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| 1 | Trabectedin therapy as an emerging treatment strategy for recurrent platinum-sensitive ovarian cancer显示文摘Epithelial ovarian cancer(OC) is a common gynecologic malignancy in women. The standard treatment for OC is maximal cytoreductive surgical debulking followed by platinum-based chemotherapy. Despite the high response rate to primary therapy, approximately 85% of patients will develop recurrent ovarian cancer(ROC). This review identifies the clinical use of trabectedin in the treatment algorithm for ROC, with specific emphasis on platinum-sensitive ROC, for which trabectedin in combination with pegylated liposomal doxorubicin has been approved as a treatment protocol. The main mechanisms of action of trabectedin at the cellular level and in the tumor microenvironment is also discussed as bases for identifying biomarkers for selecting patients who may largely benefit from trabectedin-based therapies. | José Antonio López-Guerrero Ignacio Romero Andrés Poveda | 2015 | Chinese Journal of Cancer2015，34，1： | 5 |
| 2 | Study on the effect of landfill leachate on nutrient removal from municipal wastewater显示文摘In this study, landfill leachate with and without pre-treatment was co-treated with municipal wastewater at different mixing ratios. The leachate pre-treatment was achieved by air stripping to removal ammonia. The objective of this study was to investigate the effect of landfill leachate on nutrient removal of the wastewater treatment process. It was demonstrated that when landfill leachate was co-treated with municipal wastewater, the high ammonia concentration in the leachate did not have a negative impact on the nitrification. The system was able to adapt to the environment and was able to improve nitrification capacity. The readily biodegradable portion of chemical oxygen demand(COD)in the leachate was utilized by the system to improve phosphorus and nitrate removal.However, this portion was small and majority of the COD ended up in the effluent thereby decreased the quality of the effluent. The study showed that the 2.5% mixing ratio of leachate with wastewater improved the overall biological nutrient removal process of the system without compromising the COD removal efficiency. | Qiuyan Yuan Huijun Jia Mario Poveda | 2016 | Journal of Environmental Sciences2016，28，5： | 3 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Treatment of idiopathic membranous nephropathy with the combination of steroids,tacrolimus and mycophenolate mofetil:results of a pilot study显示文摘 | Ballarin J Poveda R Ara J | 2007 | Nephrol Dial Transplant2007，22，11： | 1 |
| 5 | Multimodality treatment in locore-gional gynecological cancer: cervical cancer treatment update显示文摘 | Poveda A Gonzalez-Martin A | 2008 | Ann Oncol2008，19，7： | 1 |
| 6 | Leucocytoclastic vasculitis associated with golimumab 显示文摘 | pAMIES A CASTRO S POVEDA MJ | 2013 | Rheumatology (Oxford)2013，52，10： | 1 |
| 7 | Economic development and growth in Colombia:an empirical analysis with super-efficiency DEA and panel data显示文摘 | Poveda A C | 2011 | Sociol-Economic Planning Sciences2011，45，4： | 1 |
| 8 | Analog Current-mode Implementation of a One-cycle Integrated Controller for Switching Power Converters显示文摘 | E Alarcon A Poveda | 2001 | IEEE Transactions on Power Electronics2001，，1： | 1 |
| 9 | Use of polymerase chain reaction for improved diagnosis of tuberculosis in children显示文摘 | Delacourt C Poveda J D Chureau C | | 0，，： | 1 |
| 10 | Serological identification of mycoplasmas by growth and metabolic inhibition tests 显示文摘 | Poveda J B Nicholas R | 1998 | Methods Mol Biol1998，104，： | 1 |
| 11 | Biochemical characteristics in mycoplasma identifica- tion显示文摘 | Poveda J B | 1998 | Methods Mol Biol1998，104，： | 1 |
| 12 | Rate effect on the mechanical properties of eight types of high strength concrete and comparison with FIB MC2010 显示文摘 | ZHANG X RUIZ G YU R C POVEDA E PORRAS R | 2012 | Construction and Building Materials2012，30，： | 1 |
| 13 | Anti-angiopoietin therapy with trebananib for recurrent ovarian cancer (TRINOVA-1): a randomised, multicentre, double-blind, placebo-controlled phase 3 trial 显示文摘 | Monk B J Poveda A Vergote I | 2014 | Lancet Oncol2014，15，8： | 1 |
| 14 | Landscape simplification decreases wild bee pollination services to strawberry显示文摘 | Connelly H Poveda K Loeb G | 2015 | Agriculture Ecosystems & Environment2015，211，： | 1 |
| 15 | Gemcitabine in patients with ovarian cancer显示文摘 | Poveda A | 2005 | Cancer Treat Rev2005，，4： | 1 |
| 16 | Economic development and growth in Colombia: an empirical analysis with super-efficiency DEA and panel data显示文摘 | Poveda A C | 2011 | Socio-Economie Planning Sciences2011，45，4： | 1 |
| 17 | Gemcitabine in patients with ovarian cancer 显示文摘 | Poveda A | 2005 | Cancer Treat Rev2005，，4： | 1 |
| 18 | Characterisati- on of 19 almond cuhivars on the basis of their free amino acids composition显示文摘 | Helena S L Poveda E G Moya M S P | 1998 | Food Chemistry1998，61，4： | 1 |
| 19 | A randomized phase II (RP2) trial of ridaforolimus (R) compared with progestin (P) or chemotherapy (C) in female adult patients with advanced endometrial carcinoma显示文摘 | Oza A M Poveda A Clamp AR | 2011 | J Clin Oncol2011，29，24： | 1 |
| 20 | Contribution of nitric oxide to exercise-induced changes in healthy volunteers:effects of acute exercise and long-term physical training显示文摘 | Poveda JJ Riestra A Salas E | 1997 | Eur J Clin Invest1997，27，11： | 1 |
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