3篇
您的检索式：作者名="Qiling WEN"
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| 1 | Self-targeting visualizable hyaluronate nanogel for synchronized intracellular release of doxorubicin and cisplatin in combating multidrug-resistant breast cancer显示文摘Multidrug-resistance(MDR)featuring complicated and poorly defined mechanisms is a major obstacle to the success of cancer chemotherapy in the clinic.Compound nanoparticles comprising multiple cytostatics with different mechanisms of action are commonly developed to tackle the multifaceted nature of clinical MDR.However,the different pharmacokinetics and release profiles of various drugs result in inconsistent drug internalization and suboptimal drug synergy at the tumor sites.In the present study,a type of self-targeting hyaluronate(HA)nanogels((CDDPH)^ANG/DOX)to reverse drug resistance through the synchronized pharmacokinetics,intratumoral distribution,and intracellular release of topoisomerase II inhibitor doxorubicin(DOX)and DNA-crosslinking agent cisplatin(CDDP)is developed.With prolonged circulation time and enhanced intratumoral accumulation in vivo,(CDDP)^HANG/DOX shows efficient drug delivery into the drug-resistant MCF-7/ADR breast cancer cells and enhanced antitumor activity.Besides,fluorescence imaging of DOX combined with the micro-computed tomography(micro-CT)imaging of CDDP facilitates the visualization of this combination tumor chemotherapy.With visualizable synchronized drug delivery,the self-targeting in situ crosslinked nanoplatform may hold good potential in future clinical therapy of advanced cancers. | Wen Ma Qiling Chen Weiguo Xu Meng Yu Yuanyuan Yang Binhua Zou Yu Shrike Zhang Jianxun Ding Zhiqiang Yu | 2021 | Nano Research2021，14，3： | 1 |
| 2 | Design of a novel mitochondria targetable turn-on fluorescence probe for hydrogen peroxide and its two-photon bioimaging applications显示文摘Considering that hydrogen peroxide(H2O2)plays significant roles in oxidative stress,the cellular signal transduction and essential biological process regulation,the detection and imaging of H2O2 in living systems undertakes critical responsibility.Herein,we have developed a novel two-photon fluorescence turn on probe,named as Pyp-B for mitochondria H2O2 detection in living systems.Selectivity studies show that probe Pyp-B exhibit highly sensitive response toward H2O2 than other reactive oxygen species(ROS)and reactive nitrogen species(RNS)as well as biologically relevant species.The fluorescence colocalization studies demonstrate that the probe can localize in the mitochondria solely.Furthermore,as a bio-compatibility molecule,the highly selective and sensitive of fluorescence probe Pyp-B have been confirmed by its cell imaging application of H2O2 in living A549 cells and zebrafishes under the physiological conditions. | Kangnan Wang Wen Ma Yuchun Xu Xin Liu Gui Chen Meng Yu Qiling Pan Chaobo Huang Xiaochuan Li Qingchun Mu Yongbing Sun Zhiqiang Yu | 2020 | Chinese Chemical Letters2020，31，12： | 1 |
| 3 | Illumination and regolith temperature at China's next candidate lunar landing site Shackleton crater显示文摘This study focuses on the illumination and temperature at China’s next lunar candidate landing site Shackleton crater.We used the NASA’s SPICE system to evaluate the terrain obscuration effect on real-time illumination;the resulting illumination map resembles previous studies,validating the methodologies used in our study.In addition,we estimated an accumulated illumination map for the period of likely rover movement.The map indicates the illuminated inner wall of the Shackleton crater is close to 27%of the whole,meaning that the rover will likely receive solar radiation during its movement.Using the real-time illumination and the distributed 1-D thermal diffusion model,we continuously evaluated the regolith temperature for more than 20 years to stabilize the temperature,and selected the temperature of the end time as the initial value used in a thermal study set for July 20,2023 and May 8,2027.Our results indicate the temperature in the permanent shadow region remains nearly constant,thus validating the stability of our estimated initial temperature.Our results also indicate that the surface temperature is more sensitive to transient illumination,but the subsurface temperature is more likely to be associated with the accumulated illumination.This difference indirectly implies that the conductivity of the lunar regolith is inefficient.The locations receiving more solar radiation show a temperature larger than the threshold(~112 K)of ice stability.The permanently shadowed regions can be as cold as 25 K,and such extreme coldness is a hazard to the rover.There are suitable temperature locations which have a warm surface but cold subsurface to preserve water ice.To further ensure normal rover movement,we provided a map of suitable temperature sites and found that these locations exist not only in the Shackleton crater’s inner wall,but also outside the crater.We suggested four trade-off sampling sites with suitable temperatures and gradual slopes. | Zhen ZHONG Jianguo YAN Huaiyu HE Qiling WEN Deyun LIU Jean-Pierre BARRIOT | 2023 | Science China Earth Sciences2023，66，2： | 0 |
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