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| 1 | Flavone from Zhongjiefeng(Herba Sarcandrae Glabrae) inhibits platelet apoptosis in immune-induced bone marrow failure through mitochondrial pathway显示文摘OBjECTIVE: To investigate the effect of Flavone from Zhongjiefeng(Herba Sarcandrae Glabrae) on the platelet number in immune-induced bone marrow failure(BMF) and its mechanism of mitochondrial apoptotic pathway.METHODS: Immune-induced BMF model, established in mice, was randomly divided into four groups: normal control group without BMF, BMF control group, cyclosporine(CSA) group and flavone group(n = 10 in each group). Mice were given0.027 g/kg cyclosporine or 0.2 g/kg flavone lavage daily in either the cyclosporine or flavone group respectively. Platelet count, mitochondrial transmembrane potential(ΔΨm), cytochrome C(Cyt C), phosphatidylserine(PS), changes of calcium ion(Ca^(2+)),and protein expression of mitochondrial apoptotic pathway including B-cell lymphoma-2(bcl-2) Homologous Antagonist-Killer Protein(Bak), bcl-2-associated X protein(Bax), caspase-3, caspase-8, and caspase-9 were examined and compared.RESULTS: Compared with the normal control group, the BMF group had significantly lower levels of platelet count, ΔΨm, and expressions of caspase family proteins as well as higher levels of Cyt C, PS,Ca^(2+), and expressions of Bak and Bax(all P < 0.05).Compared with the BMF group, the CSA and flavone groups had significantly higher ΔΨm and expressions of caspase family proteins(all P < 0.05)whereas the levels of Cyt C, PS, Ca^(2+), and expressions of Bak and Bax were reduced(all P < 0.05).More importantly, the flavone group had higher levels of Cyt C, Ca^(2+)and expressions of Bak and Bax compared with the CSA group(all P < 0.05), while the levels of PS and caspase family proteins were reduced(all P < 0.05).CONCLUSION: Flavone from Zhongjiefeng(Herba Sarcandrae Glabrae) significantly increases the platelet number and prevents its apoptosis through mitochondrial pathway. | Jiang Yiling Zheng Qin Zhang Aiping Cui Lele Xia Lemin Luo Meihong | 2017 | Journal of Traditional Chinese Medicine2017，37，5： | 2 |
| 2 | No tillage outperforms conventional tillage under arid conditions and following fertilization显示文摘Reduced tillage practices present a tool that could sustainably intensify agriculture.The existing literature,however,lacks a consensus on how and when reduced tillage practices should get implemented.We reanalyzed here an extensive dataset comparing how regular tillage practices(i.e.,conventional tillage)impacted yield of eight crops compared to stopping tillage altogether(i.e.,no-tillage practice).We observed that aridity and fertilization favored no tillage over conventional tillage whereas conventional tillage performed better under high fertility settings.We further show that the responses are consistent across the crops.Our reanalysis complements the original and fills a gap in the literature questioning the conditions under which reducing tillage presents a viable alternative to common tillage practices. | Stavros D.Veresoglou Junjiang Chen Xuheng Du Qi Fu QingLiu Geng Chenyan Huang Xilin Huang Nan Hu Yiming Hun Guolin C.Li Zhiman Lin Zhiyu Ma Yuyi Ou Shuo Qi Haitian Qin Yingbo Qiu Xibin Sun Ye Tao YiLing Tian Jie Wang Lingxiao Wu Ziwei Wu Siqi Xie Ao Yang Dan Yang Chen Zeng Ying Zeng RuJie Zhang | 2023 | Soil Ecology Letters2023，5，1： | 1 |
| 3 | An Empirical Analysis of Ag- gregation Level on Gansu's Modem Service Industry 显示文摘 | Jin Mei Liu Yiling Qin Hongyi | 2011 | Energy Procedia2011，5，： | 1 |
| 4 | The roles of phosphate in shaping the structure and dynamics of Antarctic soil microbiomes显示文摘One major consequence of global warming in the Antarctic region is increased ice-free zones.Subsequent colonization of these ice-free areas by penguins alters their biogeochemistry,with one prominent example being elevation of inorganic phosphate concentrations around feces depositions.The complex soil biochemistry in the region makes it difficult to define the causal factors of these changes using common research approaches.Here,we addressed the effects of phosphate alone on microbiome structure and dynamics over time by adding external phosphate to selected soils in the Antarctic region.We then analyzed the soil bacterial community composition and diversity using 16S rRNA amplicon sequencing and compared these data with phosphate levels.Parallel geochemical analysis revealed changes in nine soil geochemical factors upon phosphate addition,all of which were relevant to microbiome structure,with soil pH showing the highest correlation.Links between geochemical factors and composition were identified,as were interactions between bacterial taxa.Additionally,Sphingobacteriia,Sphingobacteriales and Chitinophagaceae were found to be more abundant in phosphate-treated soils.Co-occurrence network analysis revealed significantly increased levels of associations in all major network properties over time after phosphate supplementation.Therefore,we conclude phosphate addition has diverse effects on Antarctic soil microbiomes. | TAN Jiankang CAO Huansheng LIU Li QIN Yiling LIU Feng John CAVA YIN Xiaofei SHEN Jihong WANG Nengfei | 2023 | Advances in Polar Science2023，34，1： | 0 |
| 5 | The in vivo targeted molecular imaging of fluorescent silicon nanoparticles in Caenorhabditis elegans显示文摘 | Yanfeng Zhou Yun Zhang Yiling Zhong Rong Fu Sicong Wu Qin Wang Houyu Wang Yuanyuan Su Huimin Zhang Yao He | 2018 | Nano Research2018，11，5： | 0 |
| 6 | Bacterial community diversity of meltwater runoff and soil in Midre Lovénbreen glacier in Ny-Alesund,Arctic显示文摘Glacial meltwater runoff is a dynamic ecosystem.On the one hand,nutrient concentration changes as it flows from upstream to downstream,and on the other hand,bacterial community structure changes due to its contact with nearby soil during the flow process.We studied meltwater and soil in the Midre Lovénbreen glacier region,to explore changes in bacterial diversity as meltwater flows,and the relationship between meltwater and soil bacterial diversity.As glacial meltwater flows from upstream to downstream,the relative abundance of dominant bacterial groups changes.In addition,we found that during the flowing process,nutrient exchange and bacterial contact had occurred between the meltwater runoff and the soil.As a result,the distribution patterns of some bacteria in the meltwater are very similar to those in the soil.Finally,we combined distance-based redundancy analysis and weighted correlation network analysis to show that NO_(3)^(-)-N and NO_(2)^(-)-N are the most two significant factors affecting glacial meltwater and soil,respectively.Our results suggest that in such a close-knit ecosystem,the interaction of glacial meltwater with soil,as well as environmental factors,together determine bacterial community composition. | LIN Lidong WANG Nengfei HAN Wenbing ZHANG Botao ZANGJiaye LI Qinxin QIN Yiling WANG Long ZHANG Fang LIU Jie | 2022 | Advances in Polar Science2022，33，2： | 0 |
| 7 | Management and operation of extra-large Fangcang hospitals:experience and lessons from containing the highly contagious SARS-CoV-2 Omicron in Shanghai,China显示文摘Introduction Omicron is more contagious and stealthier than the previous strains.The basic reproduction number of Omicron is around 8–12,whereas that of the previous mainstream strain Delta is only 5–8[1].Omicron’s symptoms are relatively mild[2]compared with Delta’s symptoms;however,Omicron’s transmission ability is very strong,and its risk to children and the elderly remains high[3].In addition,the vaccine’s preventive effect on Omicron has weakened.Therefore,Omicron can easily cause a rapid outbreak in a city.The population density of megacities and the limited public health resources further exacerbate the difficulty of Omicron prevention and control. | Yun Xian Chenhao Yu Minjie Chen Lin Zhang Xinyi Zheng Shijian Li Erzhen Chen Zhongwan Chen Weihua Chen Chaoying Wang Qingrong Xu Tao Han Weidong Ye Wenyi Xu Xu Zhuang Yu Zheng Min Chen Jun Qin Yu Feng Shun Wei Yiling Fan Zhiruo Zhang Junhua Zheng | 2023 | Frontiers of Medicine2023，17，1： | 0 |
| 8 | Phytochemical activators of Nrf2:a review of therapeutic strategies in diabetes显示文摘Insulin resistance(IR)is fundamental to the development of type 2 diabetes(T2D),and altered mitochondrial function and abnormal lipid distribution are closely associated with IR or T2D.Excess oxidative stress-induced mitochondrial damage leads to an imbalance in redox homeostasis,which is considered the major contributor to the progression of diabetes.A key cellular defense mechanism,namely,the nuclear factor-E2 p45-related factor 2(Nrf2)-antioxidant response element(ARE)pathway,plays an essential protective role in combating excess oxidative stress.A series of phytochemicals are reported to improve IR and restore mitochondrial function against excess oxidative stress by activating the Nrf2-ARE signaling pathway to maintain cellular reactive oxygen species(ROS)homeostasis.The present review focuses on key knowledge gaps in the Nrf2-ARE system targeted by phytochemicals and its correlation to diabetes both in the in vitro and in vivo models and recent achievements in human clinical trials to evaluate its efficiency and safety.In addition,we provide an overview of recent research progress in nutrigenomics,precision nutrition and the interactions occurring in gut microbiota associated with the Nrf2-ARE signaling pathway and diabetes chemoprevention by phytochemicals and finally propose a future research strategy for regulating redox and microbiota balance via the Nrf2-ARE pathway.The present review aims to help us comprehensively understand the critical chemopreventive role of the Nrf2-ARE pathway targeted by phytochemicals in diabetes. | Si Qin Zhong Chen Yiling Wen Yuhang Yi Chenghao Lv Chaoxi Zeng Lanming Chen Meng Shi | 2023 | Acta Biochimica et Biophysica Sinica2023，55，1： | 0 |
| 9 | A cationic amphiphilic tetraphenylethylene derivative with hydrochromic sensitive property:Applications in anti-counterfeiting ink and rewritable paper显示文摘Since the discovery of aggregation induced emission(AIE)phenomenon,various stimuli-responsive materials have been rapidly developed,but there are still great challenges in the application of ink printing due to the bad water solubility.In this research,a new cationic amphiphilic TPE-functionalized pyridine salt(TPE-OTs)was designed,which shows good water solubility and hydrochromic properties.The optical properties of the compound have been studied,which is equipped with the typical AIEE characteristics and TICT effect.The compound can self-assemble to form aggregates with a particle size of about 30 nm in water.What is more,the compound is responsive to the environmental humidity,whose fluorescent color changes from green to yellow as the humidity gradually increased.Based on this characteristic,we applied it to the fluorescent anti-counterfeiting ink,realizing the protection and encryption of information. | Qian Xu Ziyu Qin Yiling Bei Shengyu Feng Xing-Dong Xu | 2022 | Chinese Chemical Letters2022，33，11： | 0 |
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