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您的检索式：作者名="Larson A.M."
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| 1 | 对乙酰氨基酚引起的急性肝衰竭:一项美国多中心前瞻性研究结果显示文摘Severe acetaminophen hepatotoxicity frequently leads to acute liver failure (ALF). We determined the incidence, risk factors, and outcomes of acetaminophen- induced ALF at 22 tertiary care centers in the United States. Detailed prospective data were gathered on 662 consecutive patients over a 6- year period fulfilling standard criteria for ALF (coagulopathy and encephalopathy), from which 275 (42% )were determined to result from acetaminophen liver injury. The annual percentage of acetaminophen-related ALF rose during the study from 28% in 1998 to 51% in 2003. Median dose ingested was 24 g (equivalent to 48 extra-strength tablets). Unintentional overdoses accounted for 131 (48% ) cases, intentional (suicide attempts) 122 (44% ), and 22 (8% ) were of unknown intent. In the unintentional group, 38% took two or more acetaminophen preparations simultaneously, and 63% used narcotic-containing compounds. Eighty-one percent of unintentional patients reported taking acetaminophen and/or other analgesics for acute or chronic pain syndromes. Overall, 178 subjects (65% ) survived, 74 (27% ) died without transplantation, and 23 subjects (8% ) underwent liver transplantation; 71% were alive at 3 weeks. Transplant free survival rate and rate of liver transplantation were similar between intentional and unintentional groups. In conclusion, acetaminophen hepatotoxicity far exceeds other causes of acute liver failure in the United States. Susceptible patients have concomitant depression, chronic pain, alcohol or narcotic use, and/or take several preparations simultaneously. Education of patients, physicians, and pharmacies to limit high-risk use settings is recommended. | Larson A.M. Polson J. Fontana R.J. 宋平 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，8： | 5 |
| 2 | Influence of the electronic structure on the ductile behavior of B2 CsCl-type AB intermetallics显示文摘 | K.A. Gschneidner Min Ji C.Z. Wang K.M. Ho A.M. Russell Ya. Mudryk A.T. Becker J.L. Larson | 2009 | Acta Materialia2009，，19： | 1 |
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