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| 1 | Transplant outcomes of 100 cases of living-donor ABO-incompatible kidney transplantation显示文摘Background:Although ABO-incompatible(ABOi)kidney transplantation(KT)has been performed successfully,a standard preconditioning regimen has not been established.Based on the initial antidonor ABO antibody titers,an individualized preconditioning regimen is developed,and this study explored the efficacy and safety of the regimen.Methods:From September 1,2014,to September 1,2020,we performed 1668 consecutive living-donor KTs,including 100 ABOi and 1568 ABO-compatible(ABOc)KTs.ABOi KT recipients(KTRs)with a lower antibody titer(≤1:8)were administered oral immunosuppressive drugs(OIs)before KT,while patients with a medium titer(1:16)received OIs plus antibody-removal therapy(plasma exchange/double-filtration plasmapheresis),patients with a higher titer(≥1:32)were in addition received rituximab(Rit).Competing risk analyses were conducted to estimate the cumulative incidence of infection,acute rejection(AR),graft loss,and patient death.Results:After propensity score analyses,100 ABOi KTRs and 200 matched ABOc KTRs were selected.There were no significant differences in graft and patient survival between the ABOi and ABOc groups(P=0.787,P=0.386,respectively).After using the individualized preconditioning regimen,ABOi KTRs showed a similar cumulative incidence of AR(10.0%vs.10.5%,P=0.346).Among the ABOi KTRs,the Rit-free group had a similar cumulative incidence of AR(P=0.714)compared to that of the Rittreated group.Multivariate competing risk analyses revealed that a Rit-free regimen reduced the risk of infection(HR:0.31;95%CI:0.12–0.78,P=0.013).Notably,antibody titer rebound was more common in ABOi KTRs receiving a Rit-free preconditioning regimen(P=0.013)than those receiving Rit.ABOi KTRs with antibody titer rebound had a 2.72-fold risk of AR(HR:2.72,95%CI:1.01–7.31,P=0.048).ABOi KTRs had similar serum creatinine and estimated glomerular filtration rate compared to those of ABOc KTRs after the first year.Conclusions:An individualized preconditioning regimen can achieve comparable graft and patient survival rates in ABOi KT with ABOc KT.Rit-free preconditioning effectively prevented AR without increasing the risk of infectious events in those with lower initial titers;however,antibody titer rebound should be monitored. | Saifu Yin Qiling Tan Youmin Yang Fan Zhang Turun Song Yu Fan Zhongli Huang Tao Lin Xianding Wang | 2022 | Chinese Medical Journal2022，135，19： | 7 |
| 2 | Non-Darcy flow seepage characteristics of saturated broken rocks under compression with lateral constraint显示文摘sing an MTS816.03 test system and self-designed seepage apparatus,seepage tests of saturated broken rocks were conducted,and the influence of lithology,axial stress,grain size distribution and loading rate on seepage characteristics was analyzed.The results show that:(1) Under the same axial stress(12 MPa)the permeability of different lithologic samples increases in the order:gangue < mudstone < sand stone < limestone.The permeability of gangue is 3 magnitudes lower than that of limestone.The absolute value of the non-Darcy coefficient β increases in the order:limestone < sandstone < mudstone < gangue The non-Darcy coefficient β of limestone,which is positive,is 5 magnitudes lower than that of gangue.(2)With increasing axial stress,the permeability of saturated broken sandstone decreases,and the absolute value of the non-Darcy coefficient β increases.After the axial stress exceeds 12 MPa,the curves of perme ability and non-Darcy coefficient β all tend to be stable.(3) With increasing Talbol power exponent,the permeability increases,and the absolute value of the non-Darcy coefficient β decreases.(4) With increas ing loading,the permeability increases,and the absolute value of the non-Darcy coefficient β decreases When the loading rate is 0.5 kN/s,the non-Darcy coefficient β is positive. | Yu Bangyong Chen Zhanqing Ding Qile Wang Luzhen | 2016 | International Journal of Mining Science and Technology2016，26，6： | 2 |
| 3 | Self-targeting visualizable hyaluronate nanogel for synchronized intracellular release of doxorubicin and cisplatin in combating multidrug-resistant breast cancer显示文摘Multidrug-resistance(MDR)featuring complicated and poorly defined mechanisms is a major obstacle to the success of cancer chemotherapy in the clinic.Compound nanoparticles comprising multiple cytostatics with different mechanisms of action are commonly developed to tackle the multifaceted nature of clinical MDR.However,the different pharmacokinetics and release profiles of various drugs result in inconsistent drug internalization and suboptimal drug synergy at the tumor sites.In the present study,a type of self-targeting hyaluronate(HA)nanogels((CDDPH)^ANG/DOX)to reverse drug resistance through the synchronized pharmacokinetics,intratumoral distribution,and intracellular release of topoisomerase II inhibitor doxorubicin(DOX)and DNA-crosslinking agent cisplatin(CDDP)is developed.With prolonged circulation time and enhanced intratumoral accumulation in vivo,(CDDP)^HANG/DOX shows efficient drug delivery into the drug-resistant MCF-7/ADR breast cancer cells and enhanced antitumor activity.Besides,fluorescence imaging of DOX combined with the micro-computed tomography(micro-CT)imaging of CDDP facilitates the visualization of this combination tumor chemotherapy.With visualizable synchronized drug delivery,the self-targeting in situ crosslinked nanoplatform may hold good potential in future clinical therapy of advanced cancers. | Wen Ma Qiling Chen Weiguo Xu Meng Yu Yuanyuan Yang Binhua Zou Yu Shrike Zhang Jianxun Ding Zhiqiang Yu | 2021 | Nano Research2021，14，3： | 1 |
| 4 | Design of a novel mitochondria targetable turn-on fluorescence probe for hydrogen peroxide and its two-photon bioimaging applications显示文摘Considering that hydrogen peroxide(H2O2)plays significant roles in oxidative stress,the cellular signal transduction and essential biological process regulation,the detection and imaging of H2O2 in living systems undertakes critical responsibility.Herein,we have developed a novel two-photon fluorescence turn on probe,named as Pyp-B for mitochondria H2O2 detection in living systems.Selectivity studies show that probe Pyp-B exhibit highly sensitive response toward H2O2 than other reactive oxygen species(ROS)and reactive nitrogen species(RNS)as well as biologically relevant species.The fluorescence colocalization studies demonstrate that the probe can localize in the mitochondria solely.Furthermore,as a bio-compatibility molecule,the highly selective and sensitive of fluorescence probe Pyp-B have been confirmed by its cell imaging application of H2O2 in living A549 cells and zebrafishes under the physiological conditions. | Kangnan Wang Wen Ma Yuchun Xu Xin Liu Gui Chen Meng Yu Qiling Pan Chaobo Huang Xiaochuan Li Qingchun Mu Yongbing Sun Zhiqiang Yu | 2020 | Chinese Chemical Letters2020，31，12： | 1 |
| 5 | Catalytic graphitization of carbon fibers with electrodeposited Ni-B alloy coating显示文摘 | Zhou Haihui Yu Qiang Peng Qiling | 2008 | Materials Chemistry and Physics2008，110，： | 1 |
| 6 | Identification and functional characterization of female antennae-biased odorant receptor 23 involved in acetophenone detection of the Indian meal moth Plodia interpunctella显示文摘The Indian meal moth,Plodia interpunctella(Lepidoptera:Pyralidae),a globally distributed storage pest,relies on odors that are emitted from stored foods to select a suitable substrate for oviposition.However,the molecular mechanism underlying the chemical communication between P.interpunctella and its host remains elusive.In this study,130 chemosensory genes were identified from the transcriptomes of 7 P.interpunctella tissues,and the quantitative expression levels of all 56 P.interpunctella odorant receptor genes(PintORs)were validated using real-time quantitative polymerase chain reaction.The functional characteristics of 5 PintORs with female antennae-biased expression were investigated using 2-electrode voltage clamp recordings in Xenopus laevis oocytes.PintOR23 was found to be specifically tuned to acetophenone.Acetophenone could elicit a significant electrophysiological response and only attracted mated females when compared with males and virgin females.In addition,molecular docking predicted that the hydrogen bonding sites,TRP-335 and ALA-167,might play key roles in the binding of PintOR23 to acetophenone.Our study provides valuable insights into the olfactory mechanism of oviposition substrate detection and localization in P.interpunctella and points toward the possibility of developing eco-friendly odorant agents to control pests of stored products. | Qi Chen Xiaoyan Zhu Guoqing Kang Qiling Yu Qingxin Liu Lin Du Yi Yang Xinyu He Ying Zhao Junjie Zhang Ying Hu Bingzhong Ren | 2024 | Insect Science2024，31，1： | 0 |
| 7 | Clinical Observation on the Treatment of Diabetic Kidney Disease with Damp-heat Stasis Syndrome in Clinical Proteinuria Stage by Kunkui Kidney Preserving Paste显示文摘[Objectives]To evaluate the clinical efficacy and safety of Kunkui Kidney Preserving Paste in the treatment of diabetic kidney disease(DKD)patients with damp-heat stasis syndrome in the clinical proteinuria stage.[Methods]Retrospective analysis was made on 30 patients with DKD who were diagnosed with damp-heat stasis syndrome in the clinical proteinuria stage from March 2021 to March 2023 in Jiangsu Province Hospital of Chinese Medicine,and who took Kunkui Kidney Preserving Paste continuously for six months.The urinary albumin/creatinine ratio(UACR),urinary complement C3,and urea nitrogen(BUN)of DKD patients before and after treatment were compared,and estimated glomerular filtration rate(eGFR),blood creatinine(Scr),and cystatin C(CysC)were estimated,and the therapeutic effects on renal function and urinary protein were evaluated.[Results]After treatment,UACR significantly decreased(P<0.01),and urinary complement C3 and Scr decreased(P<0.05),while other indicators showed no significant statistical difference(P>0.05).In terms of evaluating the efficacy of urinary protein therapy,8 cases showed recent relief;8 cases showed significant effect;9 cases were effective,and 5 cases were invalid after treatment,with a total effective rate of 83.33%.In terms of renal function efficacy evaluation,8 cases showed significant effect;4 cases were effective;11 cases were stable,and 7 cases were invalid,with a total effective rate of 76.67%.In the safety evaluation,there were no obvious adverse reactions.[Conclusions]The Kunkui Kidney Preserving Past has significant clinical efficacy and safety in treating DKD patients with damp-heat stasis syndrome in the clinical proteinuria period.It has significant advantages in reducing urinary protein and protecting renal function,which is worthy of clinical promotion. | Ying TAN Qiling ZHANG Juan CHEN Xu YU Qianhua YAN Jiangyi YU | 2024 | Medicinal Plant2024，15，1： | 0 |
| 8 | Resilience assessment model for urban public transportation systems based on structure and function显示文摘Urbanization and the increasing frequency of extreme climates affect the sustainability of urban public transportation systems,and improving resilience is one of the primary directions for sustainable development.To scientifically assess the resilience of urban public transportation systems,a resilience assessment model based on structure and function is established in this study.This model mathematically quantifies and simulates the structural and functional changes in public transportation systems under disruption scenarios and provides a comprehensive assessment of six abilities:1)structural resistance,2)structural recoverability,3)functional resistance,4)functional recoverability,5)passenger adaptability,and 6)management adaptability.Depending on the initial failure stations,this model can simulate the resilience of a public transportation system under various scenarios.This model is applied to assess the resilience of public transportation systems in a provincial capital city under an equipment failure scenario.The results show that the impact of equipment failure on resilience varies according to the metro lines,and improvement strategies for functional recoverability and management adaptability are proposed.The weaknesses in the resilience of urban public transportation systems can be identified using the proposed model,which helps provide strategies for improving the capacity to face perturbations. | Changkun Chen Fan He Rongfu Yu Siqi Wang Qile Dai | 2023 | Journal of Safety Science and Resilience2023，4，4： | 0 |
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