|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Crohn's disease environmental factors in the developing world: A case-control study in a statewide catchment area in Brazil显示文摘AIM To identify environmental risk factors associated with the development of Crohn's disease(CD) in order to reassess the hygiene hypothesis.METHODS A hospital-based, case-control study was carried out with CD patients(n = 145) and controls(n = 163)representing a socioeconomically diverse statewide catchment area in Brazil. Controls were recruited from caregivers of patients seen in different outpatient clinics at the same hospital. A multi-item survey with 94 questions regarding family history of CD, perinatal and childhood circumstances, living conditions, tobacco use and familial socioeconomic status was carried out by interviewers. RESULTS On the univariate analysis, predictive variables for CD included being male, under age of 40, a high education level, urban dweller, smaller family size, exposure to enteric pathogens and user of treated water(P < 0.005). On the multivariate analysis, variables significantly associated with CD were male gender(OR = 2.09), under age 40(OR = 3.10), white(OR = 2.32), from a small family in childhood(OR = 2.34) and adulthood(OR = 3.02), absence of viral infections in childhood(OR = 2.23), exposure to enteric pathogens(OR = 2.41), having had an appendectomy(OR = 2.47) and prior or current smoker(OR = 2.83/1.12). CONCLUSION Most variables supporting the 'hygiene hypothesis' are associated with the development of CD but are not independent predictors of the diagnosis. | Valéria Cristina Loureiro Salgado Ronir Raggio Luiz Neio Boechat Bianca C Schorr Isabella S Leao Tiago Nunes Cyrla Zaltman | 2017 | World Journal of Gastroenterology2017，23，30： | 2 |
| 2 | Marfan syndrome: orthopedic and genetic review 显示文摘 | GIAMPIETRO PF RAGGIO C DAVIS JG | 2002 | Curr Opin Pediatr2002，14，1： | 1 |
| 3 | Marfan syndrome:orthopedic and genetic review 显示文摘 | Giampietro PF Raggio C Davis JG | 2002 | Curt Opin Pediatr2002，14，1： | 1 |
| 4 | Marfan syndrome:orthopedic and genetic review显示文摘 | Giampietro PF Raggio C Davis JG | 2002 | Curr Opin Pediatr2002，14，1： | 1 |
| 5 | Marfan syndrome:or- thopedic and genetic review 显示文摘 | Giampietro PF Raggio C Davis JG | 2002 | Curr Opin Pediatr2002，14，1： | 1 |
| 6 | Brand creation vs acquisition in portfolio expansion strategy 显示文摘 | DAMOISEAU Y BLACK W C RAGGIO R D | 2011 | Journal of Product & Brand Management2011，20，4： | 1 |
| 7 | Marfan syndrome:Orthopedic and genetic review显示文摘 | Giamp ietro PF Raggio C Davis JG | 2002 | Curr OP in pediatr2002，，1： | 1 |
| 8 | Marfan syndrome: orthopedic and genetic review显示文摘 | Giampietro PF Raggio C Davis JG | 2002 | Curr Opin Pedian''2002，14，1： | 1 |
| 9 | Effect of casein and propionate supply in mammary protein metabolism in lactating dairy cows显示文摘 | Raggio C Lemosquet S Lobley G E | 2006 | Journal of Dairy Science2006，89，： | 1 |
| 10 | Marfan syndrome:orthopedic and genetic review显示文摘 | Giampietro PF Raggio C Davis JG | 2002 | Curr Opin Pediatr2002，14，1： | 1 |
| 11 | Risk factors associated with inflammatory bowel disease: A multicenter case-control study in Brazil显示文摘BACKGROUND The etiology of inflammatory bowel disease(IBD)is unknown,but it is believed to be multifactorial.The hygiene hypothesis proposes that better hygiene conditions would lead to less infectious disease during childhood and favor the development of immune-mediated diseases.AIM To test the hygiene hypothesis in IBD by assessing the environmental risk factors associated with IBD development in different regions of Brazil with diverse socioeconomic development indices.METHODS A multicenter case-control study was carried out with 548 Crohn’s disease(CD)and 492 ulcerative colitis(UC)outpatients and 416 healthy controls,from six IBD centers within different Brazilian states at diverse socioeconomic development stages.A semi-structured questionnaire with 87 socioeconomic and environmental questions was applied.Logistic regression model was created to assess the odds ratio(OR)with P value and 95%confidence intervals(CI).RESULTS Predictive variables for both diseases(CD and UC)were women[odd ratios(OR)=1.31;OR=1.69],low monthly family income(OR=1.78;OR=1.57),lower number of cohabitants(OR=1.70;OR=1.60),absence of vaccination(OR=3.11;OR=2.51),previous history of bowel infections(OR=1.78;OR=1.49),and family history of IBD(OR=5.26;OR=3.33).Associated risk factors for CD were age(18-39 years)(OR=1.73),higher educational level(OR=2.22),absence of infectious childhood diseases(OR=1.99).The UC predictive variables were living in an urban area(OR=1.62),inadequate living conditions(OR=1.48)and former smokers(OR=3.36).Appendectomy was a risk factor for CD(OR=1.58)with inverse association with UC(OR=4.79).Consumption of treated and untreated water was associated with risk of CD(OR=1.38)and UC(OR=1.53),respectively.CONCLUSION This is the first examining environmental exposures as risk factors for inflammatory bowel disease in Brazil.Most of the variables associated with disease risk support the role of the hygiene hypothesis in IBD development. | Valéria Cristina Loureiro Salgado Ronir Raggio Luiz Neio Lucio Fernandes Boéchat Isabella Sued Leao Bianca do Carmo Schorr JoséMiguel Luz Parente Daniela Calado Lima Eduardo Santos Silveira Júnior Genoile Oliveira Santana Silva Neogélia Pereira Almeida Andrea Vieira Maria Luiza Queiroz de Bueno Júlio Maria Chebli érika Ruback Bertges Luísa Martins da Costa Brugnara Columbano Junqueira Neto Stefania Burjack Gabriel Campbell Luana Letiza Discacciati Joao Paulo Silva Cézar Tiago Nunes Gilaad G Kaplan Cyrla Zaltman | 2020 | World Journal of Gastroenterology2020，26，25： | 1 |
| 12 | Marfan syndrome orthopedic and genetic review显示文摘 | Giampietro PF Raggio C Davis JG | 2002 | Curr Opin Pediatr2002，14，1： | 1 |
| 13 | Marfan syndrome:orthopedic and genetic review显示文摘 | Giampietro PF Raggio C Davis JG | 2002 | Curr Opin Pediatr2002，14，1： | 1 |
| 14 | Congenital and idiopathic scoliosis:clinical and genetic aspects显示文摘 | Giampietro P F Blank R D Raggio C L | | 0，，02： | 1 |
| 15 | DLL3 as a candidate gene for vertebral malformations显示文摘 | Giampietro PF Raggio CL Reynolds C | 2006 | Am J Med Genet2006，140，22： | 1 |
| 16 | Marfan syndrome: orthopedic and genetic review显示文摘 | Raggio C David JG | 2002 | Curr Opin Pediatr2002，14，： | 1 |
| 17 | Ecological study of gastric cancer in Brazil:Geographic and time trend analysis显示文摘AIM:To investigate the geographic distributions and time trends of gastric cancer(GC)incidence and mortality in Brazil.METHODS:An ecological study of the DATASUS registry was conducted by identifying hospitalizations for GC between January 2005 and December 2010.The data included information on the gender,age,and town of residence at the time of hospital admission and death.RESULTS:The GC rates,adjusted according to available hospital beds,decreased from 13.8 per 100000in 2005 to 12.7 per 100000 in 2010.The GC rates decreased more among the younger age groups,in which the male-to-female difference also decreased in comparison to the older age groups.Although the lethality rates tended to increase with age,young patients were proportionally more affected.The spatial GC distribution showed that the rates were higher in the south and southeast.However,while the rates decreased in the central-west and south,they increased in the northern regions.A geographic analysis showed higher rates of GC in more urbanized areas,with a coast-toinland gradient.Geographically,GC lethality overlapped greatly with the hospital admission rates.CONCLUSION:The results of this study support the hypothesis of a critical role for environmental factors in GC pathogenesis.The declining rates in young patients,particularly males,suggest a relatively recent decrease in the exposure to risk factors associated with GC.The spatial distribution of GC indicates an ongoing dynamic change within the Brazilian environment. | César Augusto Amorim Jéssica Pronestino Moreira Luisa Rial Antonio José Carneiro Homero Soares Foga?a Celeste Elia Ronir Raggio Luiz Heitor Siffert Pereira de Souza | 2014 | World Journal of Gastroenterology2014，20，17： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员