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| 1 | Adiponectin signalling in bone homeostasis,with age and in disease显示文摘Adiponectin is the most abundant circulating adipokine and is primarily involved in glucose metabolism and insulin resistance.Within the bone,osteoblasts and osteoclasts express the adiponectin receptors,however,there are conflicting reports on the effects of adiponectin on bone formation and turnover.Many studies have shown a pro-osteogenic role for adiponectin in in vivo murine models and in vitro:with increased osteoblast differentiation and activity,alongside lower levels of osteoclastogenesis.However,human studies often demonstrate an inverse relationship between adiponectin concentration and bone activity.Moreover,the presence of multiple isoforms of adiponectin and multiple receptor subtypes has the potential to lead to more complex signalling and functional consequences.As such,we still do not fully understand the importance of the adiponectin signalling pathway in regulating bone homeostasis and repair in health,with age and in disease.In this review,we explore our current understanding of adiponectin bioactivity in the bone;the significance of its different isoforms;and how adiponectin biology is altered in disease.Ultimately,furthering our understanding of adiponectin regulation of bone biology is key to developing pharmacological and non-pharmacological(lifestyle)interventions that target adiponectin signalling to boost bone growth and repair in healthy ageing,following injury or in disease. | Jonathan W.Lewis James R.Edwards Amy J.Naylor Helen M.McGettrick | 2021 | Bone Research2021，9，1： | 8 |
| 2 | BREACH AND FULFILLMENT OF THE PSYCHOLOGICAL CONTRACT: A COMPARISON OF TRADITIONAL AND EXPANDED VIEWS显示文摘 | LISA SCHURERLAMBERT JEFFREY R.EDWARDS DANIEL M.CABLE | 2006 | Personnel Psychology2006，，4： | 2 |
| 3 | Electrical events underlying organized myogenic contractions of the guinea pig stomach显示文摘 | G. David S.Hirst Frank R.Edwards | 2006 | The Journal of Physiology2006，，3： | 1 |
| 4 | Cash-flow taxation of financial services显示文摘 | Peter R.Merrill Chris R.Edwards | | 0，，03： | 1 |
| 5 | Leadership,burnout,and job satisfaction in outpatient drug-free treatment programs显示文摘 | Kirk M.Broome Danica K.Knight Jennifer R.Edwards Patrick M.Flynn | | 0，，02： | 1 |
| 6 | Deep mantle plumes and an increasing Earth radius显示文摘Recent space geodetic and gravimetric studies have given indications that the Earth’s radius is increasing at 0.1-0.4 mm yr-1 at present. Seismic studies have also shown that earthquakes alone could be causing the radius to increase at 0.011-0.06 mm yr-1. Deep mantle plumes provide a geophysical context within which such radial expansion, if confirmed, could possibly be explained. Both theory and observation suggest that these rising plumes more readily penetrate the 670 km barrier than do subducting slabs moving in the opposite direction towards the core-mantle boundary. If so, there would be a net flow of mass from the deep lower mantle into the upper mantle. Due to the lower pressures in the upper mantle,the excess mass of plume materials reaching there would transform to minerals with lower densities than they had at the mantle base. An increase in the mantle volume and the Earth’s radius would therefore be implied. Using previously published data for the African superplume. it is estimated that this mechanism could cause the Earth’s radius to increase at rates of 0.02-0.3 mm yr-1, similar to the rates possibly indicated in the present studies. This mechanism could also explain the very large range in current estimates of mantle plume heat and volume fluxes. A possible energy source for this plumedriven mode of expansion is discussed. | Matthew R.Edwards | 2019 | Geodesy and Geodynamics2019，10，3： | 1 |
| 7 | 预防医院耐药菌感染--2014年美国显示文摘耐药菌是一种世界性的公共卫生威胁。2013年疾病预防控制中心(CDC)的一项报告概述了美国前18位危急和严重级别的耐药相关的威胁。 | Lindsey M.Weiner,MPH Scott K.Fridkin,MD Zuleika Aponte-Torres,MPH Lacey Avery,MA Nicole Coffin,MA Margaret A.Dudeck,MPH Jonathan R.Edwards,MStat John A.Jernigan,MD Rebecca Konnor,MPH Minn M.Soe,MBBS,MPH Kelly Peterson L.Clifford McDonald,MD 刘洪霞(综述) 金克峙(审校) | 2017 | 上海预防医学2017，29，2： | 1 |
| 8 | Preliminary Studies of Speleothem in Central Asia显示文摘Objective The Westerlies is important in linking the Northern high latitude,North Atlantic and East Asian monsoon.The location and intensity of the Westerly jet can not only control the climate of central Asia(including northwest arid China),but also significantly influence the climate of the East Asian monsoon region.However,it | TAN Liangcheng SONG Yougui CAI Yanjun AN Zhisheng Rustam OROZBAEV Yunus MAMADJANOV Lawrence R.EDWARDS CHENG Hai LI Dong LI Yue | 2016 | Acta Geologica Sinica(English Edition)2016，90，6： | 0 |
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