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| 1 | 慢性肾脏病中的炎症和动脉硬化:慢性肾功能不全队列研究中的发现显示文摘慢性肾脏病(chronic kidney disease,CKD)和动脉硬化程度与心血管病发病率和死亡率增加相关。目前认为炎症在动脉硬化发展中发挥作用,而CKD被认为是一种促炎症反应的状态。CKD患者的动脉僵硬度增加,横断面数据提示CKD中增多的炎症标志物与较高动脉僵硬度值相关。 | Peyster E Chen J Feldman HI Go AS Gupta J Mitra N Pan Q Porter A Rahman M Raj D Reilly M Wing MR Yang W Townsend RR 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，11： | 12 |
| 2 | Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4显示文摘AIM:To investigate the effect of Tenascin C(TNC)on the expression of pro-inflammatory cytokines and matrixmetalloproteinases in human cardiac myofibroblasts(CMF).METHODS:CMF were isolated and cultured from patients undergoing coronary artery bypass grafting.Cultured cells were treated with either TNC(0.1μmol/L,24 h)or a recombinant protein corresponding to different domains of the TNC protein;fibrinogen-like globe(FBG)and fibronectin typeⅢ-like repeats(TNⅢ5-7)(both 1μmol/L,24 h).The expression of the proinflammatory cytokines;interleukin(IL)-6,IL-1β,TNFαand the matrix metalloproteinases;MMPs(MMP1,2,3,9,10,MT1-MMP)was assessed using real time RT-PCR and western blot analysis.RESULTS:TNC increased both IL-6 and MMP3(P<0.01)mR NA levels in cultured human CMF but had no significant effect on the other markers studied.The increase in IL-6 mR NA expression was mirrored by an increase in protein secretion as assessed by enzymelinked immunosorbant assay(P<0.01).Treating CMF with the recombinant protein FBG increased IL-6mR NA and protein(P<0.01)whereas the recombinant protein TNⅢ5-7 had no effect.Neither FBG nor TNⅢ5-7 had any significant effect on MMP3 expression.The expression of toll-like receptor 4(TLR4)in human CMF was confirmed by real time RT-PCR,western blot and immunohistochemistry.Pre-incubation of cells with TLR4neutralising antisera attenuated the effect of both TNC and FBG on IL-6 mR NA and protein expression.CONCLUSION:TNC up-regulates IL-6 expression in human CMF,an effect mediated through the FBG domain of TNC and via the TLR4 receptor. | Azhar Maqbool Emma J Spary Iain W Manfield Michaela Ruhmann Lorena Zuliani-Alvarez Filomena O Gamboa-Esteves Karen E Porter Mark J Drinkhill Kim S Midwood Neil A Turner | 2016 | World Journal of Cardiology2016，8，5： | 4 |
| 3 | 洪水风险管理新方法在中国的应用显示文摘1引言
在亚洲开发银行的资助下,2006年初,澳大利亚GHD咨询公司和中国水利水电科学研究院合作完成了"中国洪水管理战略"研究。该研究的一个重要标志是构建了风险管理框架,将洪水风险定义为危险性(hazard,指洪水致灾的自然特性)、 | John W Porter 梁志勇 | 2010 | 中国防汛抗旱2010，20，3： | 3 |
| 4 | Effects of hoisting on the input shaping control of gantry cranes 显示文摘 | Singhose W Porter L Kenison M | 2000 | Control Engineering Practice2000，8，10： | 2 |
| 5 | Partition equilibriums of nonionic organic compounds between soil organic matter and water显示文摘 | Chiou C T Porter P E Schmedding D W | 1983 | Environ Sci Technol1983，17，： | 1 |
| 6 | Enhancing intestinal drug solubilisation using lipid-based delivery systems 显示文摘 | PORTER C J H POUTON C W CUINE J F | 2008 | Adv Drug Deliver Rev2008，60，6： | 1 |
| 7 | Therapeutic applications of lipid-coated microbubbles显示文摘 | UNGER E C PORTER T CULP W | 2004 | Adv Drug Deliv Rev2004，56，9： | 1 |
| 8 | Mass spectrometric study of gaseous species in the B-B2O3 system显示文摘 | INGHRAM M G PORTER R F CAHUPK W A | 1956 | Journal of Chemical Physics1956，25，3： | 1 |
| 9 | Sorption kinetic analysis for the removal of cadmium ions from effluents using bone char显示文摘 | CHEUNG C W PORTER J F MCKAY G | 2001 | Water Research2001，35，3： | 1 |
| 10 | Controlling growth of common carpet grass using selected plant growth regulators显示文摘 | Bush E W Porter W C | 1998 | Hortscience1998，33，4： | 1 |
| 11 | Effects of hoisting on the input shaping control of gantry cranes显示文摘 | Singhose W Porter L Kenison M | 2000 | Control Engineering Practice2000，8，6： | 1 |
| 12 | Exploring the relationships between design measures and software quality in object oriented systems 显示文摘 | Briand L C Wust J Daly J W Porter D V | 2000 | Journal of Systems and Software2000，51，3： | 1 |
| 13 | The effects of conflict, trust and task commitment on project team performance显示文摘 | PORTER T W LILLY B S | 1996 | The InternationalJournal of Conflict Management1996，7，： | 1 |
| 14 | Organizational commitment,job satisfaction,and turnover among psychiatric technicians显示文摘 | Porter L W Steers R M Mowday R T | | 0，，05： | 1 |
| 15 | Alternative approaches to the employee-organization rela- tionship:does investment in employees pay off显示文摘 | TSUI A S PEARCE J L PORTER L W TRIPOLI A M | 1997 | The A cademy of Management Journal1997，40，5： | 1 |
| 16 | Organization Commitment,Job Satisfaction and Turnover among Psychiatric Technicians显示文摘 | PORTER L W STEERS R M MOWDAY R T | 1974 | Journal of Applied Psychology1974，59，3： | 1 |
| 17 | Sorption kinetics for the removal of copper and zinc from effluents using bone char显示文摘 | Cheung C W Porter J F McKay G | 2000 | Separation and Purification Technology2000，19，1： | 1 |
| 18 | Correlations between polyamine analogue-induced increase in spermidine/spermine N1-aeetyltransferase activity,polyamine pool depletion,and growth inhibition in human melanoma cell lines显示文摘 | GANIS B LIBBY P R | 1991 | Cancer Res1991，51，： | 1 |
| 19 | The effects of conflict,trust and taskcommitment on Project team Performance显示文摘 | Porter T W Lilly B S | 1996 | The Interna-tional Journal of Conflict Management1996，7，： | 1 |
| 20 | Technology opportunities analysis:integrating technology monitoring, forecasting and assessment with strategic planning显示文摘 | Porter A L Jin X-Y Gilmour J E Cunningham S W Xu H Stanard C WangL | 1994 | SRA Journal (Society of Research Administrators)1994，，2： | 1 |
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