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| 1 | Non-steroidal anti-inflammatory drugs and statins in relation to colorectal cancer risk显示文摘AIM:To investigate the association between individual or combined use of non-steroidal anti-inflammatory drugs(NSAIDs) or statins and colorectal cancer risk.METHODS:In a population-based case-control study in women,we examined the association between NSAIDs and statin use and the risk of colorectal cancers.We further investigated whether the use of statins modifies the protective effect of NSAIDs.Female cases(n = 669) of colorectal cancer aged 50-74 years were identified from a statewide registry in Wisconsin during 1999-2001.Community control women(n = 1375) were randomly selected from lists of licensed drivers and Medicare beneficiaries.Medication use and risk factor information were gathered during a structured telephone interview.A multivariable logistic regression model was used to calculate odds ratio(OR) and 95% conf idence interval(CI) .RESULTS:Overall,NSAIDs users had a 30% reduction in risk of colorectal cancer(95% CI:0.56-0.88) .Statin use was not associated with colorectal cancer risk(OR = 1.17,95% CI:0.74-1.85) ,regardless of structural type(lipophilic or hydrophilic) ,duration of use,or recency.There was no evidence of an interaction between NSAIDs and statins and colorectal cancer risk(P-interaction = 0.28) .CONCLUSION:Although our results confirm the inverse association between NSAIDs use and colorectal cancer risk,they do not support a risk reduction in statin users,or an interaction effect of combined NSAIDs and statin use. | Mazyar Shadman Polly A Newcomb John M Hampton Karen J Wernli Amy Trentham-Dietz | 2009 | World Journal of Gastroenterology2009，15，19： | 5 |
| 2 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 3 | Cx26 deafness: mutation analysis and clinical variability显示文摘 | Murgia A Orzan E Polli R | 1999 | J Med Genet1999，36，： | 1 |
| 4 | Analysis of iliac crest bone grafting process measures 显示文摘 | Dhawan A Kukto TR Polly DW Jr | 2006 | Am J Orthop2006，35，7： | 1 |
| 5 | A Comparison of cabergoline and bromocriptine in the treatment of hyperprolactinemic amenorrhea显示文摘 | Webster J Piscitell G Polli A | 1994 | N Engl J Med1994，331，14： | 1 |
| 6 | Effects of the axial magnetic field component on the electron trajectory in the wiggler section显示文摘 | Migliano A C C de Polli A C J Stopa C R S | 1998 | IEEE Trans on Magnetics1998，34，： | 1 |
| 7 | Geometric morphometrics : recent applications to the study of evolution and development显示文摘 | Lawing A M Polly P D | 2010 | Journal of Zoology2010，280，1： | 1 |
| 8 | The role of efflux and uptake transporters in lapatinib (Tykerb, GW572016 ) disposition and drug interactions 显示文摘 | Polli J W Humplareys J E Harmon K A | 2008 | Drug Metab Dispos2008，36，4： | 1 |
| 9 | Vitamin E-TPGS increases absorption flux of an HIV protease inhibitor by enhancing its solubility and permeability显示文摘 | YU L BRIDGERS A POLLI J | 1999 | Pharm Res1999，16，12： | 1 |
| 10 | Transforaminal lumbar interbody fusion:clinical and radiographic results and complications in 100 consecutive patients显示文摘 | Potter B K Freedman B A Verwiebe E G Hall J M Polly D W Jr Kuklo T R | 2005 | J Spinal Disord Tech2005，18，： | 1 |
| 11 | All natural DR3-type vitamin D re-sponse elements show a similar functionality in vitro显示文摘 | TOELL A POLLY P CARLBERG C | 2000 | Biochem J2000，352，： | 1 |
| 12 | A comparison of cabergoline and bromocriptine in the treatment of hyperprolactinemic amenorrhea显示文摘 | Webster J Piscitelli G Polli A | 1994 | N Engl J Med1994，331，： | 1 |
| 13 | Analysis of iliac crest bone grafting process measures 显示文摘 | Dhawan A Kuklo TR Polly DW Jr | 2006 | Am Orthop (Belle Mead N J)2006，35，7： | 1 |
| 14 | Application of model-free kinetics to the study of thermal degradation of polycarbonate 显示文摘 | Polli H Pontes L A M Araujo A S | 2005 | Journal of Thermal Analysis and Calorimetry2005，79，2： | 1 |
| 15 | Rational use of in vitro P-glycoprotein assays in drug discovery显示文摘 | POLLI J W WRING S A HUMPHREYS J E | 2001 | J Pharmacol Exp Ther2001，299，1： | 1 |
| 16 | Vitamin E-TPGS increases absorption flux of an HIV protease inhibitor by enhancing its solubility and permeability 显示文摘 | Yu L Bridgers A Polli J | 1999 | Pharm Res1999，16，12： | 1 |
| 17 | Vitamin E-TPGS increas- es absorption flux of an HIV Protease inhibit or by enhanc- ing solubility and permeability显示文摘 | Yu L Bridgers A Polli J | 1999 | Pharm Res1999，16，12： | 1 |
| 18 | Rational use of in vitro P-glycoprotein assays in drug discovery显示文摘 | Polli J W Wring S A Humphreys J E | 2001 | J Pharmacol Exp Ther2001，299，62： | 1 |
| 19 | Rational use of in vitro P-glycoprotein assays in drug discovery显示文摘 | JOSEPH W POLLI STEPHEN A | 2001 | J Pharmacol Exp Ther2001，299，2： | 1 |
| 20 | Importance of roasted sulphide concentrates characterization in the hydrometallurgical extraction of zinc 显示文摘 | BALARINI J C POLLI L O MIRANDA T L S CASTRO R M Z SALUM A | 2008 | Minerals Engineering2008，21，1： | 1 |
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