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2篇 您的检索式:作者名="Narayan R.Bhat"
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1Cell signaling associated with internalization of 67 kDa laminin receptor (67LR) by soluble laminin and its implication for protection against neurodegenerative diseases显示文摘Various isoforms of laminins are present in the basement membranes complexed with other structural proteins.In the central nervous system(CNS),they are primarily localized to the basement membranes of blood vessels and reactive astrocytes.Limited amounts of various laminin isoforms are also associated with neuronal cell bodies and axons,which are referred to as“neuronal”laminins(Yamamoto et al.,1988).They exist in a soluble form,free from other basement membrane proteins.Neurons either produce these soluble laminins or acquire them from astroglial cells.Laminin stimulates neuritogenesis and confers neuroprotection in vitro,but their exact role of these neuronal soluble laminins in the CNS is yet unknown.Rayudu Gopalakrishna Narayan R.Bhat Sarah Zhou William J.Mack 2019Neural Regeneration Research2019,14,9:1
2Cyclic adenosine monophosphate-elevating agents inhibit amyloid-beta internalization and neurotoxicity:their action in Alzheimer's disease prevention显示文摘Recently,we have found that various intracellular cyclic adenosine monophosphate(cAMP)-e leva ting agents,both pharmacological(dibutyryl-cAMP,forskolin,and rolipram)and physiological(pituitary adenylate cyclase-activating polypeptide),decrease cell-surface levels of 67-kDa laminin receptor(67LR)and cellular prion protein(PrP~C).Rayudu Gopalakrishna Andrew Oh Narayan R.Bhat William J.Mack 2023Neural Regeneration Research2023,18,12:0
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