|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Value of multi-disciplinary input into laparoscopic management of rectal cancer-An observational study显示文摘AIM To assess the impact of multi-disciplinary teams(MDTs)management in optimising the outcome for rectal cancers.METHODS We undertook a retrospective review of a prospectively maintained database of patients with rectal cancers(defined as tumours≤15 cm from anal verge)discussed at our MDT between Jan 2008 and Jan 2011.The data was validated against the national database to ensure completeness of dataset.The clinical course and follow-up data was validated using the institution’s electronic patient records.The data was analysed in terms of frequencies and percentages.Significance of any differences were analysed usingχ2 test.A Kaplan-Meier analysis was performed for overall survival and disease free survival.RESULTS Following appropriate staging,one hundred and thirtythree patients were suitable for potentially curative resections.Seventy two(54%)were upper rectal cancer(URC)-tumour was>6 cm from the anal verge and 61(46%)were lower rectal cancers(LRC)-lower extent of the tumour was palpable≤6 cm.Circumferential resection margin(CRM)appeared threatened on preoperative MRI in 19/61(31%)patients with LRC requiring neo-adjuvant therapy(NAT).Of the 133 resections,118(89%)were attempted laparoscopically(5%conversion rate).CRM was positive in 9(6.7%)patients;Median lymph node harvest was 12(2-37).Major complications occurred in 8(6%)patients.Median follow-up was 53 mo(0-82).The 90-d mortality was 2(1.5%).Over the followup period,disease related mortality was 11(8.2%)and overall mortality was 39(29.3%).Four(3%)patients had local recurrence and 22(16.5%)patients had distant metastases.CONCLUSION Management of rectal cancers can be optimized with multidisciplinary input to attain acceptable long-term oncological outcomes even when incorporating a laparoscopic approach to rectal cancer resection. | Pawan Kumar Dhruva Rao Sooriyaratchige Pradeep Manjula Peiris Seema Safia Arif Rhodri A Davies Ashraf Gergies Masoud Puthucode Narayanan Haray | 2017 | World Journal of Gastrointestinal Surgery2017，9，6： | 2 |
| 2 | Comparison of pre - treatment CYFRA 21-1 and SCC - Antigenassay in primary cervical carcinoma - a preliminary report 显示文摘 | PUTHUCODE - EASWARAN S NAIK R ATHAVALE R | 2005 | JObstet Gynaecol2005，25，5： | 1 |
| 3 | Temporal and spatial expression of Hoxa-2 during murine palatogenesis显示文摘 | Nazarali A Puthucode R Leung V | 2000 | Cell Mol Neurobiol2000，20，3： | 1 |
| 4 | A conformational and structure-activity relationship study of cytotoxic 3,5-bis ( arylidene ) -4-piperidones and related N-acryloyl analogues显示文摘 | DIMMOCK J R PADMANILAYAM M P PUTHUCODE R N | 2001 | J Med Chem2001，44，4： | 1 |
| 5 | RNA Interference—A Silent but an Efficient Therapeutic Tool显示文摘 | Puthucode Venkatakrishnan Ramachandran Savarimuthu Ignacimuthu | 2013 | Applied Biochemistry and Biotechnology2013，，6： | 1 |
| 6 | A conformational and structure-activity relationship study of eytotoxie 3,5-bis(arylidene)-4-piperidones and related N-acryloyl analogues显示文摘 | Dimmock J R Padmanilayam M P Puthucode R N | 2001 | J Med Chem2001，44，： | 1 |
| 7 | Temporal and spatial expression of Hoxa-2during murine palatogenesis显示文摘 | Nazarali A Puthucode R Leung V | 2000 | Cell Mol Neurobiol2000，20，3： | 1 |
| 8 | A conformational and structure-activity relationship study of cytotoxic 3,5-bis(arylidene)-4-piperidones and related N-acryloyl analogues显示文摘 | Dimmock J R Padmanilayam M P Puthucode R N | 2001 | J Med Chem2001，44，4： | 1 |
| 9 | Feasibility and oncological outcomes of laparoscopic rectal resection following neo-adjuvant chemo-radiotherapy: A systematic review显示文摘AIM: To study the feasibility and oncological outcomesfollowing laparoscopic total mesorectal excision(LTME) in patients who have received Neo-adjuvant long course chemo-radiotherapy(LCRT). METHODS: A protocol driven systematic review of published literature was undertaken to assess the feasibility and oncological outcomes following LTME in patients receiving LCRT. The feasibility was assessed using peri-operative outcomes and short term results. The oncological outcomes were assessed using local recurrence, disease free survival and overall survival.RESULTS: Only 8 studies-1 randomized controlled trial, 4 Case Matched/Controlled Studies and 3 Case Series were identified matching the search criteria. The conversion rate was low(1.2% to 28.1%), anastomotic leak rates were similar to open total mesorectal excision(0%-4.1% vs 0%-8.3%). Only 3 studies reported on local recurrence rates(5.2%-7.6%) at median 34 mo follow-up. A single study described disease free survival and overall survival at 3 years as 78.8% and 92.1% respectively. CONCLUSION: LTME following LCRT is feasible in experienced hands, with acceptable short term surgical outcomes and with the usual benefits associated with minimally invasive procedures. The long term oncological outcomes of LTME after LCRT appear to be comparable to open procedures but need further investigation. | Pawan Kumar Dhruva Rao Manojkumar S Nair Puthucode N Haray | 2015 | World Journal of Surgical Procedures2015，5，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员