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40篇 您的检索式:作者名="Ponticos"
    题名 作者 年代 出处 被引量
1Extracellular matrix synthesis in vascular disease:hypertension,and atherosclerosis显示文摘Extracellular matrix(ECM) within the vascular network provides both a structural and regulatory role.The ECM is a dynamic composite of multiple proteins that form structures connecting cells within the network.Blood vessels are distended by blood pressure and,therefore,require ECM components with elasticity yet with enough tensile strength to resist rupture.The ECM is involved in conducting mechanical signals to cells.Most importantly,ECM regulates cellular function through chemical signaling by controlling activation and bioavailability of the growth factors.Cells respond to ECM by remodeling their microenvironment which becomes dysregulated in vascular diseases such hypertension,restenosis and atherosclerosis.This review examines the cellular and ECM components of vessels,with specific emphasis on the regulation of collagen type I and implications in vascular disease.Markella Ponticos Barbara D.Smith 2014The Journal of Biomedical Research2014,28,1:12
2Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway显示文摘 Rajkumar V Ponticos M 2002FASEB J2002,16,14:1
3Pivotal role of connec- tive tissue growth factor in lung fibrosis显示文摘Ponticos M Holmes A M Shi-Wen X 2009Arthritis& Rheum2009,60,7:1
4A polymorphism in the CTGF promoter region associated with systemic sclerosis 显示文摘Fonseca C Lindahl GE Ponticos M 2007N Engl J Med 2007 202007,357,12:1
5Connective tissue remodeling:cross-talk between endothelins and matrixmetallop roteinases显示文摘Abraham D Ponticos M Nagase H 2005Curr Vasc Pharm Acol2005,3,4:1
6Pivotal role of connective growth factor in lung fibrosis:MAPK-dependent transcriptional activation of type Ⅰ collagen显示文摘Ponticos M Holmes AM Shi-wen X 0,,:1
7Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway显示文摘 RAJKUMAR V PONTICOS M 2002FASEB J2002,16,14:1
8Connective tissue growth factor(CCN2)in blood ves- sels显示文摘Ponticos M 2013Vascul Pharmacol2013,58,3:1
9A polymorphism in the CTGF promoter region associated with systemic sclerosis 显示文摘Fonseca C Lindahl GE Ponticos M 2007N gngl J Med2007,357,12:1
10Connective tissue remodeling:cross-talk between endothelins and matrix metalloproteinases显示文摘Abraham D Ponticos M Nagase H 2005Curr Vasc Pharmacol2005,3,4:1
11Pivotal role of connec- tive tissue growth factor in lung fibrosis: MAPK-dependent tran- scriptional activation of type I collagen显示文摘Ponticos M Holmes AM Shi-wen X 2009Arthritis Rheum2009,60,7:1
12Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle显示文摘Ponticos M Lu Q L Morgan J E 1998EMBO J1998,17,:1
13Connective tissue growth factor (CCN2) in blood vessels显示文摘Ponticos Markella 2013Vascul Pharmacol2013,58,3:1
14Pivotal role ofconnective tissue growth factor in lung fibrosis: MAPK-depend-ent transcriptional activation of type I collagen 显示文摘Ponticos M Holmes A M Shi-wen X 2009ArthritisRheum2009,60,7:1
15Increased endogenous angiogenic re-sponse and hypoxia-inducible factor-1αin human critical limb ischemia显示文摘Ho TK Rajkumar V Ponticos M 2006JVasc Surg2006,43,1:1
16Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle 显示文摘Markella Ponticos Qi Long Lu Jennifer E Morgan 1998The EMEBO Journal1998,17,:1
17Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-- dependent transcriptional activation of type I collagen 显示文摘Ponticos M Holmes A M Shi- wen X 2009Arthritis Rheum2009,60,7:1
18Dual regula- tion of the AMP-actlvated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle显示文摘PONTICOS M LU Q L MORGAN J E 1998EMBOJ1998,17,6:1
19A polymorphism in the CT-GF promoter region associated with systemic sclerosis显示文摘Fonseca C Lindahl GE Ponticos M 2007N Engl J Med2007,357,12:1
20Connective tissue remodeling: cross-talk between endothelins and matrix metalloproteinases显示文摘Abraham D Ponticos M Nagase H 2005Curr Vasc Pharmacol2005,3,4:1
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