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| 1 | 生物素——抗结核药物新研究方向(英文)显示文摘耐药菌的出现对全球公共卫生构成了巨大的挑战,结核分枝杆菌(TB)是结核病的病原菌,是临床上最重要的病原体之一。新抗生素的研发用以治疗耐药性结核病已成为临床及公共卫生管理亟待解决的重要问题。生物素(维生素B7)在结核杆菌的代谢途径如脂肪酸合成和三羧酸循环中发挥重要作用,通过生物素蛋白连接酶连接活性辅助因子而被激活。生物素蛋白连接酶及其相关生物合成通路是微生物合成生物素过程中必不可或缺的关键分子,因而有可能成为新的药物靶点。遗传研究表明,结核杆菌需要由菌体进行生物素的全程合成,因此,生物素合成酶在在结核杆菌代谢过程中起着至关重要的作用,引起了抗结核药物研究者的高度重视。本文论述了结核杆菌生物素合成通路,并重点分析了生物素合成过程中可能成为药物靶点的关键酶,旨在为结核病的治疗提供新思路,具有重要的临床意义。 | THOMPSON Andrew P STERNICKI Louise M WEGENER Kate L 陆伟 竺丽梅 BOOKER Grant W POLYAK Steven W 李燕 | 2016 | 江苏预防医学2016，27，3： | 4 |
| 2 | Gene Discovery Using the Serial Analysis of Gene Expression Technique: Implications for Cancer Research 显示文摘 | POLYAK K RIGGINS G L | 2001 | J Clin Oncol2001，19，11： | 1 |
| 3 | The method of projections for finding tile common point of convex sets 显示文摘 | GUBIN L G POLYAK B T RAIK E V | 1967 | Computational Mathematics and Mathematical Physics1967，7，6： | 1 |
| 4 | Past glacial and interglacial conditions in the Arctic Ocean and marginal seas-a review显示文摘 | DARBY D A POLYAK L BAUCH H A | 2006 | Progress in Oceanography2006，71，2006： | 1 |
| 5 | Provenance of Holocene sediment on the Chukchi-Alaskan margin based on combined diffuse spectral reflectance and quantitative X-Ray Diffraction analysis显示文摘 | Ortiz J D Polyak L Grebmeier J M | 2009 | Global and Planetary Change2009，68，12： | 1 |
| 6 | Molecular definition of breast tumor heterogeneity显示文摘 | Shipitsin M Lauren L Polyak K | 2007 | Cancer Cell2007，11，3： | 1 |
| 7 | A model for p53-induced apoptosis 显示文摘 | Polyak K Xia Y Zweier J L | 1997 | Nature1997，389，6648： | 1 |
| 8 | A model for p53-in- duced apoptosis显示文摘 | Polyak K Xia Y Zweier J L | 1997 | Nature1997，389，6648： | 1 |
| 9 | A model for p53-induced apoptosis显示文摘 | Polyak K Xia Y Zweier J L | 1997 | Nature1997，389，： | 1 |
| 10 | Contrasting gla- cial/ interglacial regimes in the western Arctic Ocean as ex- emplified by a sedimentary record from the Mendeleev Ridge 显示文摘 | Polyak L Curry W B Darby D A | 2004 | Palaeogeography Palaeoelimatology Palaeoecology2004，203，： | 1 |
| 11 | Quaternary sedimentation in the Arctic Ocean: recent advances and further challenges 显示文摘 | Polyak L Jakobsson M | 2011 | Oceanography2011，24，3： | 1 |
| 12 | Late Quaternary stratigraphy and sedimentation patterns in the western Arctic Ocean 显示文摘 | Polyak L Bischof J Ortiz J D | 2009 | Global and Planetary Change2009，68，12： | 1 |
| 13 | Late Quaternary stratig- raphy and sedimentation patterns in the western Arctic Ocean 显示文摘 | Polyak L Bischof J Ortiz J D | 2009 | Global and Planetary Change2009，68，： | 1 |
| 14 | Past glacial and intergla- cial conditions in the Arctic Ocean and marginal seas-A re- view显示文摘 | Darby D A Polyak L Bauch H A | 2006 | Progress in Oceanography2006，71，： | 1 |
| 15 | Contrasting glacial /interglacial regimes in the western Arctic Ocean as exempli fled by a sedimentary record from the Mendeleev Ridge显示文摘 | Polyak L Curry W B Darby D A | 2004 | Palaeogeography Palaeoclimatology Palaeoecology2004，203，12： | 1 |
| 16 | Breast tumor heterogeneity:causes and consequences显示文摘 | Polyak K Shipitsin M Campbell-Marrotta L | | 0，，1： | 1 |
| 17 | The role of currents and sea ice in both slowly deposited central Arctic and rapidly deposited Chukchi - Alaskan margin sediments显示文摘 | Darby D A Ortiz J D Polyak L | 2009 | Global Planetary Change2009，68，： | 1 |
| 18 | Molecular definition ofbreast tumor heterogeneity 显示文摘 | Shipitsin M Lauren L Polyak K | 2007 | Cancer Ce112007，11，3： | 1 |
| 19 | Molecular definition of breast tumor heterogeneity 显示文摘 | Shipitsin M Lauren L Polyak K | 2007 | Cancer Cell2007，11，3： | 1 |
| 20 | Late Quaternary stra- tigraphy and sedimentation patterns in the western Arctic Ocean 显示文摘 | Polyak L Bischof J Ortiz J D | 2009 | Global and Planetary Change2009，68，： | 1 |
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