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| 1 | Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review显示文摘Background:The coronavirus disease(COVID-19)has been identified as the cause of an outbreak of respiratory illness in Wuhan,Hubei Province,China beginning in December 2019.As of 31 January 2020,this epidemic had spread to 19 countries with 11791 confirmed cases,including 213 deaths.The World Health Organization has declared it a Public Health Emergency of International Concern.Methods:A scoping review was conducted following the methodological framework suggested by Arksey and O'Malley.In this scoping review,65 research articles published before 31 January 2020 were analyzed and discussed to better understand the epidemiology,causes,clinical diagnosis,prevention and control of this virus.The research domains,dates of publication,journal language,authors'affiliations,and methodological characteristics were included in the analysis.All the findings and statements in this review regarding the outbreak are based on published information as listed in the references.Results:Most of the publications were written using the English language(89.2%).The largest proportion of published articles were related to causes(38.5%)and a majority(67.7%)were published by Chinese scholars.Research articles initially focused on causes,but over time there was an increase of the articles related to prevention and control.Studies thus far have shown that the virus7 origination is in connection to a seafood market in Wuhan,but specific animal associations have not been confirmed.Reported symptoms include fever,cough,fatigue,pneumonia,headache,diarrhea,hemoptysis,and dyspnea.Preventive measures such as masks,hand hygiene practices,avoidance of public contact,case detection,contact tracing,and quarantines have been discussed as ways to reduce transmission.To date,no specific antiviral treatment has proven effective;hence,infected people primarily rely on symptomatic treatment and supportive care.Conclusions:There has been a rapid surge in research in response to the outbreak of COVID-19.During this early period,published research primarily explored the epidemiology,causes,clinical manifestation and diagnosis,as well as prevention and control of the novel coronavirus.Although these studies are relevant to control the current public emergency,more high-quality research is needed to provide valid and reliable ways to manage this kind of public health emergency in both the short-and long-term. | Sasmita Poudel Adhikari Sha Meng Yu-Ju Wu Yu-Ping Mao Rui-Xue Ye Qing-Zhi Wang Chang Sun Sean Sylvia Scott Rozelle Hein Raat Huan Zhou | 2020 | Infectious Diseases of Poverty2020，9，2： | 28 |
| 2 | DDR2 inhibition reduces migration and invasion of murine metastatic melanoma cells by suppressing MMP2/9 expression through ERK/NF-κB pathway显示文摘变形黑瘤是最致命、逃避的癌症之一。骨胶原我通过矩阵 metalloproteinase MMP 2 的生产在细胞外的矩阵支持肿瘤房间的迁居和侵略并且 9。Discoidin 领域受体 DDR 2 是在包括胸和前列腺癌症的几种癌症类型被含有的骨胶原受体。然而,在鼠科的黑瘤房间的迁居和侵略的 DDR2 的角色少些被学习。在现在的学习,我们响应骨胶原在 B16BL6 黑瘤房间的移植和侵略调查了效果和 DDR2 的内在的机制我。结果证明 DDR2 被表示并且是由骨胶原的 phosphorylated 我在房间。在用小介入的 RNA siRNA 途径的 DDR2 的下面规定之上,两个都,房间,迁移、侵略的显型显著地被稀释什么时候与控制房间相比。这效果在 DDR2 抑制之上经由 MMP2/9 的抑制被调停。而且,由特定的 siRNA 的 DDR2 的抑制显著地在房间减少了细胞外的调整 kinase 英皇家空军之阶级最低之兵 1 和 2 的激活和 kappa B NF-B 的原子因素什么时候与控制房间相比。总的来说,这些数据表明了 ERK1/2 和 NF-B 的那 DDR2 调停 siRNA 的抑制能下面调整响应骨胶原的 MMP2/9 的表情我减少房间的迁移、侵略的显型。 | Barun Poudel Young-Mi Lee Dae-Ki Kim | 2015 | Acta Biochimica et Biophysica Sinica2015，47，4： | 11 |
| 3 | Serum uric acid level in newly diagnosed essential hypertension in a Nepalese population:A hospital based cross sectional study显示文摘Objective:To develop the missing link between hyperuricemia and hypertension.Methods:The study was conducted in Department of Biochemistry in collaboration with Nephrology Unit of Internal Medicine Department.Hypertension was defined according to blood pressure readings by definitions of the Seventh Report of the Joint National Committee.Totally 205newly diagnosed and untreated essential hypertensive cases and age-sex matched nonnotensive controls were enrolled in the study.The potential confounding factors of hyperuricemia and hypertension in both cases and controls were controlled.Uric acid levels in all participants were analyzed.Results:Renal function between newly diagnosed hypertensive cases and nonnotensive healthy controls were adjusted.The mean serum uric acid observed in newly diagnosed hypertensive cases and in nonnotensive healthy controls were(290.05±87.03)μmol/L and(245.24±09.38)μmol/L respectively.A total of 59(28.8%)participants of cases and 28(13.7%)participants of controls had hyperuricemia(odds ratio 2.555(95%CI:1.549-4.213),P<0.00l).Conclusions:The mean serum uric acid leveb and number of hyperuricemic subjects were found to be significantly higher in cases when compared to controls. | Bibek Poudel Binod Kumar Yadav Arun Kumar Bharat Jha Kanak Bahadur Raut | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，1： | 10 |
| 4 | TiO2 coated urchin-like SnO2 microspheres for efficient dye-sensitized solar cells显示文摘 | Amit Thapa Jiantao Zai Hytham Elbohy Prashant Poudel Nirmal Adhikari Xuefeng Qian Qiquan Qiao | 2014 | Nano Research2014，7，8： | 7 |
| 5 | High universality of matK primers for barcoding gymnosperms显示文摘DNA barcoding is a tool to provide rapid and accurate taxonomic identification using a standard DNA region.A two-marker combination of matK+rbcL was formally proposed as the core barcode for land plants by the Consortium for the Barcode of Life Plant Working Group.However,there are currently no barcoding primers for matK showing high universality in gymnosperms.We used 57 gymnosperm species representing 40 genera,11 families and four subclasses to evaluate the universality of nine candidate matK primers and one rbcL primer in this study.Primer(1F/724R) of rbcL is proposed here as a universal primer for gymnosperms due to high universality.One of the nine candidate matK primers(Gym_F1A/Gym_R1A) is proposed as the best 'universal' matK primer for gymnosperms because of high polymerase chain reaction success and routine generation of high quality bidirectional sequences.A specific matK primer for Ephedra was newly designed in this study,which performed well on the sampled species.The primers proposed here for rbcL and matK can be easily and successfully amplified for most gymnosperms. | Yan LI Lian-Ming GAO Ram C. POUDEL De-Zhu Li Alan FORREST | 2011 | Journal of Systematics and Evolution2011，49，3： | 5 |
| 6 | 局限期小细胞肺癌化疗联合加速超分割放疗疗效初步分析显示文摘背景与目的:局限期小细胞肺癌(small cell lung cancer,SCLC)对放疗和化疗均敏感。放疗可提高局限期SCLC患者总生存率,降低局部复发率。本研究总结在化疗基础上应用加速超分割放射治疗(hyperfractionated accelerated radiotherapy,HART)对局限期SCLC的疗效,评价相关治疗毒性,归纳治疗失败方式。方法:55例局限期SCLC患者经过EP方案诱导化疗,放疗后再以EP方案巩固化疗,完全缓解(complete remission,CR)者行预防性全脑照射(prophylactic cranial irradiation,PCI)。治疗结束后对患者进行随访,并评价其疗效及毒副作用。结果:55例患者放化疗结束时总有效率(CR+PR)为87.3%。1、3、5年总生存率分别为79.1%、40.3%、16.1%,中位生存时间18.7个月。Ⅲ度和Ⅳ度血液学毒性分别为23例(41.8%)和16例(29.1%);Ⅰ度和Ⅱ度急性放射性肺炎分别为21例(38.2%)和2例(3.6%),Ⅰ度和Ⅱ度放射性食管炎分别为29例(52.7%)和12例(21.8%),未发生Ⅲ~Ⅳ度非血液学毒性。11例(20.0%)患者出现Ⅰ度肺纤维化,5例(9.1%)为Ⅱ度。2例(3.6%)发生Ⅰ度后期食管损伤。16例(29.1%)局部/区域复发,21例(38.2%)发生远处转移。结论:EP方案化疗合并HART治疗局限期SCLC毒性轻至中度,患者可以耐受。局部复发和远处转移为主要治疗失败原因。 | 胡晓 包勇 陈媛媛 高剑铭 王卫华 刘源 何瀚 孙宗文 Shivaji Poudel 王彦 庄婷婷 张力 陈明 | 2008 | 癌症2008，27，10： | 4 |
| 7 | ^137Cs tracing dynamics of soil erosion,organic carbon,and total nitrogen in terraced fields and forestland in the Middle Mountains of Nepal显示文摘The Middle Mountains is one of the regions of Nepal most vulnerable to water erosion, where fragile geology, steep topography, anomalous climatic conditions, and intensive human activity have resulted in serious soil erosion and enhanced land degradation. Based on the 137 Cs tracing method, spatial variations in soil erosion, organic carbon, and total nitrogen(TN) in terraced fields lacking field banks and forestland were determined. Soil samples were collected at approximately 5 m and 20 m intervals along terraced field series and forestland transects respectively. Mean 137 Cs inventories of the four soil cores from the reference site was estimated at 574.33 ± 126.22 Bq m-2(1 Bq(i.e., one Becquerel) is equal to 1 disintegration per second(1 dps)). For each terrace, the 137 Cs inventory generally increased fromupper to lower slope positions, accompanied by a decrease in the soil erosion rate. Along the entire terraced toposequence, 137 Cs data showed that abrupt changes in soil erosion rates could occur between the lower part of the upper terrace and the upper part of the immediate terrace within a small distance. This result indicated that tillage erosion is also a dominant erosion type in the sloping farmland of this area. At the same time, we observed a fluctuant decrease in soil erosion rates for the whole terraced toposequence as well as a net deposition at the toe terrace. Although steep terraces(lacking banks and hedgerows) to some extent could act to limit soil sediment accumulation in catchments, soil erosion in the terraced field was determined to be serious. For forestland, with the exception of serious soil erosion that had taken place at the top of slopes due to concentrated flows from a country road situated above the forestland site, spatialvariation in soil erosion was similar to the 'standard' water erosion model. Soil organic carbon(SOC) and TN inventories showed similar spatial patterns to the 137 Cs inventory for both toposequences investigated. However, due to the different dominant erosion processes between the two, we found similar patterns between the <0.002 mm soil particle size fraction(clay sized) and 137 Cs inventories in terraced fields, while different patterns could be found between 137 Cs inventories and the <0.002 mm soil particle size fraction in the forestland site. Such results confirm that 137 Cs can successfully trace soil erosion, SOC and soil nitrogen dynamics in steep terraced fields and forestland in the Middle Mountains of Nepal. | SU Zheng-an XIONG Dong-hong DENG Wei DONG Yi-fan MA Jing PADMA C Poudel GURUNG B Sher | 2016 | Journal of Mountain Science2016，13，10： | 4 |
| 8 | 石榴SUT基因家族鉴定及其在籽粒发育过程中的表达分析显示文摘【目的】对石榴SUT家族基因成员进行全基因组鉴定,并分析SUT家族基因成员的结构域特征、启动子序列、生化特征、进化关系和表达特性,为深入研究该基因作用及其分子调控机制提供参考。【方法】利用同源比对及HMMER模型鉴定石榴SUT基因家族成员;利用邻近法和基因结构分析解析石榴SUT基因及其启动子序列的系统发生关系。【结果】共鉴定了10个石榴SUT基因,可以分为3大类;石榴SUT基因及其启动子区的GC含量都明显低于其在拟南芥和水稻中的含量;石榴SUT家族基因GC含量远高于启动子区的GC含量;石榴SUT基因的序列长度与GC含量呈明显正相关;石榴SUT基因启动子区含有10种MYB元件;此外,4个石榴SUT基因(PgL0328370.1、PgL0099690.1、PgL0145810.1和PgL0145770.1)在籽粒发育过程中发生了差异表达。【结论】SUT基因在进化过程中其序列和基因结构相对保守,而其启动子序列在进化过程中变化较大,SUT基因的表达量变化与籽粒发育显著相关。 | 骆翔 曹尚银 李好先 赵弟广 张富红 陈丽娜 Krishna Poudel 敬丹 唐丽颖 | 2020 | 果树学报2020，37，4： | 3 |
| 9 | Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies显示文摘Misfoldedα-synudein is a major component of Lewy bodies,which are a hallmark of Parkinson's disease(PD).A large body of evidence shows thatα-synuclein can aggregate into amyloid fibrils,but the relationship between a-synuclein self-assembly and Lewy body formation remains unclear.Here,we show,both in vitro and in a Caenorhabditis elegans model of PD,thatα-synuclein undergoes liquid-liquid phase separation by forming a liquid droplet state,which converts into an amyloid-rich hydrogel with Lewy-body-like properties.This maturation process towards the amyloid state is delayed in the presence of model synaptic vesicles in vitro.Taken together,these results suggest that the formation of Lewy bodies may be linked to the arrested maturation ofα-synuclein condensates in the presence of lipids and other cellular components. | Maarten C.Hardenberg Tessa Sinnige Sam Casford Samuel T.Dada Chetan Poudel Elizabeth A.Robinson Monika Fuxreiter Clemens F.Kaminksi Gabriele S.Kaminski Schierle Ellen A.A.Nollen Christopher M.Dobson Michele Vendruscolo | 2021 | Journal of Molecular Cell Biology2021，13，4： | 3 |
| 10 | Evaluation of sampling strategies to estimate crown biomass显示文摘Background:Depending on tree and site characteristics crown biomass accounts for a significant portion of the total aboveground biomass in the tree.Crown biomass estimation is useful for different purposes including evaluating the economic feasibility of crown utilization for energy production or forest products,fuel load assessments and fire management strategies,and wildfire modeling.However,crown biomass is difficult to predict because of the variability within and among species and sites.Thus the allometric equations used for predicting crown biomass should be based on data collected with precise and unbiased sampling strategies.In this study,we evaluate the performance different sampling strategies to estimate crown biomass and to evaluate the effect of sample size in estimating crown biomass.Methods:Using data collected from 20 destructively sampled trees,we evaluated 11 different sampling strategies using six evaluation statistics:bias,relative bias,root mean square error(RMSE),relative RMSE,amount of biomass sampled,and relative biomass sampled.We also evaluated the performance of the selected sampling strategies when different numbers of branches(3,6,9,and 12)are selected from each tree.Tree specific log linear model with branch diameter and branch length as covariates was used to obtain individual branch biomass.Results:Compared to all other methods stratified sampling with probability proportional to size estimation technique produced better results when three or six branches per tree were sampled.However,the systematic sampling with ratio estimation technique was the best when at least nine branches per tree were sampled.Under the stratified sampling strategy,selecting unequal number of branches per stratum produced approximately similar results to simple random sampling,but it further decreased RMSE when information on branch diameter is used in the design and estimation phases.Conclusions:Use of auxiliary information in design or estimation phase reduces the RMSE produced by a sampling strategy.However,this is attained by having to sample larger amount of biomass.Based on our finding we would recommend sampling nine branches per tree to be reasonably efficient and limit the amount of fieldwork. | Krishna P Poudel Hailemariam Temesgen Andrew N Gray | 2015 | Forest Ecosystems2015，2，1： | 2 |
| 11 | High-thermoelectric pergormance of nanostructured bismuth antimony telluride bulk alloys显示文摘 | POUDEL B HAO QING MA YI | 2008 | Science2008，320，5812： | 1 |
| 12 | Development of an in- house Loop-mediated isothermal amplification (lamp) assay for detection of mycobacterium tuberculosis and evaluation in spu- tum samples of patients 显示文摘 | Pandey BD Poudel A Yoda T | 2008 | J Med Microbiol2008，57，4： | 1 |
| 13 | Structural damage detection using digital video imaging technique and wavelet transformation显示文摘 | Poudel U P Fu G Ye J | 2005 | Journal of Sound and Vibration2005，286，45： | 1 |
| 14 | Effect of red-and blue- light-emitting diodes on growth and morphogenesis of grapes显示文摘 | Poudel P R Kataoka I Mochioka R | 2008 | Plant cell tissue and organ culture2008，92，2： | 1 |
| 15 | Development of an in - houseloop - mediated isothermal amplification ( LAMP) assay for detectionof Mycobacterium tuberculosis and evaluation in sputum samples ofNepalese patients显示文摘 | Pandey BD Poudel A Yoda T | 2008 | J Med Microbiol2008，57，4： | 1 |
| 16 | Sulfuretin induced miR- 30C selectively downregulates cyelin D1 and D2 and trig- gers cell death in human cancer cell lines 显示文摘 | Poudel S Song J Jin EJ | 2013 | Biochem Biophys Res Com-mun2013，，3： | 1 |
| 17 | High-thermoelectric performance of nanostructured bismuth antimony telluride balk alloys显示文摘 | Poudel B Hao Q Ma Y | 2008 | Science2008，320，5876： | 1 |
| 18 | 查看详情显示文摘 | Poudel B Hao Q Ma Y | | 0，，： | 1 |
| 19 | High-accuracy edge detection with blurred edge model显示文摘 | Ye J Fu G Poudel U P | 2005 | Image and Vision Computing2005，23，： | 1 |
| 20 | Effect of red- and blue-light-emitting diodes on growth and morphogenesis of grapes显示文摘 | Puspa Raj Poudel Ikuo Kataoka Ryosuke Mochioka | 2008 | Plant Cell Tiss Organ Cult2008，92，： | 1 |
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