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| 1 | Pharmacokinetic evaluation,molecular docking and in vitro biological evaluation of 1,3,4-oxadiazole derivatives as potent antioxidants and STAT3 inhibitors显示文摘1, 3, 4-Oxadiazole derivatives(4 a–5 f) were previously synthesized to investigate their anticancer properties.However, studies relating to their antioxidant potential and signal transducer and activator of transcription(STAT) inhibition have not been performed. We investigated previously synthesized 1, 3, 4-oxadiazole derivatives(4 a–5 f) for various radical scavenging properties using several in vitro antioxidant assays and also for direct inhibition of STAT3 through molecular docking. The data obtained from various antioxidant assays such as 2, 2,-diphenyl-1-picrylhydrazyl radical(DPPH), nitric oxide, hydrogen peroxide, and superoxide anion radical revealed that among all the derivatives, compound 5 e displayed high antioxidant activities than the standard antioxidant L-ascorbic acid. Additionally, the total reduction assay and antioxidant capacity assay further confirmed the antioxidant potential of compound 5 e. Furthermore, the molecular docking studies performed for all derivatives along with the standard inhibitor STX-0119 showed that binding energy released in direct binding with the SH2 domain of STAT3 was the highest for compound 5 e(-9.91 kcal/mol).Through virtual screening, compound 5 e was found to exhibit optimum competency in inhibiting STAT3 activity. Compound 5 e decreased the activation of STAT3 as observed with Western blot. In brief, compound5 e was identified as a potent antioxidant agent and STAT3 inhibitor and effective agent for cancer treatment. | Rashmin khanam Iram I.Hejazi Syed Shahabuddin Abdul R.Bhat Fareeda Athar | 2019 | Journal of Pharmaceutical Analysis2019，9，2： | 1 |
| 2 | A Comprehensive Analysis of Built Environment Characteristicson Household Residential Choice and Auto Ownership Levels显示文摘 | Chandra R.Bhat JessicaY.Guo | | 0，，： | 1 |
| 3 | Cell signaling associated with internalization of 67 kDa laminin receptor (67LR) by soluble laminin and its implication for protection against neurodegenerative diseases显示文摘Various isoforms of laminins are present in the basement membranes complexed with other structural proteins.In the central nervous system(CNS),they are primarily localized to the basement membranes of blood vessels and reactive astrocytes.Limited amounts of various laminin isoforms are also associated with neuronal cell bodies and axons,which are referred to as“neuronal”laminins(Yamamoto et al.,1988).They exist in a soluble form,free from other basement membrane proteins.Neurons either produce these soluble laminins or acquire them from astroglial cells.Laminin stimulates neuritogenesis and confers neuroprotection in vitro,but their exact role of these neuronal soluble laminins in the CNS is yet unknown. | Rayudu Gopalakrishna Narayan R.Bhat Sarah Zhou William J.Mack | 2019 | Neural Regeneration Research2019，14，9： | 1 |
| 4 | The High Time Resolution Universe Pulsar Survey – I. System configuration and initial discoveries显示文摘 | M. J.Keith A.Jameson W.van Straten M.Bailes S.Johnston M.Kramer A.Possenti S. D.Bates N. D. R.Bhat M.Burgay S.Burke‐Spolaor N.D’Amico L.Levin Peter L.McMahon S.Milia B. W.Stappers | 2010 | Monthly Notices of the Royal Astronomical Society2010，，2： | 1 |
| 5 | Changes in body composition in relation to estimated glomerular filtration rate and physical activity in predialysis chronic kidney disease显示文摘Background: Early body composition changes, associated with physical inactivity and disease advancement are devastating for patient-related outcomes in predialysis chronic kidney disease (CKD), thus warranting a detailed analysis of body composition beyond conventional measures.Methods: The study included 40 subjects diagnosed with CKD;recruited between January to May 2021. Body composition was measured using the multifrequency analyzer, InBody 770. International Physical Activity Questionnaire-Short Form was used to assess physical activity. Suitable statistical analyses were performed using SPSS 21.0.Results: The mean age of the subjects was 58.68 ± 12.24 years. Sarcopenic obesity was prevalent in 62.5% of the subjects. Body mass index under identified obesity by 15% compared to percent body fat, especially in subjects with low muscle mass. The decline in a unit of estimated glomerular filtration rate (eGFR) significantly correlated with a decrease in weight (p = 0.02), body fat mass (p = 0.05), visceral fat area (p = 0.05), and phase angle (p = 0.01) with marginal changes in waist–hip ratio and extracellular water/total body water. The effect of physical activity on skeletal muscle mass was homogeneous between low and moderate levels, but significantly different from high activity level.Conclusion: Changes in fat and fluid compartment were associated with eGFR decline, whereas higher physical activity positively affected body composition. | Prathiksha R.Bhat Asna Urooj Srinivas Nalloor | 2022 | Chronic Diseases and Translational Medicine2022，8，4： | 0 |
| 6 | Cyclic adenosine monophosphate-elevating agents inhibit amyloid-beta internalization and neurotoxicity:their action in Alzheimer's disease prevention显示文摘Recently,we have found that various intracellular cyclic adenosine monophosphate(cAMP)-e leva ting agents,both pharmacological(dibutyryl-cAMP,forskolin,and rolipram)and physiological(pituitary adenylate cyclase-activating polypeptide),decrease cell-surface levels of 67-kDa laminin receptor(67LR)and cellular prion protein(PrP~C). | Rayudu Gopalakrishna Andrew Oh Narayan R.Bhat William J.Mack | 2023 | Neural Regeneration Research2023，18，12： | 0 |
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