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| 1 | Vitamin E ameliorates aflatoxin-induced biochemical changes in the testis of mice显示文摘Aim: To assess the effect of aflatoxin on biochemical changes in the testis of mice and the possibility of amelioration by vitamin E treatment. Methods: Adult male albino mice were orally administered with 25 or 50 tg of aflatoxin/animal/day (750 or 1500 μg/kg body weight) for 45 days. The testis was isolated and processed for biochemical analysis. Results: There was a significant, dose-dependent reduction in DNA, RNA, protein, sialic acid contents and the activities of succinic dehydrogenase, adenosine triphosphatase and alkaline phosphatase in the testis of aflatoxintreated mice as compared to the vehicle control. However, the acid phosphatase activity was significantly increased in the aflatoxin-treated mice. Vitamin E (2 mg/animal/day) treatment significantly ameliorated the aflatoxin-induced changes, except the acid and alkaline phosphatase activities in the high dose group. Conclusion: Vitamin E treatment ameliorates the aflatoxin-induced changes in the testis of mice. | R.J.Verma Anita Nair | 2001 | Asian Journal of Andrology2001，3，4： | 2 |
| 2 | Ameliorative effect of vitamin E on aflatoxin-induced lipid peroxidation in the testis of mice显示文摘Aim: To evaluate the ameliorative effect of vitamin E on aflatoxin-induced lipid peroxidation in the testis. Methods: Adult male albino mice were orally administered 25 or 50 μg of aflatoxin in 0.2 mL olive oil per d for 45 d.The testis was isolated, blotted free of blood and processed for biochemical analysis. Results: There was a dose-dependent significantlyhigher lipid peroxidation in the testis of aflatoxin treated mice than in the controls. The levels of non-enzymatic antioxidants such as glutathione, total and reduced ascorbic acid, as well as the activities of enzymatic antioxidants, such as superoxide dismutase, glutathione peroxidase and catalase were significantly lower in the testis of aflatoxin treated mice. Vitamin E (2 mg/d per animal; orally) pretreatment significantly ameliorates the aflatoxin-induced lipid peroxidation which could be due to higher enzymatic and non-enzymatic antioxidants in the testis of mice as compared with those given aflatoxin alone. Conclusion: Vitamin E pretreatment significantly ameliorates aflatoxininduced lipid peroxidation in the testis of mice. | R.J.Verma Anita Nair | 2001 | Asian Journal of Andrology2001，3，3： | 2 |
| 3 | Effect of papaya seed extract on microenvironment of cauda epididymis显示文摘Aim: To evaluate the effect of aqueous Carica papaya seed extract on microenvironment of cauda epididymis.Methods: Adult male albino rats were intrauscularly administered with 0 (control) or 0.5 mg papaya seed ex tract/kg body weight for 7 days. Cauda epididymal tubular content was collected by micropuncture technique; epididy real luminal fluid and sperm pellets were separately analyzed. Results: The results revealed that the extract treat ment caused significant reduction, as compared with control, in total protein and sialic acid contents in both epididymal fluid and sperm pellet. As compared with control, significantly lowered acid phosphatase activity was recorded in spermpellet but was higher in epididymal fluid after the treatment. The extract treatment also caused significant reduction in level of inorganic phosphorus in the ePididymal fluid. Conclusion: It is concluded that the aqueous papaya seed ex tract alters cauda epididymal microenvironment. | R.J.Verma N.J.Chinoy | 2001 | Asian Journal of Andrology2001，3，2： | 1 |
| 4 | Arsenic toxicity in mice and its possible amelioration显示文摘Oral administration of arsenic trioxide(3 and 6 mg/kg body weight/d) for 30 d caused, as compared with vehicle control, dose dependent significant reductions in body weight, absolute weight, protein, glycogen, as well as, total, dehydro and reduced ascorbic acid contents both in the liver and kidney of arsenic treated mice. Succinic dehydrogenase(SDH) and phosphorylase only in the liver activities were significantly reduced in a dose dependent manner. Acid phosphatase activity was significantly decreased in the liver of low dose arsenic treated animals; however, significant rise in its activity was observed in high dose group. As compared with vehicle control, treatment also caused significant dose dependent reductions in SDH, alkaline phosphatase and acid phosphatase activities in the kidney of mice. Vitamin E cotreatment as well as, 30 d withdrawal of arsenic trioxide treatment with or without vitamin E caused significant amelioration in arsenic induced toxicity in mice. Administration of vitamin E during withdrawal of treatment also caused significant amelioration as compared from only withdrawal of the treatment. It is concluded that vitamin E ameliorates arsenic induced toxicities in the liver and kidney of mice. | R.J.Verma Archana Vasu Abdul Alim Saiyed | 2004 | Journal of Environmental Sciences2004，16，3： | 0 |
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