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| 1 | 对乙酰氨基酚引起的急性肝衰竭:一项美国多中心前瞻性研究结果显示文摘Severe acetaminophen hepatotoxicity frequently leads to acute liver failure (ALF). We determined the incidence, risk factors, and outcomes of acetaminophen- induced ALF at 22 tertiary care centers in the United States. Detailed prospective data were gathered on 662 consecutive patients over a 6- year period fulfilling standard criteria for ALF (coagulopathy and encephalopathy), from which 275 (42% )were determined to result from acetaminophen liver injury. The annual percentage of acetaminophen-related ALF rose during the study from 28% in 1998 to 51% in 2003. Median dose ingested was 24 g (equivalent to 48 extra-strength tablets). Unintentional overdoses accounted for 131 (48% ) cases, intentional (suicide attempts) 122 (44% ), and 22 (8% ) were of unknown intent. In the unintentional group, 38% took two or more acetaminophen preparations simultaneously, and 63% used narcotic-containing compounds. Eighty-one percent of unintentional patients reported taking acetaminophen and/or other analgesics for acute or chronic pain syndromes. Overall, 178 subjects (65% ) survived, 74 (27% ) died without transplantation, and 23 subjects (8% ) underwent liver transplantation; 71% were alive at 3 weeks. Transplant free survival rate and rate of liver transplantation were similar between intentional and unintentional groups. In conclusion, acetaminophen hepatotoxicity far exceeds other causes of acute liver failure in the United States. Susceptible patients have concomitant depression, chronic pain, alcohol or narcotic use, and/or take several preparations simultaneously. Education of patients, physicians, and pharmacies to limit high-risk use settings is recommended. | Larson A.M. Polson J. Fontana R.J. 宋平 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，8： | 5 |
| 2 | Bayesian analysis of stochastic volatility models with fat-tails and correlated errors显示文摘 | Eric Jacquier Nicholas G. Polson Peter E. Rossi | 2003 | Journal of Econometrics2003，，1： | 2 |
| 3 | Bayesian Analysis of Stochastic Volatility Models显示文摘 | Eric Jacquier Nicholas G Polson Peter E Rossi | 2002 | Journal of Business & Economic Statistics2002，，1： | 2 |
| 4 | Interrelationship of inflammation and tooth mobility (trauma) in pathogenesis of periodontal disease 显示文摘 | Polson AM | 1980 | J Clin Periodontol1980，7，5： | 1 |
| 5 | The first X-ray structural evidence demonstrating thiolate coordination in an organocobalt B12 model complex:implications for methionine syntheses显示文摘 | Polson S M Hansen L Marzilli L G | 1997 | Inorg Chem1997，36，2： | 1 |
| 6 | Optimization of prmein precipitation based upon effectiveness of protein removal and ionization effect in liquid chromatography-tandem mase spectrometry显示文摘 | POLSON C SARKAR P INCLEDON B | 2003 | J Chromatogr B2003，785，： | 1 |
| 7 | AASLD position paper:the management of acute liver failure显示文摘 | Polson J Lee WM | 2005 | Hepatology2005，41，5： | 1 |
| 8 | Bayesian analysis of stochastic volatility models显示文摘 | Jacquier E Polson N G Rossi P E | | 0，，： | 1 |
| 9 | VIROME : a standard operating procedure for analysis of viral metagenome sequences 显示文摘 | Wommack KE Bhavsar J Polson SW | 2012 | Standards in Genomic Sciences2012，6，3： | 1 |
| 10 | The new institutionalism: organizational factors in political life显示文摘 | MARCH J G POLSON J P | 1984 | The American Political Science Review1984，，78： | 1 |
| 11 | Fire in the operating room: a case report and laboratory study显示文摘 | BARKER S J POLSON J S | 2001 | Anesth Analg2001，93，4： | 1 |
| 12 | Infection and the progression of encephlopathy in acute liver failure显示文摘 | Vaquero J Polson J Chung C | 2003 | Gastroenterlogy2003，125，： | 1 |
| 13 | AASLD position paper:the management of acute liver failure显示文摘 | Polson J Lee WM | 2005 | Hepatology2005，41，5： | 1 |
| 14 | Bayesian analysis of stochastic volatility models with fat-tails and correlated errors显示文摘 | Jacquier E Polson N G Rossi P E | | 0，，： | 1 |
| 15 | AASLD position paper:the management of acute liver failure显示文摘 | POLSON J LEE WM | 2005 | Hepatology2005，41，5： | 1 |
| 16 | The impact of jumps in volatility and returns显示文摘 | Eraker B Johannes M S Polson N G | | 0，，： | 1 |
| 17 | Managing sto- matitis in patients treated with mammalian target of rapamycin in- hibitors显示文摘 | PILOTTE AP HOHOS MB POLSON KM | 2011 | Clin J Oncol Nuts2011，15，5： | 1 |
| 18 | The Co-CH3 bond in imine/oxime B12 models influence of the orientation and donor properties of the trans ligand as assessed by FT-raman spectroscopy显示文摘 | Hirota S Polson S M Puckett Jr J M | 1996 | Inorg Chem1996，35，： | 1 |
| 19 | MCMC maximum likelihood for latent state models 显示文摘 | JACQUIERA E JOHANNESB M POLSON P | 2007 | Journal of Econometrics2007，137，2： | 1 |
| 20 | Pefiodontol diagnosis 显示文摘 | Polson AM | 1985 | Periodontol1985，56，： | 1 |
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