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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Regulation of epithelium-specific Ets-like factors ESE-1 and ESE-3 in airway epithelial cells: potential roles in airway inflammation显示文摘航线发炎是许多呼吸障碍的特点,例如气喘和膀胱的纤维变性。在发炎触发的航线基因表示的变化在这些疾病的致病起一个关键作用。基因连接研究建议 ESE-2 和 ESE-3,编码上皮特定的 Ets-domain-containing 抄写因素,是候选人气喘危险性基因。我们这里报导 et 家庭抄写因素 ESE-1 的另一个成员的表示,以及 ESE-3,起来在支气管的上皮的房间线由煽动性的 cytokines interleukin-1beta (IL-1beta ) 和肿瘤坏死 factor-alpha (TNF-alpha ) 调整了。有 IL-1beta 和 TNF-alpha 的这些房间的处理为 ESE-1 和 ESE-3 导致了信使 rna 表示的戏剧的增加。我们证明导致的表示被抄写因素 NF-kappaB 的激活调停。我们描绘了 ESE-1 和 ESE-3 倡导者并且识别了为导致 cytokine 的表达式被要求的 NF-kappaB 有约束力的序列。另外,我们也表明那 ESE-1 在上面调整 ESE-3 表示, down 由 cytokines 调整它的自己的正式就职。最后,我们在 Elf3 显示出那(对人的 ESE-1 相应) 猛烈老鼠,煽动性的 cytokine interleukin-6 (IL-6 ) 的表示是调整的 down。我们的调查结果建议 ESE-1 和 ESE-3 在航线发炎起一个重要作用。 | Jing Wu Rongqi Duan Huibi Cao Deborah Field Catherine M Newnham David R Koehler Noe Zamel Melanie A Pritchard Paul Hertzog Martin Post A Keith Tanswell Jim Hu | 2008 | Cell Research2008，18，6： | 6 |
| 3 | The Machine Recognition for Population Feature of Wheat Images Based on BP Neural Network显示文摘Recognition and analysis of dynamic information about population images during wheat growth periods can be taken for the base of quantitative diagnosis for wheat growth. A recognition system based on self-learning BP neural network for feature data of wheat population images, such as total green areas and leaves areas was designed in this paper. In addition, some techniques to create favorable conditions for image recognition was discussed, which were as follows: (1) The method of collecting images by a digital camera and assistant equipment under natural conditions in fields. (2) An algorithm of pixei labeling was used to segment image and extract feature. (3)A high pass filter based on Laplacian was used to strengthen image information. The results showed that the ANN system was availability for image recognition of wheat population feature. | LI Shao-kun, SUO Xing-mei, BAI Zhong-ying, QI Zhi-li, Liu Xiao-hong, GAO Shi-ju and ZHAO Shuang-ning( Institute of Crop Breeding and Cultivation /Key Laboratory of Crop Genetic & Breeding, Ministry of Agriculture, ChineseAcademy of Agricultural Sciences, Beijing 100081 , P . R . China Department of Computer Science and Technology, CentralUniversity for Nationalities, Beijing 100081 , P. R . China School of Computer Science and Technology, Beijing Universityof Posts and Telecommunications, Beijing 100876, P. R . China Research Center of Xinjiang Crop High-yield,Shihezi University, Shihezi 832003, P.R. China) | 2002 | Agricultural Sciences in China2002，1，8： | 4 |
| 4 | Soil carbon pools and world life zones显示文摘 | POST W M EMANUEL W R ZINKE P J | 1982 | Nature1982，298，： | 1 |
| 5 | The global carbon cycle 显示文摘 | PENG T-H EMANUEL W R | 1990 | Am Sci1990，78，： | 1 |
| 6 | A search of the missing carbon sink:a model of terrestrial biospheric response to landuse change and atmospheric CO2显示文摘 | King A W Emanuel W R Wullschleger S D and Post W M | 1995 | Tellus1995，47，： | 1 |
| 7 | Soil carbon pools and world life zones显示文摘 | Post W M Emanuel W R Zinke P | 1982 | Nature1982，298，8： | 1 |
| 8 | Molecular analysis of bacterial pathogens in otitis media with effusion显示文摘 | POST J C PRESTON R A JEROME J A | 1995 | JAMA1995，273，： | 1 |
| 9 | Spectral Response of Plant Canopy with Different Soil Background显示文摘 | Huete A R Jackson R D Post D E | 1985 | Remote Sensing of Environment1985，17，1： | 1 |
| 10 | Emergent properties of neural systems:how focal molecular neurobiological alterations can affect behavior显示文摘 | POST R WEISS S R | 1997 | Developmental Psychopathology1997，，9： | 1 |
| 11 | Montoring and verifying changes of organic carbon in vsoil显示文摘 | Post W M Izaurralde R C Mann L K | 2001 | ClimaticChange2001，51，： | 1 |
| 12 | Soil carbon pools and world life zones显示文摘 | Post W M Rmanuel W R Zinke P J | 1982 | Nature1982，298，： | 1 |
| 13 | Immune cell function testing: an adjunct to therapeutic drug monito- ring in transplant patient management显示文摘 | Kowalski R Post D Schneider MC | 2003 | Clin Trans- plant2003，17，2： | 1 |
| 14 | Soil carbon pool and world life zone显示文摘 | Post W M Emanuel W R Zinke P J | 1982 | Nature1982，298，： | 1 |
| 15 | Projecting future concentrations of atmospheric CO2 with global carbon cycle models:the importance of simulating historical changes显示文摘 | King A W Emanuel W R Post W M | 1992 | Environment management1992，16，： | 1 |
| 16 | Long term tolera bility of the first wireless implant for electrical epiretinal stimulation 显示文摘 | Keserue M Post N Hornig R | 2009 | ARVO Meeting Abstracts2009，50，： | 1 |
| 17 | Long term tol-erability of the first wireless implant for electricalepiretinal stimulation 显示文摘 | Keserue M Post N Hornig R | 2009 | ARVO Meeting Abstracts2009，50，： | 1 |
| 18 | The global carbon cycle显示文摘 | Post W M Peng T H Emanuel W R | 1990 | American Scientist1990，78，： | 1 |
| 19 | Soil pool and world life zones 显示文摘 | Post W M Emanuel W R Zinke P J | 1982 | Nature1982，298，： | 1 |
| 20 | Soil carbon pools and world life zones 显示文摘 | POST W M EMANUEL W R | 1982 | Nature1982，298，： | 1 |
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