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| 1 | Unusual life-threatening Rosai-Dorfman disease of the trachea. role of NF-kappa B显示文摘 | Zhou, LF Chen, LA Zhu, QA Wang, C Xu, H Cui, XF Jiang, LF He, Ski Huang, M Yin, KS | 2010 | 南京医科大学学报(自然科学版)2010，30，11： | 21 |
| 2 | Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53显示文摘Our preliminary study shows that cinnamaldehyde(CA)could protect against intestinal ischemia/reperfusion(I/R)injuries,in which p53 and NF-κB p65 play a synergistic role.In this study,we conducted in vivo and in vitro experiments to verify this proposal.SD rats were pretreated with CA(10 or 40 mg·kg−1·d−1,ig)for 3 days,then subjected to 1 h mesenteric ischemia followed by 2 h reperfusion.CA pretreatment dose-dependently ameliorated morphological damage and reduced inflammation evidenced by decreased TNF-α,IL-1β,and IL-6 levels and MPO activity in I/R-treated intestinal tissues.CA pretreatment also attenuated oxidative stress through restoring SOD,GSH,LDH,and MDA levels in I/R-treated intestinal tissues.Furthermore,CA pretreatment significantly reduced the expression of inflammation/apoptosis-related NF-κB p65,IKKβ,IK-α,and NF-κB p50,and downregulated apoptotic protein expression including p53,Bax,caspase-9 and caspase-3,and restoring Bcl-2,in I/R-treated intestinal tissues.We pretreated IEC-6 cells in vitro with CA for 24 h,followed by 4 h hypoxia and 3 h reoxygenation(H/R)incubation.Pretreatment with CA(3.125,6.25,and 12.5μmol·L−1)significantly reversed H/R-induced reduction of IEC-6 cell viability.CA pretreatment significantly suppressed oxidative stress,NF-κB activation and apoptosis in H/R-treated IEC-6 cells.Moreover,CA pretreatment significantly reversed mitochondrial dysfunction in H/R-treated IEC-6 cells.CA pretreatment inhibited the nuclear translocation of p53 and NF-κB p65 in H/R-treated IEC-6 cells.Double knockdown or overexpression of p53 and NF-κB p65 caused a synergistic reduction or elevation of p53 compared with knockdown or overexpression of p53 or NF-κB p65 alone.In H/R-treated IEC-6 cells with double knockdown or overexpression of NF-κB p65 and p53,CA pretreatment caused neither further decrease nor increase of NF-κB p65 or p53 expression,suggesting that CA-induced synergistic inhibition on both NF-κB and p53 played a key role in ameliorating intestinal I/R injuries.Finally,we used immunoprecipitation assay to demonstrate an interaction between p53 and NF-κB p65,showing the basis for CA-induced synergistic inhibition.Our results provide valuable information for further studies. | Marwan Almoiliqy Jin Wen Bin Xu Yu-chao Sun Meng-qiao Lian Yan-li Li Eskandar Qaed Mahmoud Al-Azab Da-peng Chen Abdullah Shopit Li Wang Peng-yuan Sun Yuan Lin | 2020 | Acta Pharmacologica Sinica2020，41，9： | 5 |
| 3 | Apical tomography and modulation of ICAM-1 expression on activated endothelium显示文摘 | Almenar QA Duperray A Miles LA | 1995 | Am J Pathol1995，147，5： | 2 |
| 4 | Histological changes in the normal rat brain after gamma irradiation显示文摘 | Kassell NF Thai QA | 1996 | Acta Neurochir (Wien)1996，138，： | 1 |
| 5 | Anterior cervical plate fixation:A biomechanical study to evaluate the effects design,endplate preparation,and bone mineral density显示文摘 | Dvorak MF Pitzen T Zhu QA | 2005 | Spine2005，30，3： | 1 |
| 6 | Heart rate variability in early phase of acute myocardial infarction and convalescence 显示文摘 | Hussain S Siddique S Saboor QA | 2003 | J Coil Physicians Surg Pak2003，13，2： | 1 |
| 7 | The predictive validity of general movements--a systematic revicw显示文摘 | Burger M Louw QA | 2009 | Eur J Paediatr Neurol2009，13，5： | 1 |
| 8 | An unusual innervationof pectorlis and major muscles from a branch of the intercosbrachialnerve显示文摘 | Loukas M Louis RG Jr Fogg QA | 2006 | Clin Anat2006，19，04： | 1 |
| 9 | Serum amyloid A, properdin, complement 3, and toll-like receptors are expressed locally in human sinonasal tissue 显示文摘 | Lane AP Truong-Tran QA Myers A | 2006 | Am J Rhinol2006，20，1： | 1 |
| 10 | Community-aquired Pneumonia in elderly Patients显示文摘 | Niedemran MS Ahmed QA | 2003 | Clin Geriatr Med2003，19，1： | 1 |
| 11 | Applications of magnetic nanoparticles in biomedicine 显示文摘 | Pankhurst QA Connolly J Jones SK | 2003 | J Phys D: Appl Phys2003，36，13： | 1 |
| 12 | Abnormal ankle brachial index and the presence of significant coronary artery disease 显示文摘 | Hakeem F Siddique S Saboor QA | 2010 | J Coil Physicians Surg Pak2010，20，2： | 1 |
| 13 | Polyphenols from Ginkgo biloba 显示文摘 | Qa'dan F Nahrstedt A Schmidt M | 2010 | Sci Pharrn2010，78，： | 1 |
| 14 | 'Nano-catalyst' for DNA transformation 显示文摘 | Yuan L Wang HW Yu QA | 2011 | Journal of Materials Chemistry2011，21，17： | 1 |
| 15 | Inhibition of experimental vasospasm in rats with the periadventitial administration of ibuprofen using controlled - release polymers显示文摘 | Thai QA Oshiro EM Tamargo RJ | 1999 | Stroke1999，30，1： | 1 |
| 16 | The effectiveness of virtual reality on reducing pain and anxiety in burn injury pa- tients:a systematic review显示文摘 | Morris LD Louw QA Grimmer- Somers K | 2009 | Clin J Pain2009，25，9： | 1 |
| 17 | Rapid Loss of fentanyl citrate admixed with fluorouraeil in polyvinyl chloride containers 显示文摘 | Xu QA Trissel LA Martinez JF | 1997 | Ann Pharmcother1997，31，3： | 1 |
| 18 | Serum KL-6 and surfactant proteins A and D in pediatric interstitial lung disease 显示文摘 | Al Salmi QA Walter JN Colasurdo GN | 2005 | Chest2005，127，： | 1 |
| 19 | Ceneral movements as a predictive 1001 of the neurological outcome in very low and extremely low birth weight infants-a South African perspr-ctive显示文摘 | Burger M Frieg A Louw QA | 2011 | Early Hum Dev2011，87，4： | 1 |
| 20 | Characteristic of immobilized cephalosporin C acylase and its application in one-step enzymatic conversion of cephalosporin C to 7-aminocephalosporanic acid 显示文摘 | Zhu XW Luo H Chang YH Su HB Li QA Yu HM Shen ZY | 2011 | World J Microb Biotechnol2011，27，4： | 1 |
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