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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Detailed balance limit of efficiency of p-n junction solar cells显示文摘 | William Shockley Hans J Queisser | | 0，，： | 1 |
| 3 | Malformations in newborn: results based on 30,940 infants and fetuses from the Mainz congenital birth defect monitoring system(1990-1998)显示文摘 | Queisser LA Stolz G Wiesel A et M | 2002 | Arch Gynecol Obstet2002，266，3： | 1 |
| 4 | Detailed balance limit of efficiency of p-n junction solarcells显示文摘 | SHOCKLEY W QUEISSER H J | 1961 | Appl Phys1961，32，3： | 1 |
| 5 | Detailed balance limit of efficiency of p-n junction solar cells 显示文摘 | Shockley W Queisser H J | 1961 | Journal of Applied Physics1961，32，3： | 1 |
| 6 | Detailed balance limit of efficiency of p-n junction solar cells显示文摘 | SHOCKLEY W QUEISSER H J | 1966 | Journal of Applied Physics1966，32，3： | 1 |
| 7 | Hyperglycemia impairs proteasome function by methylglyoxal显示文摘 | Queisser MA Yao D Geisler S | 2010 | Diabetes2010，59，3： | 1 |
| 8 | Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones显示文摘 | Saffarzadeh M Juenemann C Queisser MA | 2012 | PLoS One2012，7，32： | 1 |
| 9 | Detailed Balance Limit of Efficiency of p-n Junction Solar Cells显示文摘 | Shockly W Queisser J H | 1961 | Journal of Applied Physics1961，32，3： | 1 |
| 10 | Loss of RAGE in pulmonary fibrosis: molecular relations to functional cha- nges in pulmonary cell types显示文摘 | Queisser MA Kouri FM K~nigshoff M et a/ | 2008 | Am J Respir Cell Mol Biol2008，39，3： | 1 |
| 11 | Detailed Balance Limit of Efficiency of P-N Junction Solar Cells显示文摘 | Shockley W Queisser H J | 1961 | Journal of Applied Physics1961，32，3： | 1 |
| 12 | Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappa B and STAT3 pathways in Hodgkin's lymphoma cells显示文摘 | MACKENZIE GG QUEISSER N WOLFSON ML | 2008 | Int J Cancer2008，123，1： | 1 |
| 13 | Detailed balance limit of efficiency of p-n junction solar cells显示文摘 | SHOCKLEY W QUEISSER H J | 1961 | J Appl Phys1961，32，3： | 1 |
| 14 | Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones 显示文摘 | Saffarzadeh M Juenemann C Queisser MA | 2012 | PLo One2012，7，32： | 1 |
| 15 | Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin 's lymphoma cells 显示文摘 | Mackenzie GG Queisser N Wolfson ML etal | 2008 | Int J Cancer2008，123，1： | 1 |
| 16 | Detailed balance limit of efficiency of p-n junction solar cells显示文摘 | Shockley W Queisser H J | | 0，，： | 1 |
| 17 | Human motoric behavior as a fartor for workplace design of ship control stations显示文摘 | Queisser S | 1991 | The International Symposium on Maritime Health1991，，： | 1 |
| 18 | Interface-State Measurements at Schottky Contacts: A New Admittance Technique 显示文摘 | Wemer J H Ploog K Queisser H J | 1986 | Physical Review Letters1986，57，8： | 1 |
| 19 | Curcumin induces cell arrested and apoptosis in associated with the inhibition of constitively active NF-κ3 and STAT 3 pathways in Hodgkin's lymphoma cells 显示文摘 | Gerardo G Mackenzie Nina Queisser | 2008 | Int J Cancer2008，123，3： | 1 |
| 20 | Curcumin induces cell-arrest and apoptcsis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells显示文摘 | Mackenzie GG Queisser N Wolfson ML | 2008 | IntJ Cancer2008，123，1： | 1 |
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