|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Metastatic pattern in esophageal and gastric cancer:Influenced by site and histology显示文摘BACKGROUND Detailed information on metastatic patterns in of patients with esophageal and gastric cancer is limited.Early recognition of metastases is important to avoid futile locoregional treatments.Furthermore,knowledge on metastatic patterns is necessary for further development of personalized treatment modalities.AIM To gain insight into the metastatic pattern of gastroesophageal cancer.METHODS A nationwide retrospective autopsy study of 3876 patients with adenocarcinoma(AC)or squamous cell carcinoma(SCC)of the esophagus or stomach between 1990 and 2017 was performed.Only patient with metastases were included for analysis.The metastatic pattern was analyzed according to the primary tumor location and histological subtype.RESULTS Metastatic disease was found in 268 esophageal and 331 gastric cancer patients.In esophageal cancer,the most common metastatic locations were liver(56%),distant lymph nodes(53%)and lung(50%).Esophageal AC showed more frequently metastases to the peritoneum and bone compared with esophageal SCC.In gastric cancer,the most common metastatic locations were distant lymph nodes(56%),liver(53%)and peritoneum(51%).Intestinal-type AC of the stomach showed metastases to the liver more frequently,whereas metastases to the bone,female reproductive organs and colorectum were observed more frequently in diffuse-type gastric AC.CONCLUSION This study showed differences in metastatic patterns of patients with esophageal and gastric cancer according to the primary tumor location and histological subtype. | Moniek HP Verstegen Mitchell Harker Carlijn van de Water Jolanda van Dieren Niek Hugen Iris D Nagtegaal Camiel Rosman Rachel S van der Post | 2020 | World Journal of Gastroenterology2020，26，39： | 9 |
| 3 | Alternatives for large-scale production of cultured beef: A review显示文摘Cultured beef is a method where stem cells from skeletal muscle of cows are cultured in vitro to gain edible muscle tissue. For large-scale production of cultured beef, the culture technique needs to become more efficient than today's 2-dimensional(2D) standard technique that was used to make the first cultured hamburger. Options for efficient large-scale production of stem cells are to culture cells on microcarriers, either in suspension or in a packed bed bioreactor, or to culture aggregated cells in suspension. We discuss the pros and cons of these systems as well as the possibilities to use the systems for tissue culture. Either of the production systems needs to be optimized to achieve an efficient production of cultured beef. It is anticipated that the optimization of large-scale cell culture as performed for other stem cells can be translated into successful protocols for bovine satellite cells resulting in resource and cost efficient cultured beef. | Matilda S M Moritz Sanne E L Verbruggen Mark J Post | 2015 | Journal of Integrative Agriculture2015，14，2： | 7 |
| 4 | Application of auction as a price mechanism for the interchange of electric power显示文摘 | Post D L Coppinger S S Sheble G B | 1995 | IEEE Transactions on Power System1995，10，3： | 2 |
| 5 | A survey of perioperative therapy for elective colon resection in Germany, 2006显示文摘 | Hasenberg T Rittler P Post S | 2007 | Der Chirurg2007，78，9： | 1 |
| 6 | Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer:a randomized controlled trlal显示文摘 | Oettle H Post S Neuhaus P | 2007 | JAMA2007，297，3： | 1 |
| 7 | Application of auction as a pricing mechanism for the interchange of electric power 显示文摘 | Post D L Coppinger S S Sheble G B | 1995 | 1EEE Transactions on Power Systems1995，10，3： | 1 |
| 8 | A search of the missing carbon sink:a model of terrestrial biospheric response to landuse change and atmospheric CO2显示文摘 | King A W Emanuel W R Wullschleger S D and Post W M | 1995 | Tellus1995，47，： | 1 |
| 9 | Randomized clinical trial of lightweight composite mesh for Lichtenstein inguinal hernia repair显示文摘 | Post S | 2004 | Brit J Surg2004，91，1： | 1 |
| 10 | Balance between angiopoetin-1 and angiopoetin-2 is in favour of angiopoetin-2 in atherosclerotic plaques with high microvessel density 显示文摘 | Post S Peeters W Busser E | 2008 | J Vasc Res2008，45，3： | 1 |
| 11 | Formation of 2-Acetyl-l-pyrroline by Several Bacillus cereus Strains Isolated from Cocoa Fer- mentation Boxes显示文摘 | Romanczyk L J McClelland C A Post L S | 1995 | Journal of agricultural and food chemistry1995，43，2： | 1 |
| 12 | Electron beam CT versus helical CT scans for assessing coronary calcification: Current utility and future directions显示文摘 | NASIR K BUDOFF M J POST W S | 2003 | Am Heart J2003，146，6： | 1 |
| 13 | Emergent properties of neural systems:how focal molecular neurobiological alterations can affect behavior显示文摘 | POST R WEISS S R | 1997 | Developmental Psychopathology1997，，9： | 1 |
| 14 | Therapeutic angiogenesis using endocardial approach to administration: techniques and results 显示文摘 | Garcia L Bairn D S Post M | 1999 | Curt Interv Cardiol Rep1999，1，3： | 1 |
| 15 | Randomized clinical trial oflightweight composite mesh for Lichtenstein inguinal hernia repair 显示文摘 | Post S Weiss B Wilier M | 2004 | Br J Surg2004，91，1： | 1 |
| 16 | MRI of acute epidnral hematomas显示文摘 | Sklar EM Post JM Falcone S | 1999 | J Comput Assist Tomogr1999，23，： | 1 |
| 17 | Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial显示文摘 | Oettle H Post S Neuhaus P | 2007 | JAMA2007，297，3： | 1 |
| 18 | Recurrence risk of a de-livery before 34 weeks of pregnancy due to an early onset hyperten-sive disorder: a systematic review 显示文摘 | Langenveld J Jansen S van der Post J | 2010 | Am J Perinatol2010，27，7： | 1 |
| 19 | Against the principle surgical indications in inguinal hernia显示文摘 | Post S | 1997 | Chirurg1997，68，12： | 1 |
| 20 | Evaluation of disease status with sensitive measures of growth hormone secretion in 60 postoperative patients with acromegaly显示文摘 | Freda P U Post K D Powell J S | 1998 | J Clin Endocrin of Metabo1998，83，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员