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| 1 | Comparison of inhaled milrinone, nitric oxide and prostacyclin in acute respiratory distress syndrome显示文摘AIM To evaluate the safety and efficacy of inhaled milrinone in acute respiratory distress syndrome(ARDS).METHODS Open-label prospective cross-over pilot study where fifteen adult patients with hypoxemic failure meeting standard ARDS criteria and monitored with a pulmonary artery catheter were recruited in an academic 24-bed medico-surgical intensive care unit. Random sequential administration of i NO(20 ppm) or nebulized epoprostenol(10 μg/mL) was done in all patients. Thereafter, inhaled milrinone(1 mg/mL) alone followed by inhaled milrinone in association with inhaled nitric oxide(iN O) was administered. A jet nebulization device synchronized with the mechanical ventilation was use to administrate the epoprostenol and the milrinone. Hemodynamic measurements and partial pressure of arterial oxygen(PaO_2) were recorded before and after each inhaled therapyadministration.RESULTS The majority of ARDS were of pulmonary cause(n = 13) and pneumonia(n = 7) was the leading underlying initial disease. Other pulmonary causes of ARDS were: Post cardiopulmonary bypass(n = 2), smoke inhalation injury(n = 1), thoracic trauma and pulmonary contusions(n = 2) and aspiration(n = 1). Two patients had an extra pulmonary cause of ARDS: A polytrauma patient and an intra-abdominal abscess Inhaled nitric oxide, epoprostenol, inhaled milrinone and the combination of inhaled milrinone and i NO had no impact on systemic hemodynamics. No significant adverse events related to study medications were observed. The median increase of PaO 2 from baseline was 8.8 mmH g [interquartile range(IQR) = 16.3], 6.0 mm Hg(IQR = 18.4), 6 mm Hg(IQR = 15.8) and 9.2 mm Hg(IQR = 20.2) respectively with i NO, epoprostenol, inhaled milrinone, and i NO added to milrinone. Only i NO and the combination of inhaled milrinone and i NO had a statistically significant effect on PaO 2. CONCLUSION When comparing the effects of inhaled NO, milrinone and epoprostenol, only NO significantly improved oxygenation. Inhaled milrinone appeared safe but failed to improve oxygenation in ARDS. | Martin Albert Daniel Corsilli David R Williamson Marc Brosseau Patrick Bellemare Stéphane Delisle Anne QN Nguyen France Varin | 2017 | World Journal of Critical Care Medicine2017，6，1： | 4 |
| 2 | Study on Characteristics of Steady Flow Condensation Heat Transfer in a Tube under Zero-Gravitation显示文摘StudyonCharacteristicsofSteadyFlowCondensationHeatTransferinaTubeunderZero-GravitationQnWei(HarbinInstituteofTechnology,Harbi... | Qn Wei(Harbin Institute of Technology, Harbin 150001 China)Hou Zengqi Zhang Jiaxun (Chinese Academy of Space Technology, Beijing 100086, China) | 1996 | Journal of Thermal Science1996，5，3： | 2 |
| 3 | Relative frequency and survival of primary cutaneous lymphomas: a retrospective analysis of 98 patients显示文摘 | Liu J Liu YH Jin HZ Ma DL Qu T Wang T S un QN Yu X | 2014 | Chinese Medical Journal2014，，4： | 2 |
| 4 | Dietary sodium and potassium,socioeconomic status,and blood pressure in a Chinese population显示文摘 | Tian HG HU G Dong QN | 1996 | Appetite1996，26，3： | 1 |
| 5 | PPAR alpha activator fenofibrate inhibits myocardial inflammation and fibrosis in angiotensin Ⅱ-infused rats显示文摘 | Diep QN Benkirane K Amiri F | | 0，，： | 1 |
| 6 | The enhancing effect of synthetical borneol on the absorption of tetramethylpyrazinephosphate in mouse显示文摘 | Xiao YY Ping QN Chen ZP | 2007 | International Journal of Pharrnaceutics2007，337，2： | 1 |
| 7 | Prodrugs of scutellarin: ethyl, benzyl and N,N-diethylglycolamide ester synthesis, physicochemical properties, intestinal metabolism and oral bioavailability in the rats 显示文摘 | Cao F Guo JX Ping QN | 2006 | Eur JPharm Sci2006，29，5： | 1 |
| 8 | Deletion of M2 gene open reading frames 1 and 2 of human metapneumovirus: effects on RNA synthesis, attenuation, and immunogenicity 显示文摘 | Buchholz UJ Biacchesi S Pham QN | 2005 | J Vir- ol2005，79，11： | 1 |
| 9 | Preparation of breviscapine nanosuspension and its pharmacokinetic behavior in rats 显示文摘 | She ZY Ke X Ping QN | 2007 | Chin J Nat Med Jan2007，5，1： | 1 |
| 10 | Long-term effects of the PPAR gamma activator pioglitazone on cardiac inflammation in stroke-prone spontaneously hypertensive rats 显示文摘 | Diep QN Amiri F Benkirane K | 2004 | Can J Physi olPharmacol2004，82，11： | 1 |
| 11 | Redox-sensitive protein phosphatase activity regulates the phosphorylation state of p38 protein kinase in primary astrocyte culture 显示文摘 | Robinson KA Stewart CA Pye QN | 1999 | J Neurosci Res1999，55，6： | 1 |
| 12 | In vitro activities ot posaconazole,itraconazole,voriconazole,amphotericin B,and fluconazole against 37 clinical isolates of zygomycetes显示文摘 | Sun QN Fothergill AW McCarthy DI | 2002 | Antimicrob Agents Chemother2002，46，： | 1 |
| 13 | Resveratrol: potential as anticancer agent 显示文摘 | Aluyen JK Ton QN Tran T | 2012 | J Diet Suppl2012，9，1： | 1 |
| 14 | Preparation of 99mTc-C60(OH) x and its biodistribution studies 显示文摘 | Li QN Xiu Y Zhang XD | 2002 | Nuclear medicine and Biology2002，29，6： | 1 |
| 15 | Association between baseline iris thickness and prophylactic laser peripheral iri- dotomy outcomes in primary angle-closure suspects 显示文摘 | Lee RY Kasuga T Cui QN | 2014 | Ophthalmology2014，121，： | 1 |
| 16 | Effect of AT(1) receptor blockade on cardiac apoptosis in angiotensin Ⅱ-induced hypertension显示文摘 | Diep QN EI Mabrouk M Yre P | 2002 | Am J Physiol Heart Circ Physiol2002，282，5： | 1 |
| 17 | PPAR-gamma inhibits Ang Ⅱ -induced cell growth via SHIP2 and 4E-BP1 显示文摘 | Benkirane K Amiri F Diep QN | 2006 | Am J Physiol Heart Circ Physiol2006，290，1： | 1 |
| 18 | Increased expression of peroxisome proliferator-activated receptor-alpha and -gamma in blood vessels of spontaneously hypertensive rats 显示文摘 | Diep QN Schiffrin EL | 2001 | Hypertension2001，38，2： | 1 |
| 19 | Bile duct carcinoma:trends in treatment in the nineties显示文摘 | Reed QN Jr Vitale GC Martin R | 2000 | Am Surg2000，66，8： | 1 |
| 20 | PPARa activator effects on Ang II-induced vascular oxidative stress and inflammation显示文摘 | Diep QN Amiri F Touyz RM Cohn JS Endemann D Neves MF | 2002 | Hypertension2002，40，： | 1 |
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