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| 1 | Pertuzumab in combination with trastuzumab and chemotherapy for Chinese patients with HER2-positive metastatic gastric or gastroesophageal junction cancer:a subpopulation analysis of the JACOB trial显示文摘Background:The JACOB trial(NCT01774786)was a double-blinded,placebo-controlled,randomized,multicenter,international,phase III trial evaluating the efficacy and safety of adding pertuzumab to trastuzumab and chemo-therapy in first-line treatment of human epidermal growth factor receptor 2(HER2)-positive metastatic gastric cancer/gastroesophageal junction cancer(GEJC).The aim of this analysis was to investigate efficacy and safety outcomes in the Chinese subpopulation from the JACOB trial.Methods:This post hoc subpopulation analysis included all patients recruited in China's Mainland(n=163;20.9%)between June 2013 and January 2016.The patients were randomly assigned in a 1:1 ratio to receive pertuzumab plus trastuzumab and chemotherapy(pertuzumab group;n=82)or placebo plus trastuzumab and chemotherapy(con-trol group;n=81).Intravenous pertuzumab(840 mg)and trastuzumab(8 mg/kg loading and 6 mg/kg maintenance doses)were given every 3 weeks until disease progression or unacceptable toxicity.Chemotherapy was given as per standard regimens/doses of capecitabine or 5-fluorouracil plus cisplatin.The primary endpoint was overall survival(OS);secondary efficacy endpoints included progression-free survival(PFS),and overall objective response rate(ORR).Results:The median OS was 18.7 months in the pertuzumab group and 16.1 months in the control group(hazard ratio[HR]0.75;95%confidence interval[CI]0.49 to 1.14).The median PFS was 10.5 and 8.6 months in the pertuzumab and control groups,respectively(HR 0.85;95%CI 0.60 to 1.21),and the median ORRs were 68.9%and 55.7%,respectively.The treatment effect in this Chinese subpopulation showed consistency with that in the global ITT population with numerically lower HR for OS and PFS compared with the control group.The safety profiles of the pertuzumab and control groups in this Chinese subpopulation analysis were generally comparable.The most common grade 3-5adverse events were neutropenia,anemia,and leukopenia.However,due to the nature of being a post hoc subgroup analysis,the results presented here are descriptive only and need to be interpreted with caution.Conclusions:OS and PFS were numerically improved by adding pertuzumab to trastuzumab and chemotherapy as first-line treatment in Chinese HER2-positive gastric cancer/GEJC patients,and this regimen demonstrated an acceptable safety profile. | Tianshu Liu Yanru Qin Jin Li Ruihua Xu Jianming Xu Shujun Yang Shukui Qin Yuxian Bai Changping Wu Yixiang Mao Haiyan Wu Yilin Ge Lin Shen | 2019 | Cancer Communications2019，39，1： | 6 |
| 2 | Resveratrol derivative BTM-0512 mitigates obesity by promoting beige remodeling of subcutaneous preadipocytes显示文摘 | Qingqing Li Kuansong Wang Yipeng Ma Chunxiang Qin Changsheng Dong Ping Jin Yan Wu Xiaoming Xiong Niansheng Li Changping Hu Jun Peng Zhichun Yang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，4： | 1 |
| 3 | 5-11 Conceptual Design of Sub-critical Reactor of CADS Project显示文摘China Initiative Accelerator Driven System (CIADS) proposed by the Chinese Academy of Sciences which is one of the twelve Major National Scientific and Technological Infrastructures has been approved by National Development and Reform Commission of China, and supposed to be the first principle prototype ADS experimental facility in the world. | Gu Long Li Jinyang Wang Dawei Fan Qing Qin Changping Liu Lu Zhu Yanlei Yu Rui Chai Yilin | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 4 | 5-15 Recent Progress in Reactor Physics Group at IMP显示文摘In 2014, some of achievements have been obtained in reactor physics group at IMP supported by the Strategictechnology pilot projects of CAS.The reactor physics group was one of the major groups involved in the MeAWaT project in PSI in Switzerland,whose aim will manufacture one single prototype nuclear fuel with minor actinide elements. In this project, ourgroup has mainly focus on neutronics design and thermohydraulic analysis for the new type of nuclear fuel. Duringthe work in this project, one new relationship for the pressure drop of wire-wrapped fuel bundles has been proposed.The comparison result between Cheng and Todreas' correlations has been showed as Fig. 1 as following. | Gu Long Fan Qin Li Jinyang Wang Dawei Qin Changping | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 5 | Transcriptomic and metabolomic analysis provides insights into lignin biosynthesis and accumulation and differences in lodging resistance in hybrid wheat显示文摘The use of hybrid wheat is one way to improve the yield in the future.However,greater plant heights increase lodging risk to some extent.In this study,two hybrid combinations with differences in lodging resistance were used to analyze the stem-related traits during the filling stage,and to investigate the mechanism of the difference in lodging resistance by analyzing lignin synthesis of the basal second internode(BSI).The stem-related traits such as the breaking strength,stem pole substantial degree(SPSD),and rind penetration strength(RPS),as well as the lignin content of the lodging-resistant combination(LRC),were significantly higher than those of the lodgingsensitive combination(LSC).The phenylpropanoid biosynthesis pathway was significantly and simultaneously enriched according to the transcriptomics and metabolomics analysis at the later filling stage.A total of 35 critical regulatory genes involved in the phenylpropanoid pathway were identified.Moreover,42%of the identified genes were significantly and differentially expressed at the later grain-filling stage between the two combinations,among which more than 80%were strongly up-regulated at that stage in the LRC compared with LSC.On the contrary,the LRC displayed lower contents of lignin intermediate metabolites than the LSC.These results suggested that the key to the lodging resistance formation of LRC is largely the higher lignin synthesis at the later grain-filling stage.Finally,breeding strategies for synergistically improving plant height and lodging resistance of hybrid wheat were put forward by comparing the LRC with the conventional wheat applied in large areas. | Weibing Yang Shengquan Zhang Qiling Hou Jiangang Gao Hanxia Wang Xianchao Chen Xiangzheng Liao Fengting Zhang Changping Zhao Zhilie Qin | 2024 | Journal of Integrative Agriculture2024，23，4： | 0 |
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