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| 1 | Peptidergic innervation of human esophageal and cardiac carcinoma显示文摘AIM: To investigate the distribution of neuropeptideimmunoreactive nerve fibers in esophageal and cardiac carcinoma as well as their relationship with tumor cells so as to explore if there is nerve innervation in esophageal and cardiac carcinoma.METHODS: Esophageal and cardiac carcinoma specimens were collected from surgical operation. One part of them were fixed immediately with 4 % paraformaldehyde and then cut with a cryostat into 40-pm-thick sections to perform immunohistochemical analysis. Antibodies of ten kinds of neuropeptide including calcitonin gene-related peptide (CGRP), galanin (GAL), substance P (SP), etc. were used for immunostaining of nerve fibers. The other part of the tumor specimens were cut into little blocks (1 mm3) and cocultured with chick embryo dorsal root ganglia (DRG) to investigate if the tumor blocks could induce the neurons of DRG to extend processes, so as to probe into the possiblereasons for the nerve fibers growing into tumors. RESULTS: Substantial amounts of neuropeptide including GAL-, NPY-, SP-immunoreactive nerve bundles and scattered nerve fibers were distributed in esophageal and cardiac carcinomas. The scattered nerve fibers waved their way among tumor cells and contacted with tumor cells closely. Some of them even encircled tumor cells. There were many varicosities aligned on the nerve fibers like beads. They were also closely related to tumor cells. In the co-culture group, about 63 %and 67 % of DRG co-cultured with esophageal and cardiac tumor blocks respectively extended enormous processes,especially on the side adjacent to the tumor, whereas in the control group (without tumor blocks), no processes grew out.CONCLUSION: Esophageal and cardiac carcinomas may be innervated by peptidergic nerve fibers, and they can induce neurons of DRG to extend processes in vitro. | Shuang-Hong Lü Yan Zhou Hai-Ping Que Shao-Jun Liu Department of Neurobiology, Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China | 2003 | World Journal of Gastroenterology2003，9，3： | 9 |
| 2 | Antioxidant properties of water and ethanol extract from hot air-dried and freeze-dried daylily flowers 显示文摘 | Mao L Pan X Que F | 2006 | Eur Food Res & Tech2006，222，34： | 1 |
| 3 | Enhanced bioavailability of silymarin by self-mieroemulsifying drug delivery system 显示文摘 | Wu W Wang Y Que L | 2006 | Eur J Pharm Biopharm2006，63，： | 1 |
| 4 | In Situ Dynamics of Microbial Communities during Decomposition of Wheat,Rape,and Alfalfa Residues显示文摘 | Pascault N Cécillon L Mathieu O Hénault C Sarr A Lév(e)que J Fatty P Ranjard L Maron PA | | 0，，04： | 1 |
| 5 | Antioxidant activities of five Chineserice wines and the involvement of phenolic compounds显示文摘 | Que F Mao L C Pan X | 2006 | Food Research International2006，39，： | 1 |
| 6 | Whole mitochondrial genome screening in maternally inherited non syndromic hearing impairment using a microarray resequencing mitochondrial DNA chip显示文摘 | Leve que M Marlin S Jonard L | 2007 | Eur J Hum Genet2007，15，： | 1 |
| 7 | A critical review of larch hybridization and its incidence on breeding strategies 显示文摘 | Pques L E | 1989 | Ann Sci For1989，46，： | 1 |
| 8 | Antioxidant activities of five Chinese rice wines and the involvement of phenolic compounds 显示文摘 | Que F Mao L C Pan X | 2006 | Food Research International2006，39，5： | 1 |
| 9 | The effects of neutron irradiation on the oxygen precipitation in Czochralski-silicon, 显示文摘 | LI Y XI GUO H Y LIU B D LIU T J HAO Q Y LIU C C YANG D R QUE D L | 2003 | J Cryst Growth2003，253，： | 1 |
| 10 | Characterization and limits of a cold-atom sagnac interferometer显示文摘 | Gauguet A Canuel B Lévèque T et a1 | | 0，，06： | 1 |
| 11 | Two-state reactivity in alkane hydroxylation by non-heme iron- oxo complexes 显示文摘 | HIRAO H KUMAR D QUE L | 2006 | Journal of the American Chemical Society2006，128，26： | 1 |
| 12 | Texturization of monocrystalline silicon with tribasic sodium phosphate显示文摘 | Xi Z Q Yang D R Que D L | 2003 | Sol Energy Mater Sol Cells2003，77，： | 1 |
| 13 | Antioxidant properties of Chinese yellow wine, its concentrate and volatiles 显示文摘 | Que F Mao L C Zhu C G | 2006 | LWT - Food Science and Technology2006，39，2： | 1 |
| 14 | Metals in neurobiology:probing their chemistry and biology with molecular imaging 显示文摘 | Que E L Domaille D W Chang C J | 2008 | Chem Rev2008，108，10： | 1 |
| 15 | Enhanced bioavailability Of silymarin by self-microemulsifying drug delivery system 显示文摘 | WU W WANG Y QUE L | 2006 | Eur J Pharm Biopharm2006，63，3： | 1 |
| 16 | Effects of nitrogen on grown-in oxygen precipitates in large diameter Czochralski silicon 显示文摘 | YU X G YANG D R YANG J S MAX Y LI L B QUE D L | 2003 | Chin J Semicond2003，24，1： | 1 |
| 17 | Molecular variation of Sporisorium scitamineum in Mainland China revealed by RAPD and SRAP markers显示文摘 | Que Y X Xu L P Lin J W | 2012 | Plant Disease2012，96，10： | 1 |
| 18 | Universal newborn hearing screening in the Champagne-Ardenne region:a 4-year follow-up after early diagnosis of hearing impairment显示文摘 | LANGAGNE T LVQUE M SCHMIDT P ET AL | 2010 | Int J Pediatr Otorhinolaryngol2010，74，： | 1 |
| 19 | Hydrodynamic and mass transfer efficiency of ceramic foam packing applied to distillation显示文摘 | LVQUE J ROUZINEAU D PRVOST M | 2009 | Chemical Engineering Science2009，64，11： | 1 |
| 20 | Optical and microstructural properties of sol-gel derived titania/organically modified silane thin films 显示文摘 | Que W x Zhou Y Lam Y L | 2000 | Thin Solid Films2000，358，12： | 1 |
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