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| 1 | Influence of Genista Tinctoria L or Methylparaben on Subchronic Toxicity of Bisphenol A in Rats显示文摘Objective To evaluate the influence of an extract of Genista tinctoria L. herba(GT) or methylparaben(MP) on histopathological changes and 2 biomarkers of oxidative stress in rats subchronicly exposed to bisphenol A(BPA). Methods Adult female Wistar rats were orally exposed for 90 d to BPA(50 mg/kg), BPA+GT(35 mg isoflavones/kg) or BPA+MP(250 mg/kg). Plasma and tissue samples were taken from liver, kidney, thyroid, uterus, ovary, and mammary gland after 30, 60, and 90 d of exposure respectively. Lipid peroxidation and in vivo hydroxyl radical production were evaluated by histological analysis along with malondialdehyde and 2,3-dihydroxybenzoic acid detection. Results The severity of histopathological changes in liver and kidneys was lower after GT treatment than after BPA or BPA+MP treatment. A minimal thyroid receptor antagonist effect was only observed after BPA+MP treatment. The abnormal folliculogenesis increased in a time-dependent manner, and the number of corpus luteum decreased. No significant histological alterations were found in the uterus. The mammary gland displayed specific estrogen stimulation changes at all periods. Both MP and GT revealed antioxidant properties reducing lipid peroxidation and BPA-induced hydroxyl radical generation. Conclusion GT L. extract ameliorates the toxic effects of BPA and is proved to have antioxidant potential and antitoxic effect. MP has antioxidant properties, but has either no effect or exacerbates the BPA-induced histopathological changes. | Daniela-Saveta POPA Pompei BOLFA Bela KISS Laurian VLASE Ramona PLTINEAN Anca POP Cornel CTOI Gianina CRISAN Felicia LOGHIN | 2014 | Biomedical and Environmental Sciences2014，27，2： | 2 |
| 2 | Evaluation of adjuvant chemo-therapy irinotecan + 5 -fluorouracil + leucovorine in advanced colorectal cancer显示文摘 | Kulig J Pop iela T Richter P | 2007 | Acta Chir Belg2007，107，3： | 1 |
| 3 | Designing an MVC model for rapid Web application development显示文摘 | Pop D P Altar A | 2014 | Procedia Engineering2014，69，： | 1 |
| 4 | Comparative genomesequencing for discovery of novel polymorphisms in Bacillus anthracis 显示文摘 | Read TD Salzberg SL Pop M Shumway M Umayam L Jiang L Holtzapple E Busch JD Smith KL Schupp JM Solomon D Keim P Fraser CM | 2002 | Science2002，296，5575： | 1 |
| 5 | State-of-charge indica- tion in portable applications 显示文摘 | POP V BERGVELD H J NOTTEN P H L | 2005 | IEEE2005，，3： | 1 |
| 6 | Single cell analysis shows decreasing FoxP3 and TGF { beta } 1 coexpressing CD4 + CD25 + regulatory T cells during autoimmune diabetes显示文摘 | Wong C P Culton D A | 2005 | J Exp Med2005，201，8： | 1 |
| 7 | Maternal hypothyroxinaemia during early pregnancy and subsequent child development: a 3-year follow-up study显示文摘 | Pop V J Brouwers E P Vader H L | 2003 | Clin Endocrinol (Oxf)2003，59，3： | 1 |
| 8 | Performance estimation for embedded systems with data and control Dedendencies显示文摘 | Pop P Eles P Peng Z | 2000 | International Workshop on Hardware/Software Code sign2000，，8： | 1 |
| 9 | High variabilityin drug pharmacokinetic complicates determination of bioequivalence : experience with verapamil显示文摘 | Tsang YC Pop R Gordon P | 1996 | Pharm Res1996，13，8： | 1 |
| 10 | Effect of routine individual feedback over nine years ongeneral practitioners' requests for tests 显示文摘 | Winkens R A Pop P Grol R P | 1996 | BMJ1996，312，： | 1 |
| 11 | Design Optimization of TTEthernet-based Distributed Real-time Systems 显示文摘 | Selicean D T Pop P Steiner W | 2014 | Real-Time Systems2014，51，1： | 1 |
| 12 | State-of-charge indica- tion in portable applications 显示文摘 | POP V BERGVELD H J NOTTEN P H L | 2005 | IEEE2005，，3： | 1 |
| 13 | State-of-charge indication in portable applications显示文摘 | POP V BERGVELD H J NOTTEN P H L | 2005 | IEEE2005，3，： | 1 |
| 14 | Data exchange: getting to the core显示文摘 | FAGIN R KOLAITIS P G POPS L | 2005 | ACM TODS2005，30，1： | 1 |
| 15 | The growth of a thermal layer in a porous medium adjacent to a suddenly heated semi-infinite horizontal surfaces显示文摘 | Pop L Cheng P | 1983 | International Journal of Heat and Mass Transfer1983，26，11： | 1 |
| 16 | State-of-charge indication in portable applications 显示文摘 | POP V BERGVELD H J NOTTEN P H L | 2005 | IEEE2005，，3： | 1 |
| 17 | Timing analysis of the FlexRay communication protocol 显示文摘 | POP T POP P ELES P | 2008 | Real-Time Systems2008，39，1： | 1 |
| 18 | Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer’s disease显示文摘 | Adlard P A Perreau V M Pop V | 2005 | Neuroscience2005，25，17： | 1 |
| 19 | Optical character recognition in real environments using neural networks and K-nearest neighbor显示文摘 | MATEI O POP P C V?LEAN H | 2013 | Applied intelligence2013，39，4： | 1 |
| 20 | Design optimization of time and cost-constrained fault-tolerant embedded systems with checkpointing and replication显示文摘 | POP P IZOSIMOV V ELES P | 2009 | IEEE Transactions on Very Large Scale Integration Systems2009，17，3： | 1 |
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