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| 1 | Damage control resuscitation: the need for specific blood products to treat the coagulopathy of trauma显示文摘 | John R.Hess John B.Holcomb David B.Hoyt | 2006 | Transfusion2006，，5： | 1 |
| 2 | “Life is short,and art is long”:RNA degradation in cyanobacteria and model bacteria显示文摘RNA turnover plays critical roles in the regulation of gene expression and allows cells to respond rapidly to environmental changes.In bacteria,the mechanisms of RNA turnover have been extensively studied in the models Escherichia coli and Bacillus subtilis,but not much is known in other bacteria.Cyanobacteria are a diverse group of photosynthetic organisms that have great potential for the sustainable production of valuable products using CO_(2)and solar energy.A better understanding of the regulation of RNA decay is important for both basic and applied studies of cyanobacteria.Genomic analysis shows that cyanobacteria have more than 10 ribonucleases and related proteins in common with E.coli and B.subtilis,and only a limited number of them have been experimentally investigated.In this review,we summarize the current knowledge about these RNAturnover-related proteins in cyanobacteria.Although many of them are biochemically similar to their counterparts in E.coli and B.subtilis,they appear to have distinct cellular functions,suggesting a different mechanism of RNA turnover regulation in cyanobacteria.The identification of new players involved in the regulation of RNA turnover and the elucidation of their biological functions are among the future challenges in this field. | Ju-Yuan Zhang Wolfgang R.Hess Cheng-Cai Zhang | 2022 | mLife2022，1，1： | 1 |
| 3 | Communicating clearly about conservation corridors显示文摘 | George R.Hess Richard A.Fischer | | 0，，55： | 1 |
| 4 | Glucose metabolism gene polymorphisms and clinical outcome in pancreatic cancer显示文摘 | XiaoqunDong HongweiTang Kenneth R.Hess James L.Abbruzzese DonghuiLi | 2011 | Cancer2011，，3： | 1 |
| 5 | Phase 2 trial of oxaliplatin plus capecitabine (XELOX) as second‐line therapy for patients with advanced pancreatic cancer显示文摘 | Henry Q.Xiong Gauri R.Varadhachary Joan C.Blais Kenneth R.Hess James L.Abbruzzese Robert A.Wolff | 2008 | Cancer2008，，8： | 1 |
| 6 | Metastatic patterns in adenocarcinoma显示文摘 | Kenneth R.Hess Gauri R.Varadhachary Sarah H.Taylor WeiWei Martin N.Raber RenatoLenzi James L.Abbruzzese | 2006 | Cancer2006，，7： | 1 |
| 7 | Regulation of RNase E during the UV stress response in the cyanobacterium Synechocystis sp.PCC 6803显示文摘Endoribonucleases govern the maturation and degradation of RNA and are indispensable in the posttranscriptional regulation of gene expression.A key endoribonuclease in Gram-negative bacteria is RNase E.To ensure an appropriate supply of RNase E,some bacteria,such as Escherichia coli,feedback-regulate RNase E expression via the rne 5′-untranslated region(5′UTR)in cis.However,the mechanisms involved in the control of RNase E in other bacteria largely remain unknown.Cyanobacteria rely on solar light as an energy source for photosynthesis,despite the inherent ultraviolet(UV)irradiation.In this study,we first investigated globally the changes in gene expression in the cyanobacterium Synechocystis sp.PCC ^(6)803 after a brief exposure to UV.Among the 407 responding genes 2 h after UV exposure was a prominent upregulation of rne mRNA level.Moreover,the enzymatic activity of RNase E rapidly increased as well,although the protein stability decreased.This unique response was underpinned by the increased accumulation of full-length rne mRNA caused by the stabilization of its 5′UTR and suppression of premature transcriptional termination,but not by an increased transcription rate.Mapping of RNA 3′ends and in vitro cleavage assays revealed that RNase E cleaves within a stretch of six consecutive uridine residues within the rne 5′UTR,indicating autoregulation.These observations suggest that RNase E in cyanobacteria contributes to reshaping the transcriptome during the UV stress response and that its required activity level is secured at the RNA level despite the enhanced turnover of the protein. | Satoru Watanabe Damir Stazic Jens Georg Shota Ohtake Yutaka Sakamaki Megumi Numakura Munehiko Asayama Taku Chibazakura Annegret Wilde Claudia Steglich Wolfgang R.Hess | 2023 | mLife2023，2，1： | 0 |
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