认为其是解决现代医学自身缺陷、缓解医疗矛盾的有效手段。 | 边毓尧 Nishant Raj Pandey 刘创建 修明文 张祎 | 2016 | 医学与社会2016，29，1： | 9 |
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